Peritubular Macrophages Are Recruited to the Testis of Peripubertal Rats After Mono-(2-Ethylhexyl) Phthalate Exposure and Is Associated With Increases in the Numbers of Spermatogonia

Autor: Shavini N. Hewage, Ross Gillette, John H. Richburg, Jorine J L P Voss, Richa Tiwary

Publikováno v: Toxicol Sci

Peripubertal exposure of male rodents to the phthalate metabolite mono-(2-ethylhexyl) phthalate (MEHP) causes testicular inflammation, spermatocyte apoptosis, and disruption of the blood-testis barrier. The MEHP-induced inflammatory response in the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab3c94c01f6ed8d2a114c92d39bbb00
https://doi.org/10.1093/toxsci/kfab059

Characterization of the role of tumor necrosis factor apoptosis inducing ligand (TRAIL) in spermatogenesis through the evaluation of trail gene-deficient mice.

Autor: Yi-Chen Lin, John H Richburg

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93926 (2014)

TRAIL (TNFSF10/Apo2L) is a member of the tumor necrosis factor (TNF) superfamily of proteins and is expressed in human and rodent testis. Although the functional role of TRAIL in spermatogenesis is not known, TRAIL is recognized to induce apoptosis v

Externí odkaz: https://doaj.org/article/b15747edcb5e4a01afa506c01e7c1834

Mono-(2-ethylhexyl) phthalate-induced Sertoli cell injury stimulates the production of pro-inflammatory cytokines in Fischer 344 rats

Autor: Caitlin J. Murphy, Kristin R. Di Bona, Angela R Stermer, Jorine J L P Voss, Rashin Ghaffari, John H. Richburg

Publikováno v: Reproductive Toxicology. 69:150-158

Exposure of rodents to the Sertoli cell (SC) toxicant mono-(2-ethylhexyl) phthalate (MEHP) has been reported to trigger an infiltration of macrophages into the testis in an age- and species-dependent manner. Here we challenge the hypothesis that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735b481685c4251f11eadb1b5c87c2fd
https://doi.org/10.1016/j.reprotox.2017.02.013

Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice

Autor: Taiping Chen, John H. Richburg, Sharon Y.R. Dent, Raif S. Geha, Jean Louis Guénet, Caitlin J. Murphy, Carlos J. Perez, Janet Chou, Jean Jaubert, Tewfik Hamidi, Meichun Deng, Craig D. Platt, Qinghua Shi, Yue Lu, Héctor Gaitán-Peñas, Fernando Benavides, Kevin Lin, Jeesun Kim, Hui Lin Pan, Mark T. Bedford, Jianqiang Bao, Meng Hua Zhou, Huan Zhang, Yuying Huang, Raúl Estévez

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
JCI Insight
JCI Insight, American Society for Clinical Investigation, 2018, 3 (16), pp.e99767. ⟨10.1172/jci.insight.99767⟩
JCI Insight, 2018, 3 (16), pp.e99767. ⟨10.1172/jci.insight.99767⟩

International audience; Ion channel-controlled cell volume regulation is of fundamental significance to the physiological function of sperm. In addition to volume regulation, LRRC8A-dependent volume-regulated anion channel (VRAC) activity is involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb59899d04360969f84ccb27e341fc46
http://hdl.handle.net/2445/172306

The Sertoli Cell as a Target for Toxicants ☆

Autor: Caitlin J. Murphy, John H. Richburg, Jessica L. Myers

The Sertoli cell of the testicular seminiferous epithelium is a specialized cell that is responsible for regulating the continuous output of sperm cells throughout the life of the male. Knowledge of the multitude of processes that the Sertoli cells d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3feda126d38d38d08b6474582ceb915
https://doi.org/10.1016/b978-0-12-801238-3.02137-1