Výsledky vyhledávání - "John H. B. Scarpello"

Autor: Harry C S Howlett, John H B Scarpello

Publikováno v: Diabetes and Vascular Disease Research. 5:157-167

Metformin is now established as a first-line antidiabetic therapy for the management of type 2 diabetes. Its early use in treatment algorithms is supported by lack of weight gain, low risk of hypoglycaemia and its mode of action to counter insulin re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9c45c711d8220f831655a236aa4caa
https://doi.org/10.3132/dvdr.2008.027

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Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?

Autor: Abd A. Tahrani, George I Varughese, John H. B. Scarpello, Fahmy W F Hanna

Publikováno v: BMJ. 335:508-512

Many patients with type 2 diabetes are denied treatment with metformin because of “contraindications” such as cardiac failure, which may not be absolute contraindications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbce35731ca441147202a06014899bb6
https://doi.org/10.1136/bmj.39255.669444.ae

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A one-year retrospective audit of the DIGAMI protocol

Autor: John H. B. Scarpello, David Barton, Harit Buch, George I Varughese, Ellen Hodgson

Publikováno v: The British Journal of Diabetes & Vascular Disease. 4:396-399

Aim To assess the impact of post-MI diabetes-care upon changes in diabetes therapy and on cardiovascular risk factors. Patients and methods Retrospective audit of case notes of patients with diabetes who were treated according to the DIGAMI protocol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adedd9428586831bc686ec49d6985618
https://doi.org/10.1177/14746514040040060601

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Expression and functional activity of PPARγ in pancreatic β cells

Autor: Noel G. Morgan, Hannah J. Welters, Stephen A. Smith, Moh Tadayyon, John H. B. Scarpello, Stuart C McBain

Publikováno v: British Journal of Pharmacology. 142:1162-1170

Rosiglitazone is an agonist of peroxisome proliferator activated receptor-γ (PPARγ) and ameliorates insulin resistance in type II diabetes. In addition, it may also promote increased pancreatic β-cell viability, although it is not known whether th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8be5b1838c62e1670db26c70000661d
https://doi.org/10.1038/sj.bjp.0705844

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Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells

Autor: Moh Tadayyon, Noel G. Morgan, Hannah J. Welters, Stephen A. Smith, John H. B. Scarpello

Publikováno v: Journal of Molecular Endocrinology. 32:227-235

Chronic exposure of pancreatic beta-cells to saturated fatty acids leads to loss of viability, an effect that has been implicated in the process of beta-cell 'lipotoxicity' associated with the progression of type 2 diabetes. The mechanisms involved a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19bb532704f11adad998fe3f491ff25
https://doi.org/10.1677/jme.0.0320227

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Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure

Autor: Stephen A. Smith, John H. B. Scarpello, Hannah J. Welters, Moh Tadayyon, Noel G. Morgan

Publikováno v: FEBS Letters. 560:103-108

Long-chain saturated fatty acids are cytotoxic to pancreatic beta-cells while shorter-chain saturated and long-chain unsaturated molecules are better tolerated. Mono-unsaturated fatty acids are not, however, inert since they inhibit the pro-apoptotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf29855702b06bc952e61ccac39f551
https://doi.org/10.1016/s0014-5793(04)00079-1

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Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic β-cell line, RINm5F

Autor: John H. B. Scarpello, Noel G. Morgan, Jim Elliott

Publikováno v: British Journal of Pharmacology. 132:119-126

1. Sodium fluoride causes apoptosis of pancreatic beta-cells and this response is enhanced by pre-treatment with pertussis toxin. In the present study, tyrosine kinase inhibitors were used to investigate the mechanisms of action of NaF and pertussis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::275d7ceb31a2ca699a28474a29ff6f52
https://doi.org/10.1038/sj.bjp.0703783

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Dissociation between Fas expression and induction of apoptosis in human islets of Langerhans

Autor: Gwyn T. Williams, Noel G. Morgan, John H. B. Scarpello, Anne C. Loweth, Stuart C McBain, K. Watts

Publikováno v: Diabetes, Obesity and Metabolism. 2:57-60

There is increasing evidence that inappropriate induction of apoptosis in pancreatic beta-cells may precede the development of type 1 diabetes in animal models and in man. One mechanism by which this has been proposed to occur involves up-regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490345484922184fe8dbf6fdca1bea3b
https://doi.org/10.1046/j.1463-1326.2000.00068.x

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Mortality rates in hospital patients with hyperglycaemia and MRSA bacteraemia

Autor: Jeorge M Orendi, John H. B. Scarpello, Harit Buch, George I Varughese, Kostos Miltsios

Publikováno v: The British Journal of Diabetes & Vascular Disease. 6:42-44

Methicillin Resistant Staphylococcus Aureus (MRSA) infections in the hospital population have shown a dramatic increase. This pilot study determined whether random/fasting blood glucose measurements were performed on patients admitted to hospital wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bf30c92e0999f6bc3454f959eac13ee
https://doi.org/10.1177/14746514060060010501

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