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of 87
pro vyhledávání: '"John H. Karam"'
Autor:
John H. Karam
Publikováno v:
Endocrinology and Metabolism Clinics of North America. 21:329-350
Non-insulin-dependent diabetes (NIDDM) has long been recognized as being associated with a cluster of disorders including obesity, hypertension, dyslipidemia, and atherosclerotic heart disease. It was only recently, however, that Reaven, DeFronzo, an
Autor:
Alan C. Moses, John H. Karam, Martha S. Nolte, C. Taboga, Jeffrey S. Flier, J. Longenecker, Elizabeth Salamon
Publikováno v:
Hormone and Metabolic Research. 22:170-174
Nasally administered (IN) insulin has been advocated as a potentially useful alternative to subcutaneously administered regular insulin because of its more rapid onset and time to peak action and its shorter duration of action. This study further def
Publikováno v:
Ciba Foundation Symposium 130-Molecular Approaches to Human Polygenic Disease
Diabetes mellitus is a clinically heterogeneous disorder which is characterized by hyperglycaemia due to an absolute or relative deficiency of insulin. Both genetic and non-genetic factors contribute to its development and, as such, it represents a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409509826a03192ddafbbe935e6f4392
https://doi.org/10.1002/9780470513507.ch10
https://doi.org/10.1002/9780470513507.ch10
Autor:
John H. Karam
Publikováno v:
Endocrinology and Metabolism Clinics of North America. 21:xi-xiii
Autor:
Leslie Z. Benet, Chui Y. Liu, Anita M. Goodman, Nancy C. Sambol, Janie Chiang, John H. Karam, Emil T. Lin, Michael O'Conner
Publikováno v:
Journal of clinical pharmacology. 36(11)
This study was conducted to assess the effect of noninsulin-dependent diabetes mellitus (NIDDM) and gender on the pharmacokinetics of metformin and to investigate whether or not metformin exhibits dose-dependent pharmacokinetics. The pharmacodynamic
Autor:
Tracy S. Seo, K. Yasuda, John H. Karam, Graeme I. Bell, John B. Buse, Tracy P. Lay, Susumu Seino, Jeffrey E. Pessin, Ann Louise Olson
Publikováno v:
Diabetes. 41(11)
Four overlapping DNA fragments spanning 32 kb containing the human GLUT4 facilitative glucose-transporter gene were isolated and characterized. The sequence of the GLUT4 gene (approximately 6.3 kb) and 2.0 kb of the promoter region was determined. Th
Publikováno v:
DICP : the annals of pharmacotherapy. 24(11)
In 1985, investigators reported that four months of pentoxifylline therapy resulted in a significant decrease in proteinuria (46 percent reduction) and plasma fibrinogen concentrations (18 percent reduction) in patients with diabetes. Our study evalu
Autor:
John H. Karam
Publikováno v:
Diabetes. 45:1282-1283
Publikováno v:
Diabetes. 34:433-439
A polymorphic region 5' to the human insulin gene has been associated with diabetes in earlier studies. This polymorphic region is composed of tandem repeats that fall into 3 general size classes, designated class 1 (600 base pairs), class 2 (1300 ba
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 40:1121-1124
The effects of somatostatin on tolbutamide-stimulated insulin release were studied in 4 patients with insulin-producing tumors of the pancreas and in 6 normal subjects. In contrast to its effective inhibition of insulin release in normal subjects, so