Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John H J Petrini"'
Autor:
Marcel Hohl, Aditya Mojumdar, Sarem Hailemariam, Vitaly Kuryavyi, Fiorella Ghisays, Kyle Sorenson, Matthew Chang, Barry S Taylor, Dinshaw J Patel, Peter M Burgers, Jennifer A Cobb, John H J Petrini
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008422 (2020)
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor su
Externí odkaz:
https://doaj.org/article/388c6d982e6748dbb8481de967c8f5ac
Autor:
Guochang Huang, Andrew J Kaufman, Russell J H Ryan, Yevgeniy Romin, Laryssa Huryn, Sarina Bains, Katia Manova-Todorova, Patricia L Morris, Gary R Hunnicutt, Carrie A Adelman, John H J Petrini, Y Ramanathan, Bhuvanesh Singh
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209995 (2019)
Squamous cell carcinoma-related oncogene (SCCRO, also known as DCUN1D1) is a component of the E3 for neddylation. As such, DCUN1D1 regulates the neddylation of cullin family members. Targeted inactivation of DCUN1D1 in mice results in male-specific i
Externí odkaz:
https://doaj.org/article/b2c5cb5ef6f94ce8bb3cf00f8422e4c2
Autor:
Bari J Ballew, Vijai Joseph, Saurav De, Grzegorz Sarek, Jean-Baptiste Vannier, Travis Stracker, Kasmintan A Schrader, Trudy N Small, Richard O'Reilly, Chris Manschreck, Megan M Harlan Fleischut, Liying Zhang, John Sullivan, Kelly Stratton, Meredith Yeager, Kevin Jacobs, Neelam Giri, Blanche P Alter, Joseph Boland, Laurie Burdett, Kenneth Offit, Simon J Boulton, Sharon A Savage, John H J Petrini
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003695 (2013)
Dyskeratosis congenita (DC) is a heterogeneous inherited bone marrow failure and cancer predisposition syndrome in which germline mutations in telomere biology genes account for approximately one-half of known families. Hoyeraal Hreidarsson syndrome
Externí odkaz:
https://doaj.org/article/8227b26c0dbc4b9aa78d97185bee92cb
Autor:
Lara Wohlbold, Karl A Merrick, Saurav De, Ramon Amat, Jun Hyun Kim, Stéphane Larochelle, Jasmina J Allen, Chao Zhang, Kevan M Shokat, John H J Petrini, Robert P Fisher
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002935 (2012)
The cyclin-dependent kinases (CDKs) that promote cell-cycle progression are targets for negative regulation by signals from damaged or unreplicated DNA, but also play active roles in response to DNA lesions. The requirement for activity in the face o
Externí odkaz:
https://doaj.org/article/4583e76d2d83486286803948df0db12a
Autor:
Courtney A Lovejoy, Wendi Li, Steven Reisenweber, Supawat Thongthip, Joanne Bruno, Titia de Lange, Saurav De, John H J Petrini, Patricia A Sung, Maria Jasin, Joseph Rosenbluh, Yaara Zwang, Barbara A Weir, Charlie Hatton, Elena Ivanova, Laura Macconaill, Megan Hanna, William C Hahn, Neal F Lue, Roger R Reddel, Yuchen Jiao, Kenneth Kinzler, Bert Vogelstein, Nickolas Papadopoulos, Alan K Meeker, ALT Starr Cancer Consortium
Publikováno v:
PLoS Genetics, Vol 8, Iss 7, p e1002772 (2012)
The Alternative Lengthening of Telomeres (ALT) pathway is a telomerase-independent pathway for telomere maintenance that is active in a significant subset of human cancers and in vitro immortalized cell lines. ALT is thought to involve templated exte
Externí odkaz:
https://doaj.org/article/f6be43954a08419ba9c14310d32fca47
Autor:
Carrie A Adelman, John H J Petrini
Publikováno v:
PLoS Genetics, Vol 4, Iss 3, p e1000042 (2008)
We have recently shown that hypomorphic Mre11 complex mouse mutants exhibit defects in the repair of meiotic double strand breaks (DSBs). This is associated with perturbation of synaptonemal complex morphogenesis, repair and regulation of crossover f
Externí odkaz:
https://doaj.org/article/2845dba5173a428f8b64b2cee516be0a
Autor:
Jan Karlseder, Kristina Hoke, Olga K Mirzoeva, Christopher Bakkenist, Michael B Kastan, John H J Petrini, Titia de Lange
Publikováno v:
PLoS Biology, Vol 2, Iss 8, p E240 (2004)
The telomeric protein TRF2 is required to prevent mammalian telomeres from activating DNA damage checkpoints. Here we show that overexpression of TRF2 affects the response of the ATM kinase to DNA damage. Overexpression of TRF2 abrogated the cell cyc
Externí odkaz:
https://doaj.org/article/311ddc568a6543bbb824eeaa9500bf4d
Publikováno v:
BioEssays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fc16793d14f3cf9ba939fc0011316dc
https://doi.org/10.1002/bies.202300042
https://doi.org/10.1002/bies.202300042
Autor:
Keith Conrad Fernandez, Laura Feeney, Ryan M. Smolkin, Wei-Feng Yen, Allysia J. Matthews, John H. J. Petrini, Jayanta Chaudhuri
During the development of humoral immunity, activated B lymphocytes undergo vigorous proliferative, transcriptional, metabolic, and DNA remodeling activities; hence, their genomes are constantly exposed to an onslaught of genotoxic agents and process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ecb5b593072d0ce512b7fa85b4d6613
https://doi.org/10.1101/2022.02.09.479711
https://doi.org/10.1101/2022.02.09.479711
Publikováno v:
Proceedings of the National Academy of Sciences. 87:3450-3453
The severe combined immune deficient (scid) mouse mutant is characterized by a general absence of functional B and T lymphocytes. This deficiency appears to result from a defect in the variable-diversity-joining (VDJ) recombinase system, which is res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dece9703bb8dbad5080436fa92b5b65
https://doi.org/10.1073/pnas.87.9.3450
https://doi.org/10.1073/pnas.87.9.3450