Zobrazeno 1 - 10
of 22
pro vyhledávání: '"John H. Carra"'
Autor:
Patricia M. Legler, Stephen F. Little, Jeffrey Senft, Rowena Schokman, John H. Carra, Jaimee R. Compton, Donald Chabot, Steven Tobery, David P. Fetterer, Justin B. Siegel, David Baker, Arthur M. Friedlander
Publikováno v:
Science Translational Medicine. 13
Anthrax is considered one of the most dangerous bioweapon agents, and concern about multidrug-resistant strains has led to the development of alternative therapeutic approaches that target the antiphagocytic capsule, an essential virulence determinan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c556986661e55ea46c191088a9dd4ccf
https://doi.org/10.1126/scitranslmed.abh1682
https://doi.org/10.1126/scitranslmed.abh1682
Cross-Protection Conferred by Filovirus Virus-Like Particles Containing Trimeric Hybrid Glycoprotein
Autor:
John H. Carra, Amy C. Shurtleff, Camenzind G. Robinson, Jesse T. Steffens, Rowena D Schokman, Jay W. Hooper, Jay Wells, Sean A. Van Tongeren, Steven A. Kwilas, Christopher L. Cooper, Karen A. Martins, Sina Bavari, Kathleen A. Kuehl
Publikováno v:
Viral Immunology. 28:62-70
Filoviruses are causative agents of hemorrhagic fever, and to date no effective vaccine or therapeutic has been approved to combat infection. Filovirus glycoprotein (GP) is the critical immunogenic component of filovirus vaccines, eliciting high leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30400a6af7320f0a0ad34d6e9c5b2809
https://doi.org/10.1089/vim.2014.0071
https://doi.org/10.1089/vim.2014.0071
Autor:
Peixian Liu, John H. Carra, Jeffrey L. Senft, David Baker, Sean J. Wu, Cindy T. Wu, Rowena D Schokman, Arthur M. Friedlander, Matthew D. Smith, Tomas Huber, Ivan Huang, Josef A. Dunbar, Christopher B. Eiben, Justin B. Siegel, Jeremy H. Mills, David M. Zong, Jeff Nivala
Publikováno v:
The Journal of Biological Chemistry
Past anthrax attacks in the United States have highlighted the need for improved measures against bioweapons. The virulence of anthrax stems from the shielding properties of the Bacillus anthracis poly-γ-d-glutamic acid capsule. In the presence of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7d41a5ed8b445b06f0d55dc13fcafc
http://europepmc.org/articles/PMC3173206
http://europepmc.org/articles/PMC3173206
Autor:
Leonard A. Smith, Rowena D Schokman, Changhong Y. Lindsey, Ralph Tammariello, John H. Carra, Richard E. Dinterman, Robert W. Wannemacher
Publikováno v:
Vaccine. 25:4149-4158
Ricin is a potent toxin associated with bioterrorism for which no vaccine or specific countermeasures are currently available. A stable, non-toxic and immunogenic recombinant ricin A-chain vaccine (RTA 1-33/44-198) has been developed by protein engin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bab6de2a9d90600719503038d8f338
https://doi.org/10.1016/j.vaccine.2007.03.011
https://doi.org/10.1016/j.vaccine.2007.03.011
Autor:
John H. Carra, Sina Bavari, Jesse T. Steffens, Karen A. Martins, Rowena D Schokman, Camenzind G. Robinson
Publikováno v:
Journal of Translational Medicine
Background Filovirus virus-like particles (VLP) are strong immunogens with the potential for development into a safe, non-infectious vaccine. However, the large size and filamentous structure of this virus has heretofore made production of such a vac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d743de1190381438c3706d773d796f3e
https://pubmed.ncbi.nlm.nih.gov/26174690
https://pubmed.ncbi.nlm.nih.gov/26174690
Autor:
Shirin S. Badie, Melodi P. Javid, George Kallstrom, M. Javad Aman, Tam Luong Nguyen, Timothy Nelle, Gretchen L. Demmin, Rowena D Schokman, Sina Bavari, Gordon Ruthel, John H. Carra, Amy B. Will
Publikováno v:
BASE-Bielefeld Academic Search Engine
Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for many viruses. A variety of viral proteins have been i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8668a889659fc5cccf63314214aae50f
https://doi.org/10.1128/jvi.79.8.4709-4719.2005
https://doi.org/10.1128/jvi.79.8.4709-4719.2005
Autor:
Sina Bavari, Chella S. David, Luis DaSilva, John H. Carra, Juli Hanson, M. Javad Aman, Brent C. Welcher
Publikováno v:
The Journal of Infectious Diseases. 186:501-510
Streptococcal and staphylococcal infections result in significant human morbidity and mortality. This study used a transgenic murine model expressing human major histocompatibility complex (MHC) class II and human CD4 in which, without additional tox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c32cf82632d8063b3a8db730c9948df
https://doi.org/10.1086/341828
https://doi.org/10.1086/341828
Autor:
John H. Carra, Peter L. Privalov
Publikováno v:
Biochemistry. 34:2034-2041
In a continuation of an earlier study [Carra, J., Anderson, E., & Privalov, P. (1994) Biochemistry 33, 10842-10850], we used differential scanning calorimetry to measure the enthalpy and heat capacity changes of denaturation for 11 mutant forms of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c84d68cd7356ee4b7bbc7cf25330de
https://doi.org/10.1021/bi00006a025
https://doi.org/10.1021/bi00006a025
Publikováno v:
Biochemistry. 33:10842-10850
Using microcalorimetry, we found an equilibrium intermediate state during the denaturation of the wild-type and five mutant staphylococcal nuclease proteins: V66L, V66W, G88V, D77A, and E75V. The presence of two distinct heat absorption peaks allowed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c5e68a84b5925950d9a721a3fe1429
https://doi.org/10.1021/bi00201a035
https://doi.org/10.1021/bi00201a035
Publikováno v:
Protein Science. 3:944-951
Using high-sensitivity differential scanning calorimetry, we reexamined the thermodynamics of denaturation of staphylococcal nuclease. The denaturational changes in enthalpy and heat capacity were found to be functions of both temperature and pH. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c745dce48e78e81cba121ab20f983d51
https://doi.org/10.1002/pro.5560030609
https://doi.org/10.1002/pro.5560030609