Zobrazeno 1 - 10
of 296
pro vyhledávání: '"John H. Byrne"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Costa et al. use single-neuron resolution voltage imaging to identify two low-dimensional motor modules in the neuronal population underlying Aplysia feeding. Their findings point to a temporal shift in module recruitment as the primary signature of
Externí odkaz:
https://doaj.org/article/41a3e48e60654cbea194c53d04903ef1
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract Kinases play critical roles in synaptic and neuronal changes involved in the formation of memory. However, significant gaps exist in the understanding of how interactions among kinase pathways contribute to the mechanistically distinct tempo
Externí odkaz:
https://doaj.org/article/2f0a01c4d61d455fa22bb029442d5f0b
Publikováno v:
Frontiers in Computational Neuroscience, Vol 14 (2020)
A fundamental neuroscience question is how memories are maintained from days to a lifetime, given turnover of proteins that underlie expression of long-term synaptic potentiation (LTP) or “tag” synapses as eligible for LTP. A likely solution reli
Externí odkaz:
https://doaj.org/article/2f4683c890504b69a5524b7a8921b9f4
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Doxorubicin (DOX), a common chemotherapeutic agent, impairs synaptic plasticity. DOX also causes a persistent increase in basal neuronal excitability, which occludes serotonin-induced enhanced excitability. Therefore, we sought to characteri
Externí odkaz:
https://doaj.org/article/9085c26eb1104bab9ba19e4f21ed459b
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010239 (2022)
Key features of long-term memory (LTM), such as its stability and persistence, are acquired during processes collectively referred to as consolidation. The dynamics of biological changes during consolidation are complex. In adult rodents, consolidati
Externí odkaz:
https://doaj.org/article/ce84d98358414293bffdb05b0ef3b7f5
Publikováno v:
Learning & Memory. 29:435-446
Empirical and computational methods were combined to examine whether individual or dual-drug treatments can restore the deficit in long-term synaptic facilitation (LTF) of theAplysiasensorimotor synapse observed in a cellular model of Coffin–Lowry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e9abb4f78c84f076acc07b17501218
https://doi.org/10.1101/lm.053625.122
https://doi.org/10.1101/lm.053625.122
An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerv
Mechanisms of specific memory deficits associated with Rett syndrome are poorly understood, at least in part because mutations ofMECP2have confounding effects on nervous system development and basal synaptic transmission. To mitigate such empirical u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a47ec652389e32cae90b49d23ad4b3d9
https://doi.org/10.1101/2022.10.25.513721
https://doi.org/10.1101/2022.10.25.513721
Publikováno v:
Oxford Open Neuroscience. 2
Phosphorylation of the MAPK family member extracellular signal–regulated kinase (ERK) is required to induce long-term synaptic plasticity, but little is known about its persistence. We examined ERK activation by three protocols that induce long-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7dc3fd04d282deba5003981367f4324
https://doi.org/10.1093/oons/kvac014
https://doi.org/10.1093/oons/kvac014
The mitogen-activated protein kinase (MAPK) isoform extracellular signal–regulated kinase (ERK) is a key kinase involved in the induction of long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse. Therefore, elucidating the dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7100923b05d8fc5e8be057a61b3a3c5f
https://doi.org/10.1101/2022.08.05.502983
https://doi.org/10.1101/2022.08.05.502983