Zobrazeno 1 - 10 of 51 pro vyhledávání: '"John H. Bateson"'
1
SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849
Autor: Alison I. Muir, Shelagh Wilson, Christopher N. Johnson, Kim Winborn, Alex J. Stevens, Guillaume J. Hervieu, Peter J. O'Hanlon, Phillip Jeffrey, John H. Bateson, Kevin M. Thewlis, David R. Witty, Geoffrey Stemp
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:4865-4871
We report here the discovery of a class of MCH R1 ligands based on a biphenyl carboxamide template. A docked-in model is presented indicating key interactions in the putative binding site of the receptor. Parallel high throughput synthetic techniques
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe6fee21c10df4d340450ebe71920d0
https://doi.org/10.1016/j.bmcl.2006.06.056
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2
Thiocarbonyl-based 1,3-dipolarophiles for the synthesis of C(2)-unsubstituted penems
Autor: Timothy Gallagher, Sylvie Sanchez, John H. Bateson, Peter J. O'Hanlon
Publikováno v: Pure and Applied Chemistry. 77:2033-2040
The azomethine ylid strategy for β-lactam synthesis, which involves the fragmentation of a β-lactam-based oxazolidinone to give a carboxylated azomethine ylid, has been extended to the C(2)-unsubstituted penem scaffold associated with C(6)-exoalkyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bccc45c6a52396d15ae8dfcf24d8aeb7
https://doi.org/10.1351/pac200577122033
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3
Coordination Geometries of Metal Ions in D- or L-Captopril-inhibited Metallo-β-lactamases
Autor: John H. Bateson, Sandra Wommer, Uwe Heinz, Cyril Papamichaels, Hans-Werner Adolph, Rogert Bauer, Wolfram Meyer-Klaucke
Publikováno v: Journal of Biological Chemistry. 278:20659-20666
d- and l-captopril are competitive inhibitors of metallo-beta-lactamases. For the enzymes from Bacillus cereus (BcII) and Aeromonas hydrophila (CphA), we found that the mononuclear enzymes are the favored targets for inhibition. By combining results
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d951dafbf50eb6bbc586e16becaaf330
https://doi.org/10.1074/jbc.m212581200
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4
Characterization of Monomeric L1 Metallo-β-lactamase and the Role of the N-terminal Extension in Negative Cooperativity and Antibiotic Hydrolysis
Autor: Michael W. Crowder, Anne L. Carenbauer, Stephen E. Halford, Timothy R. Walsh, Anthony R. Clarke, Peter M. Bennett, John H. Bateson, Catherine S. Higgins, Alan M. Simm
Publikováno v: Journal of Biological Chemistry. 277:24744-24752
The L1 metallo-beta-lactamase from Stenotrophomonas maltophilia is unique among this class of enzymes because it is tetrameric. Previous work predicted that the two regions of important intersubunit interaction were the residue Met-140 and the N-term
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fb80158a92d293f039d8503e175eca
https://doi.org/10.1074/jbc.m201524200
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5
Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases
Autor: David G. Tew, Alfonso Rivera-Sagredo, Paloma Perez, Cheryl A. Janson, Nestor O. Concha, Martin Gilpin, Juan A. Hueso-Rodríguez, Michael Rees, John H. Bateson, Jesús Ángel de la Fuente, Helen F. Boyd, Niconovich Nancy, Stewart C. Pearson, Christy Cheever, David J. Payne, E. Diez, Stephen Rittenhouse
Publikováno v: Antimicrobial Agents and Chemotherapy. 46:1880-1886
Metallo-β-lactamases provide bacteria with an efficient and effective way of mediating resistance to β-lactam-based antibacterial agents. More significantly, they confer resistance to carbapenems. Therefore, if metallo-β-lactamases increase in pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9aa937c16cee0ca888b0a557de1cdef
https://doi.org/10.1128/aac.46.6.1880-1886.2002
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6
Synthesis and antibacterial activity of some C-3-lactonyl substituted cephalosporins
Autor: John H. Bateson, George Burton, Stephen Christopher Martin Fell
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:2219-2224
In continuation of our studies of cephalosporins containing novel cyclic-3-substituents, 1 we now report the synthesis of some lactones connected to the cephalosporin dihydrothiazine ring either directly, or through a single carbon spacer.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4850a443e314ceba989bea388fcc5138
https://doi.org/10.1016/s0960-894x(01)80928-8
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7
6-Spirocyclopropyl penems
Autor: John H. Bateson, Angela W. Guest
Publikováno v: Tetrahedron Letters. 34:1799-1802
6-Alkylidene penems were found to react with diazomethane to give pyrazolines, which were thermolysed to afford the title compounds.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71c0cea6edd33db797a66364c0282297
https://doi.org/10.1016/s0040-4039(00)60783-9
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9
ChemInform Abstract: Stereochemistry of Substituted 1-Alkoxybicyclo(2.2.2)octenes; Diels- Alder Synthesis versus Tandem-Michael Strategy
Autor: J. B. Wilkinson, C. F. Smith, John H. Bateson
Publikováno v: ChemInform. 22
Diels-Alder reactions of 1-methoxy- and 1-ethoxy-cyclohexa-1,3-dienes with ethyl cinnamate or ethyl 4,4,4-trifluorocrotonate favour the (1RS,2RS,3SR,4RS) (exo-carboxylate) bicyclo [2.2.2] octene stereochemistry, whereas the bicyclo-octenes derived fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68856c68ddaf7ddda1af322a5bca334f
https://doi.org/10.1002/chin.199124115
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