Výsledky vyhledávání - "John H. Owen"

Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma

Autor: J. Chad Brenner, Mark E. Prince, Nicole L. Michmerhuizen, Kevin J. Kovatch, Hui Jiang, Jingyi Zhai, Molly E. Heft Neal, John H. Owen, Erin L. McKean

Publikováno v: J Neurol Surg B Skull Base

Objectives Targeted inhibitors of the PI3 kinase (PI3K) pathway have shown promising but incomplete antitumor activity in preclinical chordoma models. The aim of this study is to advance methodology for a high-throughput drug screen using chordoma mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fac1ec1b48017a31e00c52d7fd6b1a7
https://pubmed.ncbi.nlm.nih.gov/35155075

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Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines

Autor: Thomas W. Glover, John H. Owen, Bin Tean Teh, Ruud H. Brakenhoff, Christine M. Goudsmit, Carol R. Bradford, Susanne M. Gollin, Thomas K. Hoffmann, Robert L. Ferris, Heather M. Walline, Thomas E. Carey, Henning Bier, Douglas B. Chepeha, Mark E. Prince, Erin L. McKean, Martin P. Graham, Jonathan B. McHugh, Alice Tang, Steven B. Chinn

Publikováno v: Head & Neck. 39:840-852

Background Human papillomavirus (HPV)-positive oropharyngeal cancer is generally associated with excellent response to therapy, but some HPV-positive tumors progress despite aggressive therapy. The purpose of this study was to evaluate viral oncogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0569a074f3cbe775801850c23a9392ac
https://doi.org/10.1002/hed.24729

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Evaluation of the immunogenicity of ALDHhigh human head and neck squamous cell carcinoma cancer stem cells in vitro

Autor: Mark E. Prince, Qiao Li, Max S. Wicha, Alfred E. Chang, Lin Lu, Jeffrey S. Moyer, Shiang Huang, Huimin Tao, Martin Etigen, Fang Zheng, Gregory T. Wolf, Jian-Chuan Xia, Xiubao Ren, John H. Owen, Li Zhou

Publikováno v: Oral Oncology. 59:30-42

Summary Objectives To establish the concept that the antigenicity/immunogenicity of ALDH high human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH low non-CSCs. Methods We generated CSC-loaded dend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea9b2f220e979c7ebf36ade26902d81
https://doi.org/10.1016/j.oraloncology.2016.05.013

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STAT3 Inhibition as a Therapeutic Strategy for Chordoma

Autor: Meijuan Lin, Erin L. McKean, Anthony C. Wang, Thomas E. Carey, Xiaobing He, Waleed M. Abuzeid, Mark E. Prince, Shawn L. Hervey-Jumper, David B. Altshuler, Stephen E. Sullivan, Mikel Gurrea, Richard F. Keep, Xing Fan, John H. Owen

Publikováno v: Journal of Neurological Surgery Part B: Skull Base. 77:510-520

Objective Signal transducer and activator of transcription (STAT) proteins regulate key cellular fate decisions including proliferation and apoptosis. STAT3 overexpression induces tumor growth in multiple neoplasms. STAT3 is constitutively activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c630468766a7c7dcdbf25be4613f64
https://doi.org/10.1055/s-0036-1584198

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Abstract B32: Impact of cancer-associated fibroblasts on head and neck cancer stem cells

Autor: John H. Owen, Matthew E. Spector, Mark E. Prince, Steven B. Chinn, Thomas E. Carey, Molly E. Heft Neal

Publikováno v: Clinical Cancer Research. 26:B32-B32

Background: The tumor microenvironment (TME) is made up of epithelial cancer cells and mesenchymal stromal cells including tumor-infiltrating lymphocytes, cancer-associated fibroblasts (CAFs) and endothelial cells. Within the cancer cell population a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb91909ea7c78f122fdc3affee49fd46
https://doi.org/10.1158/1557-3265.aacrahns19-b32

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Novel method of cell line establishment utilizing fluorescence-activated cell sorting resulting in 6 new head and neck squamous cell carcinoma lines

Autor: Owen F. Darr, Douglas B. Chepeha, Carol R. Bradford, Thomas E. Carey, John H. Owen, Mark E. Prince, Steven B. Chinn, Gregory T. Wolf, Martin P. Graham

Publikováno v: Head & Neck. 38:E459-E467

Background The purpose of this study was to present the establishment of new cell lines, which is important to cancer research. Methods Six new head and neck squamous cell carcinoma cell lines were established using a novel fluorescence-activated cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a4773f092f4ad72fb81b27174cd30da
https://doi.org/10.1002/hed.24019

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UM-Chor1: establishment and characterization of the first validated clival chordoma cell line

Autor: Richard F. Keep, Xing Fan, Mark E. Prince, Erin L. McKean, Christine M. Komarck, John H. Owen, Waleed M. Abuzeid, Stephen E. Sullivan, Anthony C. Wang

Publikováno v: Journal of neurosurgery, vol 128, iss 3

OBJECTIVEChordomas are rare malignant tumors thought to arise from remnants of the notochord. They can be located anywhere along the axial skeleton but are most commonly found in the clival and sacrococcygeal regions, where the notochord regresses du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852782cc8bef39954ca55cc388ce7d38
https://pubmed.ncbi.nlm.nih.gov/28524794

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Evaluation of CD44 Variant Expression in Oral, Head and Neck Squamous Cell Carcinomas Using a Triple Approach and its Clinical Significance

Autor: Vasu Divi, Maria Athanassiou-Papaefthymiou, Omar Shkeir, Petros Papagerakis, Mark E. Prince, Jonathan B. McHugh, G.T. Wolf, Silvana Papagerakis, Margarite D. Matossian, Carol R. Bradford, John H. Owen, Michael Czerwinski, Thomas E. Carey, Doohak Kim

Publikováno v: Scopus-Elsevier

Cancer stem cells possess the qualities of self-renewal, tumorigenesis and the ability to recapitulate a heterogeneous tumor. Our group was the first to isolate head and neck squamous cell carcinoma (HNSCC) stem cells using the cell surface marker CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2600550f120204cb245776b056b1ade5
https://doi.org/10.1177/039463201402700304

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Cancer stem cells: Mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma

Autor: Matthew E. Spector, Thomas E. Carey, Mark E. Prince, Carol R. Bradford, John H. Owen, Steven B. Chinn, Owen A.F. Darr, Jonathan B. McHugh, Silvana Papagerakis, Douglas B. Chepeha, Emily Bellile

Publikováno v: Head & Neck. 37:317-326

Background Cancer stem cells (CSC) represent a subpopulation of cells responsible for tumor growth. Their role in head and neck squamous cell carcinoma (HNSCC) tumorigenesis and metastasis remains uncertain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c655315f9ddb4f8937ff4f76243947b6
https://doi.org/10.1002/hed.23600

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Head and Neck Cancer Stem Cells: The Effect of HPV—An In Vitro and Mouse Study

Autor: John H. Owen, Silvana Papagerakis, Carol R. Bradford, Alice Tang, Thomas E. Carey, Jung Je Park, Mark E. Prince, Samantha J. Hauff

Publikováno v: Otolaryngology–Head and Neck Surgery. 149:252-260

To determine if the behavior of cancer stem cells (CSCs) is affected by human papillomavirus (HPV) status.An in vitro and in vivo analysis of HPV and CSCs.University laboratory.We isolated CSCs from HPV-positive and HPV-negative cell lines. Two HPV-n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9edb6db822e60b0d60ff9f88a26838
https://doi.org/10.1177/0194599813486599

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