Zobrazeno 1 - 10
of 13
pro vyhledávání: '"John H. A. Stibbard"'
Autor:
Georgette Castanedo, Shirley A. Brunton, Susan Wong, James C. Marsters, Lesley J. Murray, Laurent Salphati, Karen Kotkow, Cyrus Khojasteh, Kevin Lau, Stanley Mark S, Michael F. T. Koehler, Dina Michael S, Lee L. Rubin, Wei Jia, Hank La, Daniel P. Sutherlin, Leslie Lee, Shumei Wang, Jason Halladay, Changgeng Qian, John H. A. Stibbard, Savita Ubhayaker, Janet L. Gunzner, Kirk Robarge, Stephen E. Gould, Oivin Guichert, Minli Xie, Lalonde Rebecca, Richard Goldsmith, Yong Cui, Derek Marshall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5576-5581
SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e862c173e6b7fb83ca5bda975f9f516c
https://doi.org/10.1016/j.bmcl.2009.08.049
https://doi.org/10.1016/j.bmcl.2009.08.049
Autor:
John H. A. Stibbard, Lee L. Rubin, Raffaella Di Lucrezia, Shirley A. Brunton, Stephen Price, Edward Andrew Boyd, L. I. Kruse, Oivin M. Guicherit, Alaric Avery, Colin H. MacKinnon, Danielle Buxton, Yvonne Park
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fca7d5f894a95789f0f284f494ed03d
https://pubmed.ncbi.nlm.nih.gov/19500978
https://pubmed.ncbi.nlm.nih.gov/19500978
Autor:
Janet L. Gunzner, Dina Michael S, Laurent Salphati, Karen Kotkow, James C. Marsters, Richard Goldsmith, Lesley J. Murray, Yong Cui, Hank La, Wei Jia, Jason Halladay, Kirk Robarge, Daniel P. Sutherlin, Lalonde Rebecca, Derek Marshall, Savita Ubhayaker, Shirley A. Brunton, Changgeng Qian, John H. A. Stibbard, Georgette Castanedo, Susan Wong, Leslie Lee, Cyrus Khojasteh, Lee L. Rubin, Shumei Wang, Stanley Mark S, Michael F. T. Koehler, Kevin Lau, Stephen E. Gould, Oivin Guichert, Minli Xie
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:771
Kirk D. Robarge *, Shirley A. Brunton , Georgette M. Castanedo , Yong Cui , Michael S. Dina , Richard Goldsmith , Stephen E. Gould , Oivin Guichert , Janet L. Gunzner , Jason Halladay , Wei Jia , Cyrus Khojasteh , Michael F. T. Koehler , Karen Kotkow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6abc5f52cbbd6cce8c4952ab00ea8953
https://doi.org/10.1016/j.bmcl.2009.11.129
https://doi.org/10.1016/j.bmcl.2009.11.129
Publikováno v:
Tetrahedron Letters. 23:2407-2410
The synthesis of the cis-fused γ-lactone 2,7-dioxabicyclo-[4,3,0]non-4-en-8-one (3) by two routes is reported. Its stereoselective conversion to a key intermediate for pseudomonic acid synthesis is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7f7d6c64b88af15770c33539fd4be13
https://doi.org/10.1016/s0040-4039(00)87354-2
https://doi.org/10.1016/s0040-4039(00)87354-2
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2159-2164
A new, convenient, and stereoselective route to a central intermediate in pseudomonic acid synthesis via the cis-fused γ-lactone, 2,7-dioxabicyclo[4.3.0]non-4-en-8-one (3), is described. The required relative stereochemistry of the 2- and 5-side cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a749f27e65e7501385409ad27aa47d51
https://doi.org/10.1039/p19840002159
https://doi.org/10.1039/p19840002159
Autor:
Shirley A. Brunton, John H. A. Stibbard, Lee L. Rubin, Lawrence I. Kruse, Oivin M. Guicherit, Edward A. Boyd, Steven Price
Publikováno v:
Journal of Medicinal Chemistry; Feb2008, Vol. 51 Issue 5, p1108-1110, 3p
The 2,3,5-tris (methylene)norbornane adds to methyl propynoate with “para” regioselectivity. This principle is applied to the regioselective synthesis of a daunomycinone precursor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01895e2a483c099e7736340131b512c6
https://infoscience.epfl.ch/record/59467
https://infoscience.epfl.ch/record/59467
Autor:
Pierre Vogel, Dieter Schwarzenbach, Pierre-Alain Carrupt, John H. A. Stibbard, Alan A. Pinkerton
Publikováno v:
Journal of the American Chemical Society, Vol. 103, No 8 (1981) pp. 2095-2096
Note: Univ lausanne,inst chim organ,ch-1005 lausanne,switzerland. inst cristallo batiment sci phys,ch-1015 lausanne dorigny,switzerland. Reference LGSA-ARTICLE-1981-005doi:10.1021/ja00398a039 Record created on 2005-11-09, modified on 2017-05-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a560256c8f7abb8cd36f4c514a1047e
https://doi.org/10.1021/ja00398a039
https://doi.org/10.1021/ja00398a039
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :761
Electrochemical reduction of bridged 1,5-benzodiazepines, condensation products of o-phenylenediamines with 4,6-dimethylbicyclo[3.3.1]nona-3,6-diene-2,8-dione, has been studied. Cathodic acylation of 4,6-dimethyl-5,2,8-ethanylylidene-5H-1,9-benzodiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e801ed9141ebdaf6873b11e6c64492
https://doi.org/10.1039/c39790000761
https://doi.org/10.1039/c39790000761
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :557
o-Phenylenediamines react with 4,6-dimethylbicyclo[3.3.1]nona-3,6-diene-2,8-dione to give 1,5-benzodiazepines; physical and chemical properties of the bridged imines are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c57deb3b6c2758779562658b51b107e
https://doi.org/10.1039/c39780000557
https://doi.org/10.1039/c39780000557