Multiscale biphasic modelling of peritumoural collagen microstructure: The effect of tumour growth on permeability and fluid flow.

Autor: Peter A Wijeratne, John H Hipwell, David J Hawkes, Triantafyllos Stylianopoulos, Vasileios Vavourakis

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184511 (2017)

We present an in-silico model of avascular poroelastic tumour growth coupled with a multiscale biphasic description of the tumour-host environment. The model is specified to in-vitro data, facilitating biophysically realistic simulations of tumour sp

Externí odkaz: https://doaj.org/article/8926bc3ca3e5410fa3f2a3cb70894d5c

Circulating Growth and Sex Hormone Levels and Breast Tissue Composition in Young Nulliparous Women

Autor: John H. Hipwell, Jeffrey M P Holly, Rachel Denholm, Elizabeth Folkerd, Isabel dos-Santos-Silva, Bianca De Stavola, Simon J. Doran, Martin O. Leach, David J. Hawkes, Mitch Dowsett

Publikováno v: Denholm, R, De Stavola, B L, Hipwell, J H, Doran, S J, Holly, J M P, Folkerd, E, Dowsett, M, Leach, M O, Hawkes, D J & Dos-Santos-Silva, I 2018, ' Circulating growth and sex hormone levels and breast tissue composition in young nulliparous women ', Cancer Epidemiology, Biomarkers and Prevention, vol. 27, no. 12, pp. 1500-1508 . https://doi.org/10.1158/1055-9965.EPI-18-0036

Background: Endogenous hormones are associated with breast cancer risk, but little is known about their role on breast tissue composition, a strong risk predictor. This study aims to investigate the relationship between growth and sex hormone levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a4f5b43495180ff8c803b6941321f9
https://doi.org/10.1158/1055-9965.epi-18-0036

Symmetric Biomechanically Guided Prone-to-Supine Breast Image Registration

Autor: Thomas Buelow, David J. Hawkes, Sven Kabus, Thomy Mertzanidou, Björn Eiben, Vasileios Vavourakis, Cristian Lorenz, Norman R. Williams, Mohammed Keshtgar, John H. Hipwell, Sara Reis

Publikováno v: Annals of Biomedical Engineering

Prone-to-supine breast image registration has potential application in the fields of surgical and radiotherapy planning, image guided interventions, and multi-modal cancer diagnosis, staging, and therapy response prediction. However, breast image reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebec9ea11015ba94fb9e900457557c43
http://europepmc.org/articles/PMC4690842

Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide

Autor: Beata Peplonska, Farhana Fadzli, Ana Pereira, Caroline Dickens, Eunjung Lee, Jisun Kim, Joachim Schüz, John L. Hopper, Sudhir Vinayak, Soo Hwang Teo, Jennifer Stone, Marina Pollán, Rulla M. Tamimi, Shivaani Mariapun, Ruy Lopez-Ridaura, Celine M. Vachon, Linda Linton, Mikael Hartman, Carla H. van Gils, Rose Ndumia, Mehri Sirous, Norman F. Boyd, Vahit Ozmen, Mustafa Erkin Aribal, Anya Burton, Giske Ursin, María Luisa Garmendia, Jong Won Lee, Gertraud Maskarinec, Reza Sirous, Chisato Nagata, Kee Seng Chia, Megan S. Rice, John H. Hipwell, Valerie McCormack, Sarah Vinnicombe, Martin Lajous, Hui Miao, Rasha Kamal, Ava Kwong, Anath Arzee Flugelman, Sue Moss, Agnieszka Bukowska, Graham G. Giles, Steve Allen, Christopher G. Scott, Anna M. Chiarelli, Samera Azeem Qureshi, Huiyan Ma, Johanna O. P. Wanders, Kimberly A. Bertrand, Isabel dos-Santos-Silva, Beatriz Pérez-Gómez, Dorria Salem

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Medicine, Vol 14, Iss 6, p e1002335 (2017)
PLoS Medicine, 14(6). Public Library of Science
PLoS Medicine

Background Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known. Methods an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e1cb4e0b96a6eaca8f83a2f3e7d927

Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review

Autor: Amanda Eng, Mona Jeffreys, John H. Hipwell, Martin O. Leach, Isabel dos Santos Silva, David J. Hawkes, Rachel Denholm, Bianca De Stavola, Marta Cecilia Busana, Simon J. Doran

Publikováno v: Breast Cancer Research : BCR
Denholm, R, De Stavola, B, Hipwell, J H, Doran, S J, Busana, M C, Eng, A, Jeffreys, M, Leach, M O, Hawkes, D & dos Santos Silva, I 2016, ' Pre-natal exposures and breast tissue composition : Findings from a British pre-birth cohort of young women and a systematic review ', Breast Cancer Research, vol. 18, 102 . https://doi.org/10.1186/s13058-016-0751-z

Background Breast density, the amount of fibroglandular tissue in the adult breast for a women’s age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, be influenced by events e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2165914fe5fc972b8fb847415c55722a
https://researchonline.lshtm.ac.uk/id/eprint/2965168/1/art%3A10.1186%2Fs13058-016-0751-z.pdf