Zobrazeno 1 - 10
of 43
pro vyhledávání: '"John H Sinclair"'
Autor:
Timo W. M. De Groof, Elizabeth G. Elder, Eleanor Y. Lim, Raimond Heukers, Nick D. Bergkamp, Ian J. Groves, Mark Wills, John H. Sinclair, Martine J. Smit
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Human cytomegalovirus (HCMV) can evade immune responses in latent reservoirs, which is a specific problem during transplantation. Here the authors develop a bivalent nanobody that is specific for US28, a viral receptor required by latent HCMV, and sh
Externí odkaz:
https://doaj.org/article/f6e7b525a9434aba8b55e7c5d8bcbd9e
Autor:
Sarah E. Jackson, George X. Sedikides, Veronika Romashova, Georgina Okecha, Ester B. M. Remmerswaal, Frederike J. Bemelman, John H. Sinclair, Mark R. Wills
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1530 (2022)
HCMV-specific CD8+ T-cells are potent anti-viral effector cells in HCMV infected individuals, but evidence from other viral infections suggests that CD8+ T-cells can also produce the immunomodulatory cytokine IL-10. In this work we show that there ar
Externí odkaz:
https://doaj.org/article/97e1dc3c06b840ab84bb43b3089f9a30
Autor:
Marianne R. Perera, John H. Sinclair
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11017 (2022)
Human cytomegalovirus (HCMV) is a significant source of disease for the immunosuppressed and immunonaive. The treatment of HCMV is made more problematic by viral latency, a lifecycle stage in which the virus reduces its own gene expression and produc
Externí odkaz:
https://doaj.org/article/e124fb1271594ee681de9ed4d06ab9c4
Autor:
Sarah E. Jackson, Kevin C. Chen, Ian J. Groves, George X. Sedikides, Amar Gandhi, Charlotte J. Houldcroft, Emma L. Poole, Inmaculada Montanuy, Gavin M. Mason, Georgina Okecha, Matthew B. Reeves, John H. Sinclair, Mark R. Wills
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Human cytomegalovirus (HCMV) infection is not cleared by the initial immune response but persists for the lifetime of the host, in part due to its ability to establish a latent infection in cells of the myeloid lineage. HCMV has been shown to manipul
Externí odkaz:
https://doaj.org/article/e97d64960ba34f25aabbe32eb204d4f4
Autor:
Marianne R, Perera, Edward Jd, Greenwood, Thomas Wm, Crozier, Elizabeth G, Elder, Janika, Schmitt, Colin M, Crump, Paul J, Lehner, Mark R, Wills, John H, Sinclair
Publikováno v:
The Journal of Infectious Diseases. 227:543-553
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate that prior infection with human
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Although the ubiquitous human herpesviruses (HHVs) are rarely associated with serious disease of the healthy host, primary infection and reactivation in immunocompromised individuals can lead to significant morbidity and, in some cases, mortality. Ef
Externí odkaz:
https://doaj.org/article/9ebaf0da7ce44f52b4fd35f689cabf6e
Publikováno v:
Viruses, Vol 14, Iss 2, p 246 (2022)
Long non-coding RNA β2.7 is the most highly transcribed viral gene during latent human cytomegalovirus (HCMV) infection. However, as yet, no function has ever been ascribed to β2.7 during HCMV latency. Here we show that β2.7 protects against apopt
Externí odkaz:
https://doaj.org/article/88583671ca0d4c569f6af0de7213d7c6
Autor:
Emma L. Poole, Verity G. Kew, Jonathan C.H. Lau, Matthew J. Murray, Thomas Stamminger, John H. Sinclair, Matthew B. Reeves
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 594-606 (2018)
Summary: A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML bodies during
Externí odkaz:
https://doaj.org/article/1450d54d064849baba4c0995a9d64c52
Autor:
Gisele F Bomfim, Fernanda Priviero, Emma Poole, Rita C Tostes, John H Sinclair, Dimitrios Stamou, Mark J Uline, Mark R Wills, R Clinton Webb
Publikováno v:
American Journal of Hypertension.
Cytomegalovirus (CMV) is a member of the β-herpesviruses and is ubiquitous, infecting 50%–99% of the human population depending on ethnic and socioeconomic conditions. CMV establishes lifelong, latent infections in their host. Spontaneous reactiva
Publikováno v:
Viruses, Vol 13, Iss 5, p 817 (2021)
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage. However, HCMV often causes severe d
Externí odkaz:
https://doaj.org/article/4474cbb7cd704d889179cb285cd189c3