Zobrazeno 1 - 10
of 29
pro vyhledávání: '"John H. Tinsley"'
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 298:R713-R719
Hypertensive disorders of pregnancy are characterized by systemic and placental inflammation; however, treatment for these conditions has remained elusive. We tested whether administration of the anti-inflammatory cytokine interleukin-10 (IL-10) duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bbaca0429c0c9310428cd3fac65b635
https://doi.org/10.1152/ajpregu.00712.2009
https://doi.org/10.1152/ajpregu.00712.2009
Publikováno v:
American Journal of Hypertension. 22:1314-1319
BACKGROUND Preeclampsia (PE), a pregnancy-specific hypertensive syndrome, is one of the leading causes of premature births as well as fetal and maternal death. There is strong evidence that maternal immune system activation, of which Toll-like recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706d467eb4132a42481eaecf46c061c6
https://doi.org/10.1038/ajh.2009.185
https://doi.org/10.1038/ajh.2009.185
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L841-L847
Major cutaneous burns result in not only localized tissue damage but broad systemic inflammation causing organ system damage distal to the burn site. It is well recognized that many problems result from the release of inflammatory mediators that targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fb7785a4653635650e68c013973bd4
https://doi.org/10.1152/ajplung.00341.2003
https://doi.org/10.1152/ajplung.00341.2003
Autor:
Elena E. Ustinova, Mingzhang Guo, John H. Tinsley, Mack H. Wu, Primal de Lanerolle, Sarah Y. Yuan, Wenjuan Xu
Publikováno v:
Circulation Research. 90:1214-1221
Neutrophil-induced coronary microvascular leakage represents an important pathophysiological consequence of ischemic and inflammatory heart diseases. The precise mechanism by which neutrophils regulate endothelial barrier function remains to be estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026e2b6d3079410833627230b65ec54b
https://doi.org/10.1161/01.res.0000020402.73609.f1
https://doi.org/10.1161/01.res.0000020402.73609.f1
Publikováno v:
Molecular Genetics and Genomics. 264:433-440
Of the actin-related proteins, Arp1 is the most similar to conventional actin, and functions solely as a component of the multisubunit complex dynactin. Dynactin has been identified as an activator of the microtubule-associated motor cytoplasmic dyne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e81a8766fec441c6866af5b8ebe4dce
https://doi.org/10.1007/s004380000304
https://doi.org/10.1007/s004380000304
Publikováno v:
American Journal of Physiology-Cell Physiology. 279:C1285-C1289
The actomyosin complex is the major cytoskeletal component that controls cell contraction. In this study, we investigated the effects of actomyosin interaction on endothelial barrier function and gap formation. Activated myosin light chain kinase (ML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6c727c81b59804ff0ae297957571c8
https://doi.org/10.1152/ajpcell.2000.279.4.c1285
https://doi.org/10.1152/ajpcell.2000.279.4.c1285
Autor:
Mack H. Wu, Amy C. Taulman, Wenjuan Xu, John H. Tinsley, Elena E. Ustinova, Sarah Y. Yuan, Ferenc L. Korompai
Publikováno v:
Circulation Research. 87:412-417
Abstract —The functional disturbance of microvasculature is recognized as an initiating mechanism that underlies the development of various diabetic complications. Although a causal relationship between microvascular leakage and tissue damage has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4504151c250f3a770ccc5424aa1588
https://doi.org/10.1161/01.res.87.5.412
https://doi.org/10.1161/01.res.87.5.412
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 275:H1873-H1878
Although it is well recognized that microvascular endothelial cells play an important role in the local regulation of tissue perfusion and exchange processes, the precise effect of specific endothelial proteins on microvascular function remains to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0c7920dfdd4a246a1d7b56e076afac
https://doi.org/10.1152/ajpheart.1998.275.5.h1873
https://doi.org/10.1152/ajpheart.1998.275.5.h1873
Publikováno v:
Molecular Biology of the Cell. 7:731-742
Dynactin is a multisubunit complex that is required for cytoplasmic dynein, a minus-end-directed, microtubule-associated motor, to efficiently transport vesicles along microtubules in vitro. p150Glued, the largest subunit of dynactin, has been identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2dda61427c9b52ee6ed6c29b8eb383
https://doi.org/10.1091/mbc.7.5.731
https://doi.org/10.1091/mbc.7.5.731
Publikováno v:
Trends in Pharmacological Sciences. 25:64-66
Inflammatory lung diseases result in high rates of morbidity and mortality. Central to the pathogenesis of these diseases is disruption of endothelial barrier function. Activation of myosin light chain kinase (MLCK) is a key regulatory step in the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a3f16015139ebafae76c18547897c6
https://doi.org/10.1016/j.tips.2003.12.003
https://doi.org/10.1016/j.tips.2003.12.003