Zobrazeno 1 - 10
of 12
pro vyhledávání: '"John H. Tatlock"'
Autor:
Patrick J. Metz, Keith A. Ching, Tao Xie, Paulina Delgado Cuenca, Sherry Niessen, John H. Tatlock, Kristen Jensen-Pergakes, Brion W. Murray
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1935-1950.e8 (2020)
Summary: Alternative splicing is well understood to enhance proteome diversity as cells respond to stimuli. However, mechanistic understanding for how the spliceosome processes precursor messenger RNA (mRNA) transcripts to achieve template diversific
Externí odkaz:
https://doaj.org/article/c0c2219a2c9a4202a4e9067663eea1ff
Autor:
S. D. Hatch, Mark A. Muesing, Deborah A. Khalil, Nickolay Y. Chirgadze, Siegfried H. Reich, Vincent J. Kalish, Kenneth S. Su, Jeffrey A. Burgess, Krzysztof Appelt, Bruce A. Dressman, Penny P. Lubbehusen, Stephen W. Kaldor, Bhasker V. Shetty, Kristina M. Campanale, Jay F. Davies, David K. Clawson, John H. Tatlock, Maha B. Kosa, James E. Fritz, Amy K. Patick
Publikováno v:
Journal of Medicinal Chemistry. 40:3979-3985
Using a combination of iterative structure-based design and an analysis of oral pharmacokinetics and antiviral activity, AG1343 (Viracept, nelfinavir mesylate), a nonpeptidic inhibitor of HIV-1 protease, was identified. AG1343 is a potent enzyme inhi
Autor:
L. A. K. Pelletier, John H. Tatlock, Xinjun J. Hou, Richard E. Showalter, M. Angelica Linton, J. Ernest Villafranca, Charles R. Kissinger, Anna Tempczyk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1007-1012
The design, synthesis, and evaluation of small molecule, in vitro, inhibitors of human calcineurin is described. These ligands were derived from the known nonspecific phosphatase inhibitor endothall, and were modified to enhance binding and selectivi
Autor:
Susumo Katoh, J. Ernest Villafranca, Cristina T. Lewis, Michael Imbacuan, Richard E. Showalter, Babine Robert E, Littlefield Ethel S, Judy V. French, Hans E. Parge, Ted M. Bleckman, John H. Tatlock, L. A. K. Pelletier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:385-390
The design, synthesis, and structure activity relationships of a series of novel macrocyclic FKBP-12 ligands 1 are reported. The crystal structure of the complex between 7 and human FKBP-12 is reported and some SAR results are discussed based on this
Autor:
J. V. French, Richard E. Showalter, Hans E. Parge, Vincent J. Kalish, Daniel R. Knighton, John H. Tatlock, Christina T. Lewis, J. Ernest Villafranca
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2489-2494
The preparation and evaluation of potent small molecule inhibitors of FKBP-12 rotamase activity is described. These ligands contain many of the structural features of the FK506 pyranose ring region, yet are synthetically more accessible. The versatil
Autor:
Vincent J. Kalish, Krzysztof Appelt, Jay F. Davies, Mark J. Pino, B.‐W. Wu, Stephen W. Kaldor, Dzuy Nyugen, L. Musick, Bruce A. Dressman, John H. Tatlock, Reich Siegfried Heinz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:727-732
The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P 2 replacement groups. The 3-hydroxy-2-methyl ben
Autor:
L. Musick, B.‐W. Wu, Kalish, Varney, William H. Romines, Cindy L. Palmer, John H. Tatlock, Krzysztof Appelt, M R Reddy
Publikováno v:
Journal of Medicinal Chemistry. 37:2274-2284
The X-ray crystal-structure-based design, synthesis, computational evaluation, and activity of a novel class of HIV protease inhibitors are described. The initial lead compounds 2 and 3 were designed by modeling replacement groups for the C-terminal
Autor:
R. E. Showalter, Vincent J. Kalish, John H. Tatlock, Jesus Ernesto Villafranca, J. V. French, Daniel R. Knighton, Hans E. Parge, C. T. Lewis
Publikováno v:
ChemInform. 27
Autor:
S. Katoh, M. Imbacuan, John H. Tatlock, Littlefield Ethel S, R. E. Showalter, Babine Robert E, Hans E. Parge, C. T. Lewis, Jesus Ernesto Villafranca, T. M. Bleckman, J. V. French, L. A. K. Pelletier
Publikováno v:
ChemInform. 27
Autor:
C.R. Kissinger, L. A. K. Pelletier, John H. Tatlock, M. A. Linton, A. Tempczyk, Jesus Ernesto Villafranca, Xinjun Hou, R. E. Showalter
Publikováno v:
ChemInform. 28