Zobrazeno 1 - 10
of 225
pro vyhledávání: '"John H Wolfe"'
Autor:
Wenpei Liu, Gerald Griffin, Trena Clarke, Michael K Parente, Rita J Valentino, John H Wolfe, Nigel W Fraser
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
Genetic diseases of the brain usually have pathologic lesions distributed throughout, thus requiring global correction. Herpes simplex virus-1 (HSV-1) vectors may be especially useful for gene delivery in these disorders since they can spread trans-s
Externí odkaz:
https://doaj.org/article/6b25cb0a96534986944aec5ede82ecf5
Autor:
Sea Young Yoon, Carlos Gay-Antaki, Datta E Ponde, Harish Poptani, Charles H Vite, John H Wolfe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
In vivo imaging of vector transgene expression would be particularly valuable for repetitive monitoring of therapy in the brain, where invasive tissue sampling is contraindicated. We evaluated adeno-associated virus vector expression of a dopamine-2
Externí odkaz:
https://doaj.org/article/400dc2e2cf0145adb269b37308de9ce3
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32419 (2012)
The characteristic neurological feature of many neurogenetic diseases is intellectual disability. Although specific neuropathological features have been described, the mechanisms by which specific gene defects lead to cognitive impairment remain obsc
Externí odkaz:
https://doaj.org/article/8e8837dffe98496db5584531db62b444
Autor:
Jacqueline E. Hunter, Caitlyn M. Molony, Jessica H. Bagel, Patricia O’Donnell, Charles H. Vite, Sanjeev Chawla, Harish Poptani, John H. Wolfe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101272- (2024)
Alpha-mannosidosis is caused by a genetic deficiency of lysosomal alpha-mannosidase, leading to the widespread presence of storage lesions in the brain and other tissues. Enzyme replacement therapy is available but is not approved for treating the CN
Externí odkaz:
https://doaj.org/article/32143ef83a1245e2aafcf6401173762a
Autor:
Faez Siddiqi, Alexandria L Trakimas, Donald J. Joseph, Margaret L Lippincott, John H. Wolfe, Eric D. Marsh
Publikováno v:
Cereb Cortex
Cortical interneurons (GABAergic cells) arise during embryogenesis primarily from the medial and caudal ganglionic eminences (MGE and CGE, respectively) with a small population generated from the preoptic area (POA). Progenitors from the lateral gang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2c1a0ad1295218f9e3546c167d0699
https://doi.org/10.1093/cercor/bhab152
https://doi.org/10.1093/cercor/bhab152
Autor:
Manoj Kumar, Dana L. Clarke, Charles H. Vite, Caitlyn Molony, Patricia O'Donnell, Sanjeev Chawla, Harish Poptani, John H. Wolfe, Sea Young Yoon, Jessica H. Bagel, Jacqueline E Hunter
Publikováno v:
Brain
BRAIN
BRAIN
Intravascular injection of certain adeno-associated virus vector serotypes can cross the blood–brain barrier to deliver a gene into the CNS. However, gene distribution has been much more limited within the brains of large animals compared to rodent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5d0c0588e3124c416953e0eb832af6
https://doi.org/10.1093/brain/awaa161
https://doi.org/10.1093/brain/awaa161
Autor:
Ana Ripolles-Garcia, Natalia Dolgova, M. Joseph Phillips, Svetlana Savina, Allison L. Ludwig, Sara A. Stuedemann, Uchenna Nlebedum, John H. Wolfe, Oliver A. Garden, Arvydas Maminishkis, Juan Amaral, Kapil Bharti, David M. Gamm, Gustavo D. Aguirre, William A. Beltran
Publikováno v:
Stem cell reports. 17(8)
Regenerative therapies aimed at replacing photoreceptors are a promising approach for the treatment of otherwise incurable causes of blindness. However, such therapies still face significant hurdles, including the need to improve subretinal delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8b1b9dfc1e11972cf888bf900ad963
https://pubmed.ncbi.nlm.nih.gov/35905738
https://pubmed.ncbi.nlm.nih.gov/35905738
Autor:
Jacqueline E. Hunter, Caitlyn M. Molony, Jessica H. Bagel, Patricia A. O’Donnell, Stephen G. Kaler, John H. Wolfe
Publikováno v:
Molecular therapy. Methodsclinical development. 26
Multiple studies have examined the transduction characteristics of different AAV serotypes in the mouse brain, where they can exhibit significantly different patterns of transduction. The pattern of transduction also varies with the route of administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2dbf54610e0d6279d7970e38f218fd
https://pubmed.ncbi.nlm.nih.gov/36034772
https://pubmed.ncbi.nlm.nih.gov/36034772
Autor:
Mark Jackson, Nigel B. Wood, Shunzhi Zhao, Alexander Augst, John H. Wolfe, Wladyslaw M.W. Gedroyc, Alun D. Hughes, Simon A.McG. Thom, Xiao Y. Xu
Publikováno v:
Artery Research, Vol 3, Iss 1 (2009)
Background: Venous grafts commonly develop myointimal hyperplasia, which can lead to stenoses and, ultimately, with expression of adhesion molecules, lumenal occlusion. The aim of the present study was to investigate whether wall shear stress measure
Externí odkaz:
https://doaj.org/article/e1d65245dbb54b7aab59098247cbb330