Zobrazeno 1 - 10
of 10
pro vyhledávání: '"John H. Streiff"'
Publikováno v:
Journal of the Serbian Chemical Society, Vol 78, Iss 11, Pp 1655-1670 (2013)
The mechanism(s) of volatile anesthetics (VAs) are poorly under- stood. High-resolution NMR spectroscopy was used to determine the structure of the halothane-(Ca 2+ )4-calmodulin ((Ca 2+ )4- CaM) complex, and it was found that halothane molecules bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5662dd033a50df528fae07b60ffa9c2
https://doi.org/10.2298/jsc130523090j
https://doi.org/10.2298/jsc130523090j
Autor:
Keith A. Jones, Slobodan Macura, Elena Atanasova, John H. Streiff, Thomas Wesley Allen, Nenad Juranić, Alan R. Penheiter
Publikováno v:
Biophysical Journal. 91:3405-3414
Computational methods designed to predict and visualize ligand protein binding interactions were used to characterize volatile anesthetic (VA) binding sites and unoccupied pockets within the known structures of VAs bound to serum albumin, luciferase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11ca1e6969177c7d90499a2b44075d4
https://doi.org/10.1529/biophysj.106.082586
https://doi.org/10.1529/biophysj.106.082586
Autor:
David O. Warner, Nenad Juranić, Keith A. Jones, William J. Perkins, Slobodan Macura, John H. Streiff
Publikováno v:
Molecular Pharmacology. 66:929-935
The effects of anesthetics on cellular function may result from direct interactions between anesthetic molecules and proteins. These interactions have a low affinity and are difficult to characterize. To identify proteins that bind anesthetics, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d168c29860c32942806dd7578a1de5e
https://doi.org/10.1124/mol.66.4.929
https://doi.org/10.1124/mol.66.4.929
Autor:
John H. Streiff, Keith A. Jones
Publikováno v:
Journal of chemical information and modeling. 48(10)
The main objective of this work was to characterize VA binding sites in multiple anesthetic target proteins. A computational algorithm was used to quantify the solvent exclusion and aliphatic character of amphiphilic pockets in the structures of VA b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94668f0656bda77c3323e39df366b7f9
https://pubmed.ncbi.nlm.nih.gov/18808106
https://pubmed.ncbi.nlm.nih.gov/18808106
In apo and holoCaM, almost half of the hydrogen bonds (H-bonds) at the protein backbone expected from the corresponding NMR or X-ray structures were not detected by h3 J NC′ couplings. The paucity of the h3 J NC′ couplings was considered in terms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1444c8528021cea32bbdf5daff227ba9
https://europepmc.org/articles/PMC2206704/
https://europepmc.org/articles/PMC2206704/
Autor:
Sumedha G. Penheiter, Shuyan Wang, Alan R. Penheiter, David O. Warner, Joshua D. Spencer, Keith A. Jones, Fang Jin, John H. Streiff
Publikováno v:
Anesthesiology. 103(5)
Background Halothane is an effective bronchodilator and inhibits airway smooth muscle contraction in part by inhibiting intracellular signaling pathways activated by the M2 muscarinic receptor and its cognate inhibitory heterotrimeric guanosine-5'-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3348f3e1931dfb27bbe7f500256f8a5c
https://pubmed.ncbi.nlm.nih.gov/16249676
https://pubmed.ncbi.nlm.nih.gov/16249676
Autor:
John H, Streiff, Nenad O, Juranic, Slobodan I, Macura, David O, Warner, Keith A, Jones, William J, Perkins
Publikováno v:
Molecular pharmacology. 66(4)
The effects of anesthetics on cellular function may result from direct interactions between anesthetic molecules and proteins. These interactions have a low affinity and are difficult to characterize. To identify proteins that bind anesthetics, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::359918f49f0e8b273c966a0823af0cb9
https://pubmed.ncbi.nlm.nih.gov/15385643
https://pubmed.ncbi.nlm.nih.gov/15385643
Publikováno v:
Anesthesiology. 99(1)
Background Receptor-mediated increases in the force produced by airway smooth muscle are attenuated by anesthetics such as halothane. Guanosine 5'-triphosphate (GTP) binding protein alpha subunits (Galpha(i)) are known to participate in the regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b607ebcb335dc10b58eb464c1fad3e
https://pubmed.ncbi.nlm.nih.gov/12826849
https://pubmed.ncbi.nlm.nih.gov/12826849
Publikováno v:
Anesthesiology. 96:A91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c5d3111038187a76a6e41afbe565390
https://doi.org/10.1097/00000542-200209002-00091
https://doi.org/10.1097/00000542-200209002-00091
Autor:
Juranić, Nenad, Atanasova, Elena, Streiff, John H., Macura, Slobodan, Prendergast, Franklyn G.
Publikováno v:
Protein Science: A Publication of the Protein Society; 2007, Vol. 16 Issue 7, p1329-1337, 9p