Zobrazeno 1 - 10
of 24
pro vyhledávání: '"John H. Warner"'
Baseline multimodal information predicts future motor impairment in premanifest Huntington's disease
Autor:
Eduardo Castro, Pablo Polosecki, Irina Rish, Dorian Pustina, John H. Warner, Andrew Wood, Cristina Sampaio, Guillermo A. Cecchi
Publikováno v:
NeuroImage: Clinical, Vol 19, Iss , Pp 443-453 (2018)
In Huntington's disease (HD), accurate estimates of expected future motor impairments are key for clinical trials. Individual prognosis is only partially explained by genetics. However, studies so far have focused on predicting the time to clinical d
Externí odkaz:
https://doaj.org/article/909389c205d04a9b9f58108aa89c616f
Autor:
John H, Warner, Jeffrey D, Long, James A, Mills, Douglas R, Langbehn, Jennifer, Ware, Amrita, Mohan, Cristina, Sampaio
Publikováno v:
Journal of Huntington's Disease. 11:153-171
Background: Huntington’s disease (HD) is an autosomal dominant, neurological disease caused by an expanded CAG repeat near the N-terminus of the huntingtin (HTT) gene. A leading theory concerning the etiology of HD is that both onset and progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc137adb17245e18d3d3f604e3cad2a
https://doi.org/10.3233/jhd-210475
https://doi.org/10.3233/jhd-210475
Autor:
Maitrei Kohli, Dorian Pustina, John H Warner, Daniel C Alexander, Rachael I Scahill, Sarah J Tabrizi, Peter A Wijeratne
Publikováno v:
E: Imaging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76f49ebf35b1a883b1111e4d25a16d85
https://doi.org/10.1136/jnnp-2022-ehdn.89
https://doi.org/10.1136/jnnp-2022-ehdn.89
Publikováno v:
The Journal of Clinical Pharmacology. 60:1051-1060
Development of effective therapeutics that slow Huntington's disease progression is a research priority that requires an understanding of natural disease progression. We applied a population-modeling approach to describe the progression of 2 routinel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2e9fb1912564d3261ffb38e18ffdf7
https://doi.org/10.1002/jcph.1598
https://doi.org/10.1002/jcph.1598
Autor:
P. A. Wijeratne, John H. Warner, Dorian Pustina, Rachael I. Scahill, Daniel C. Alexander, Sarah J. Tabrizi, Maitrei Kohli
Publikováno v:
F: Clinical studies: case reports, observational studies and trials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50b7e780cedcc145abfa236afa10b768
https://doi.org/10.1136/jnnp-2021-ehdn.46
https://doi.org/10.1136/jnnp-2021-ehdn.46
Autor:
Cristina Sampaio, Amrita Mohan, Edward J. Wild, John H. Warner, Beth Ann Griffin, Claude Messan Setodji, Monica Busse, Marika Booth
Publikováno v:
Parkinsonism Relat Disord
Introduction\ud Despite being genetically inherited, it is unclear how non-genetic factors (e.g., substance use, employment) might contribute to the progression and severity of Huntington's disease (HD).\ud \ud Methods\ud We used propensity score (PS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4295b41f7e97924a82460a4fa9add383
Autor:
Monica Busse-Morris, Marika Booth, John H. Warner, Edward J. Wild, Beth Ann Griffin, Amrita Mohan, Claude Messan Setodji
Publikováno v:
Clinical studies.
Background Although Huntington’s disease (HD) is a genetically inherited disorder, it is not clear how non-genetic factors such as environment and behavior may contribute to progression. Aims We used a causal inference approach to run simulated pse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c65fd455e1d7a2983258413b25ff4c4c
https://doi.org/10.1136/jnnp-2018-ehdn.116
https://doi.org/10.1136/jnnp-2018-ehdn.116
Baseline multimodal information predicts future motor impairment in premanifest Huntington's disease
Autor:
Dorian Pustina, Eduardo Castro, Andrew Wood, John H. Warner, Guillermo A. Cecchi, Pablo Polosecki, Irina Rish, Cristina Sampaio
Publikováno v:
NeuroImage : Clinical
NeuroImage: Clinical, Vol 19, Iss, Pp 443-453 (2018)
NeuroImage: Clinical, Vol 19, Iss, Pp 443-453 (2018)
In Huntington's disease (HD), accurate estimates of expected future motor impairments are key for clinical trials. Individual prognosis is only partially explained by genetics. However, studies so far have focused on predicting the time to clinical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16e86ab995ce47cc9569ee4051efc5f
https://pubmed.ncbi.nlm.nih.gov/29984153
https://pubmed.ncbi.nlm.nih.gov/29984153
Autor:
Douglas R. Langbehn, Won Chan Lee, John H. Warner, Mitch DeKoven, Karen E. Anderson, J Giuliano, Victoria Divino
Publikováno v:
Journal of Huntington's Disease. 3:355-363
BACKGROUND Huntington's disease (HD) is a progressive neurodegenerative disease that spans distinct disease stages over 15-20 years. Various interventions are available which may allow patients to live outside of a nursing home for a longer time. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234d9d499ba795fcb93609bec7ac9c63
https://doi.org/10.3233/jhd-140124
https://doi.org/10.3233/jhd-140124
Autor:
John H. Warner, Allan J. Tobin, Blair R. Leavitt, Chris Becker, Howard Schulman, Raymund A.C. Roos, Sarah J. Tabrizi, Cristina Sampaio, Alexandra Durr, Beth Borowsky
Publikováno v:
Neurology, 80(21), 1934-1941
Objective: To evaluate plasma 8-hydroxy-deoxy-guanosine (8OHdG) levels as a potential biomarker of premanifest and early Huntington disease (HD). Methods: Personnel from 2 independent laboratories quantified 8OHdG in blinded longitudinal plasma sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f102e1688faa13abc8bceb860f1de39a
https://doi.org/10.1212/wnl.0b013e318293e1a1
https://doi.org/10.1212/wnl.0b013e318293e1a1