Zobrazeno 1 - 10
of 85
pro vyhledávání: '"John H. Peacock"'
Autor:
Neil G. Burnet, John H. Peacock, Francesca Carlomagno, Alison M. Dunning, Stephen P. Jackson, Jan Nyman, Ingela Turesson, Bruce A.J. Ponder
Publikováno v:
International Journal of Cancer. 85:845-849
In order to investigate the molecular basis of variation in response to ionising radiation (IR) in radiotherapy patients, we have studied the expression of several genes involved in DNA double-strand break repair pathways in fibroblast cell lines. Te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eda2ee1297ecddc41f52c13461bd28d
https://doi.org/10.1002/(sici)1097-0215(20000315)85:6<845::aid-ijc18>3.0.co
https://doi.org/10.1002/(sici)1097-0215(20000315)85:6<845::aid-ijc18>3.0.co
Publikováno v:
International Journal of Cancer. 79:606-613
Clinical radiotherapeutic doses are limited by the tolerance of normal tissues. Patients given a standard treatment exhibit a range of normal tissue reactions, and a better understanding of this individual variation might allow for individualisation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0511f2642425d32e7ac0c04046247405
https://doi.org/10.1002/(sici)1097-0215(19981218)79:6<606::aid-ijc9>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19981218)79:6<606::aid-ijc9>3.0.co
Autor:
John H. Peacock, M. Isabel Núñez, M. Villalobos, M. Teresa Valenzuela, M. Rosario Guerrero, Eva Siles, Escarlata López, J. Mariano Ruiz de Almodóvar, V. Pedraza, M. Rosario Del Moral
Publikováno v:
International Journal of Cancer. 76:354-361
The success of radiotherapy in eradicating tumours depends on the total radiation dose, but what limits this dose is the tolerance of the normal tissues within the treatment volume. Studies involving fibroblast survival have demonstrated the theoreti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a713ba2b55936893804fbf68fd673ec
https://doi.org/10.1002/(sici)1097-0215(19980504)76:3<354::aid-ijc12>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19980504)76:3<354::aid-ijc12>3.0.co
Publikováno v:
Radiotherapy and Oncology. 33:228-238
There is a wide variation in normal tissue reactions to radiotherapy and in many situations the severity of these reactions limits radiotherapy dose. Clinical fractionation studies carried out in Gothenburg have demonstrated that a large part of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d56d8e5eb15fb5fe63302118e58fbe3
https://doi.org/10.1016/0167-8140(94)90358-1
https://doi.org/10.1016/0167-8140(94)90358-1
Publikováno v:
Radiotherapy and Oncology. 28:219-227
At very low radiation dose rates, the proliferation of mammalian cells continues unaffected but as the dose rate is increased there comes a point at which it is interrupted. The dose rate at which this happens is often thought to be a significant fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8e3b758ff8b2c3079b412aa328d26c
https://doi.org/10.1016/0167-8140(93)90061-c
https://doi.org/10.1016/0167-8140(93)90061-c
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 26:837-843
The purpose of this study was to determine the relative sensitivity to cis-platinum, 4 MeV photons and 62.5 MeV (p[yields]Be[sup +]) neutrons in five human tumor cell lines, and their cis-platinum resistant variants. The degree of cross-resistance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0f9ea648a369f43da7e6e7c56e6029
https://doi.org/10.1016/0360-3016(93)90499-l
https://doi.org/10.1016/0360-3016(93)90499-l
Publikováno v:
Neurobiology of Aging. 13:697-704
In order to determine the effect of Alzheimer's disease on the relative distribution of soluble and membrane-bound molecular forms of acetylcholinesterase (AChE) in the brain, postmortem samples (delay interval less than 12 h) were obtained from pari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02553509f56b1fc20dade639a6ced20c
https://doi.org/10.1016/0197-4580(92)90092-c
https://doi.org/10.1016/0197-4580(92)90092-c
Publikováno v:
International Journal of Radiation Biology. 61:49-56
Cellular recovery was assessed in two sublines of L5178Y murine lymphoma cells of differing radiosensitivity (LY-S and LY-A4) using low dose-rate irradiation and split-dose experiments. No increase in cell survival was observed in the LY-S cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82572f5f05fdb55bfc24814c9a89a277
https://doi.org/10.1080/09553009214550611
https://doi.org/10.1080/09553009214550611
Publikováno v:
Neuroscience Letters. 118:197-200
In order to observe acetylcholinesterase (AChE) and its distribution into soluble and membrane-bound molecular forms in cholinergically denervated hippocampus, AChE was analyzed in the hippocampus of adult mice with and without bilateral fornix lesio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22ea0c4174831a74b739f93ea327c18
https://doi.org/10.1016/0304-3940(90)90625-j
https://doi.org/10.1016/0304-3940(90)90625-j
The Relationship of DNA Double-strand Break Induction to Radiosensitivity in Human Tumour Cell Lines
Publikováno v:
International Journal of Radiation Biology. 58:427-438
Recent data suggest that the differences in radiosensitivity between cell lines can be related to differences in dsb induction (Radford 1986a). In the light of this we have set out to assess the extent to which differences in radiation survival betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0201055990ad863366254297521f232c
https://doi.org/10.1080/09553009014551781
https://doi.org/10.1080/09553009014551781