Výsledky vyhledávání - "John Handshoe"

Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer

Autor: David R. Hout, Tracy Tucker, Rosetta Mazzola, Aly Karsan, Frank McMahon, Kasey Lawrence, David L. Saltman, Stephan W. Morris, Brock L. Schweitzer, Mary Lesperance, Rachel Skelton, John Handshoe

Publikováno v: Cancers; Volume 9; Issue 8; Pages: 99
Cancers
Cancers, Vol 9, Iss 8, p 99 (2017)

Patients with lung cancers harboring an activating anaplastic lymphoma kinase (ALK) rearrangement respond favorably to ALK inhibitor therapy. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are validated and widely used scree

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Detection of a TRAF1-ALK fusion in an anaplastic large cell lymphoma patient with chemotherapy and ALK inhibitor-resistant disease

Autor: David R. Hout, Brian R. Berry, Kasey Lawrence, Stephan W. Morris, David L. Saltman, John Handshoe, Rosetta Mazzola

Publikováno v: BMC Research Notes

Background The anaplastic lymphoma kinase (ALK) gene encodes a receptor tyrosine kinase, which was first identified as the fusion partner of the nucleophosmin (NPM1) gene in the recurrent t(2;5)(p23;q35) found in a subset of anaplastic large cell lym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6d4284335e4948795c9c5d79ff1b13
https://doi.org/10.1186/s13104-015-1277-7

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Novel qPCR screen for efficient and reliable identification of RET fusion-positive non-small cell lung cancer

Autor: Ryan Vincent, Brock L. Schweitzer, Rachel Skelton, Frank McMahon, Rebecca B Smith, David R. Hout, Stephan W. Morris, John Handshoe

Publikováno v: Journal of Clinical Oncology. 33:e22154-e22154

e22154 Background: The REarranged during Transfection (RET) protein is a cell surface receptor tyrosine kinase (RTK) critical for normal cell growth and differentiation; however, genetic alteration...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5adedab77159f32ebee333d53dfa7a25
https://doi.org/10.1200/jco.2015.33.15_suppl.e22154

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A prospective study to compare qPCR to IHC and FISH for the detection of anaplastic lymphoma kinase (ALK) fusions in FFPE specimens from NSCLC patients (PCRTALK)

Autor: Stephan W. Morris, David R. Hout, Aly Karsan, David L. Saltman, John Handshoe, Brock L. Schweitzer, Helena Daudt

Publikováno v: Journal of Clinical Oncology. 32:TPS11136-TPS11136

TPS11136 Background: Lung cancer is the most common cause of cancer-related deaths in North America. A number of pharmaceutical firms currently have therapies that target ALK-driven lung cancers in...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dde263409c861b9da54afb7a8d5449b
https://doi.org/10.1200/jco.2014.32.15_suppl.tps11136

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Routine Screening for Triple-Negative Adenocarcinoma (TNA) Lung Cancer Patients: A New Hope for a Poor-Prognosis Population

Autor: John Handshoe, Brock L. Schweitzer, Stephan W. Morris, David R. Hout, Kasey Lawrence, Rachel Skelton, Lindsay E. Chatfield

Publikováno v: American Journal of Clinical Pathology. 140:A149-A149

Lung cancer is the main cause of cancer mortality worldwide, 80% of which are non-small cell lung cancer (NSCLC) in type and >50% are adenocarcinoma in histology. Lung adenocarcinomas are mainly driven by three oncogenes, KRAS, EGFR, and ALK, leaving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae0f6a42fe2dc4872fa8064e772a0f6d
https://doi.org/10.1093/ajcp/140.suppl1.149

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Abstract 1930: The unknown piece of the pie: Molecular markers in triple-negative lung cancer

Autor: Rachel Skelton, Stephan W. Morris, Kasey Lawrence, Brock L. Schweitzer, Liquan Xue, Lindsay E. Chatfield, John Handshoe, David R. Hout

Publikováno v: Cancer Research. 73:1930-1930

Lung cancer is the main cause of cancer mortality worldwide. Approximately ∼80% of lung cancer cases are non-small cell lung cancer (NSCLC) in type and >50% of NSCLC are adenocarcinoma in histopathology. A shifting paradigm in the field of pulmonar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eff8cb8ab4e74e3fdc947ec7ca34af96
https://doi.org/10.1158/1538-7445.am2013-1930

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Abstract 2220: Insight ALK ScreenTM, a highly sensitive and specific RT-qPCR first-line screening assay for comprehensive detection of all oncogenic anaplastic lymphoma kinase (ALK) fusions: clinical validation

Autor: Kenneth Joel Bloom, Liquan Xue, Douglas T. Ross, Josh Nickols, John Handshoe, David R. Hout, Paul Choppa, Stephan W. Morris

Publikováno v: Cancer Research. 71:2220-2220

More than 15 different ALK fusions (e.g., CLTC-ALK, multiple EML4-ALK variants, KIF5B-ALK, NPM-ALK, RanBP2-ALK, TFG-ALK, TPM4-ALK, others) cause malignancies including NSCLC, NHL, and inflammatory myofibroblastic tumors. Preliminary studies suggest s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c412a8c427c5da8b036b5ee6747a548a
https://doi.org/10.1158/1538-7445.am2011-2220

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