Zobrazeno 1 - 10
of 88
pro vyhledávání: '"John H. Owen"'
Autor:
J. Chad Brenner, Mark E. Prince, Nicole L. Michmerhuizen, Kevin J. Kovatch, Hui Jiang, Jingyi Zhai, Molly E. Heft Neal, John H. Owen, Erin L. McKean
Publikováno v:
J Neurol Surg B Skull Base
Objectives Targeted inhibitors of the PI3 kinase (PI3K) pathway have shown promising but incomplete antitumor activity in preclinical chordoma models. The aim of this study is to advance methodology for a high-throughput drug screen using chordoma mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fac1ec1b48017a31e00c52d7fd6b1a7
https://pubmed.ncbi.nlm.nih.gov/35155075
https://pubmed.ncbi.nlm.nih.gov/35155075
Autor:
Thomas W. Glover, John H. Owen, Bin Tean Teh, Ruud H. Brakenhoff, Christine M. Goudsmit, Carol R. Bradford, Susanne M. Gollin, Thomas K. Hoffmann, Robert L. Ferris, Heather M. Walline, Thomas E. Carey, Henning Bier, Douglas B. Chepeha, Mark E. Prince, Erin L. McKean, Martin P. Graham, Jonathan B. McHugh, Alice Tang, Steven B. Chinn
Publikováno v:
Head & Neck. 39:840-852
Background Human papillomavirus (HPV)-positive oropharyngeal cancer is generally associated with excellent response to therapy, but some HPV-positive tumors progress despite aggressive therapy. The purpose of this study was to evaluate viral oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0569a074f3cbe775801850c23a9392ac
https://doi.org/10.1002/hed.24729
https://doi.org/10.1002/hed.24729
Autor:
Xin Chen, Qiao Li, Fu Dai, Robert E. Hollingsworth, Yi Wang, Mark E. Prince, Yangyi Bao, Jian Chuan Xia, Yangyang Hu, Alfred E. Chang, Lin Lu, Yang Xia, John H. Owen, Max S. Wicha, Jeffrey S. Moyer, Elaine M. Hurt, Joel Whitfield, Shiang Huang
Publikováno v:
Cancer Research. 76:4661-4672
Dendritic cell (DC)-based vaccine strategies aimed at targeting cancer stem–like cells (CSC) may be most efficacious if deployed in the adjuvant setting. In this study, we offer preclinical evidence that this is the case for a CSC-DC vaccine as tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1bade4a91e360decd048fd424d1ed5
https://doi.org/10.1158/0008-5472.can-15-2664
https://doi.org/10.1158/0008-5472.can-15-2664
Autor:
Mark E. Prince, Qiao Li, Max S. Wicha, Alfred E. Chang, Lin Lu, Jeffrey S. Moyer, Shiang Huang, Huimin Tao, Martin Etigen, Fang Zheng, Gregory T. Wolf, Jian-Chuan Xia, Xiubao Ren, John H. Owen, Li Zhou
Publikováno v:
Oral Oncology. 59:30-42
Summary Objectives To establish the concept that the antigenicity/immunogenicity of ALDH high human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH low non-CSCs. Methods We generated CSC-loaded dend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea9b2f220e979c7ebf36ade26902d81
https://doi.org/10.1016/j.oraloncology.2016.05.013
https://doi.org/10.1016/j.oraloncology.2016.05.013
Autor:
Meijuan Lin, Erin L. McKean, Anthony C. Wang, Thomas E. Carey, Xiaobing He, Waleed M. Abuzeid, Mark E. Prince, Shawn L. Hervey-Jumper, David B. Altshuler, Stephen E. Sullivan, Mikel Gurrea, Richard F. Keep, Xing Fan, John H. Owen
Publikováno v:
Journal of Neurological Surgery Part B: Skull Base. 77:510-520
Objective Signal transducer and activator of transcription (STAT) proteins regulate key cellular fate decisions including proliferation and apoptosis. STAT3 overexpression induces tumor growth in multiple neoplasms. STAT3 is constitutively activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c630468766a7c7dcdbf25be4613f64
https://doi.org/10.1055/s-0036-1584198
https://doi.org/10.1055/s-0036-1584198
Autor:
John H. Owen, Matthew E. Spector, Mark E. Prince, Steven B. Chinn, Thomas E. Carey, Molly E. Heft Neal
Publikováno v:
Clinical Cancer Research. 26:B32-B32
Background: The tumor microenvironment (TME) is made up of epithelial cancer cells and mesenchymal stromal cells including tumor-infiltrating lymphocytes, cancer-associated fibroblasts (CAFs) and endothelial cells. Within the cancer cell population a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb91909ea7c78f122fdc3affee49fd46
https://doi.org/10.1158/1557-3265.aacrahns19-b32
https://doi.org/10.1158/1557-3265.aacrahns19-b32
Autor:
Owen F. Darr, Douglas B. Chepeha, Carol R. Bradford, Thomas E. Carey, John H. Owen, Mark E. Prince, Steven B. Chinn, Gregory T. Wolf, Martin P. Graham
Publikováno v:
Head & Neck. 38:E459-E467
Background The purpose of this study was to present the establishment of new cell lines, which is important to cancer research. Methods Six new head and neck squamous cell carcinoma cell lines were established using a novel fluorescence-activated cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a4773f092f4ad72fb81b27174cd30da
https://doi.org/10.1002/hed.24019
https://doi.org/10.1002/hed.24019
Autor:
Richard F. Keep, Xing Fan, Mark E. Prince, Erin L. McKean, Christine M. Komarck, John H. Owen, Waleed M. Abuzeid, Stephen E. Sullivan, Anthony C. Wang
Publikováno v:
Journal of neurosurgery, vol 128, iss 3
OBJECTIVEChordomas are rare malignant tumors thought to arise from remnants of the notochord. They can be located anywhere along the axial skeleton but are most commonly found in the clival and sacrococcygeal regions, where the notochord regresses du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852782cc8bef39954ca55cc388ce7d38
https://pubmed.ncbi.nlm.nih.gov/28524794
https://pubmed.ncbi.nlm.nih.gov/28524794
Autor:
Vasu Divi, Maria Athanassiou-Papaefthymiou, Omar Shkeir, Petros Papagerakis, Mark E. Prince, Jonathan B. McHugh, G.T. Wolf, Silvana Papagerakis, Margarite D. Matossian, Carol R. Bradford, John H. Owen, Michael Czerwinski, Thomas E. Carey, Doohak Kim
Publikováno v:
Scopus-Elsevier
Cancer stem cells possess the qualities of self-renewal, tumorigenesis and the ability to recapitulate a heterogeneous tumor. Our group was the first to isolate head and neck squamous cell carcinoma (HNSCC) stem cells using the cell surface marker CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2600550f120204cb245776b056b1ade5
https://doi.org/10.1177/039463201402700304
https://doi.org/10.1177/039463201402700304
Autor:
Matthew E. Spector, Thomas E. Carey, Mark E. Prince, Carol R. Bradford, John H. Owen, Steven B. Chinn, Owen A.F. Darr, Jonathan B. McHugh, Silvana Papagerakis, Douglas B. Chepeha, Emily Bellile
Publikováno v:
Head & Neck. 37:317-326
Background Cancer stem cells (CSC) represent a subpopulation of cells responsible for tumor growth. Their role in head and neck squamous cell carcinoma (HNSCC) tumorigenesis and metastasis remains uncertain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c655315f9ddb4f8937ff4f76243947b6
https://doi.org/10.1002/hed.23600
https://doi.org/10.1002/hed.23600