Zobrazeno 1 - 10
of 142
pro vyhledávání: '"John H Bushweller"'
Autor:
Jason P. Wray, Elitza M. Deltcheva, Charlotta Boiers, Simon Е Richardson, Jyoti Bikram Chhetri, John Brown, Sladjana Gagrica, Yanping Guo, Anuradha Illendula, Joost H. A. Martens, Hendrik G. Stunnenberg, John H. Bushweller, Rachael Nimmo, Tariq Enver
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The ETV6-RUNX1 chimeric- and native RUNX1-responsive regulomes in paediatric B-acute lymphoblastic leukemia (B-ALL) remain to be characterized. Here, the authors reveal functional antagonism between the two transcription factors predominantly for the
Externí odkaz:
https://doaj.org/article/57a324404a3a49c69acb08a4d571d807
Autor:
Hanuman P. Kalmode, Izabella Podsiadly, Ashish Kabra, Adam Boulton, Prabhakar Reddy, Yan Gao, Christopher Li, John H. Bushweller
Publikováno v:
ACS medicinal chemistry letters. 13(8)
The CXXC domain is a reader of DNA methylation which preferentially binds to unmethylated CpG DNA motifs. Chromosomal translocations involving the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04f4edfd456ee084d3ef864f010e6ba
https://pubmed.ncbi.nlm.nih.gov/35978680
https://pubmed.ncbi.nlm.nih.gov/35978680
Autor:
Anuradha Illendula, Jane Gilmour, Jolanta Grembecka, Venkata Sesha Srimath Tirumala, Adam Boulton, Aravinda Kuntimaddi, Charles Schmidt, Lixin Wang, John A. Pulikkan, Hongliang Zong, Mahmut Parlak, Cem Kuscu, Anna Pickin, Yunpeng Zhou, Yan Gao, Lauren Mishra, Mazhar Adli, Lucio H. Castilla, Roger A. Rajewski, Kevin A. Janes, Monica L. Guzman, Constanze Bonifer, John H. Bushweller
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 117-131 (2016)
Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewa
Externí odkaz:
https://doaj.org/article/850cfca578ff44cc88f4d9d260010cb6
Autor:
Sharon A. Singh, Yu Wang, Lei Yu, Takashi Moriguchi, Chia Jui Ku, Julien Pedron, Masayuki Yamamoto, Michael G. Rosenfeld, John H. Bushweller, Greggory Myers, Natee Jearawiriyapaisarn, James Douglas Engel, Rami Khoriaty, Andrew White, Kim-Chew Lim, Emily Schneider
Publikováno v:
Blood. 138:1691-1704
Histone H3 lysine 4 methylation (H3K4Me) is most often associated with chromatin activation, and removing H3K4 methyl groups has been shown to be coincident with gene repression. H3K4Me demethylase KDM1a/LSD1 is a therapeutic target for multiple dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507aceaec274169cd30b2d883fad808b
https://doi.org/10.1182/blood.2021011682
https://doi.org/10.1182/blood.2021011682
Autor:
Aravinda Kuntimaddi, Nicholas J. Achille, Jeremy Thorpe, Alyson A. Lokken, Ritambhara Singh, Charles S. Hemenway, Mazhar Adli, Nancy J. Zeleznik-Le, John H. Bushweller
Publikováno v:
Cell Reports, Vol 11, Iss 5, Pp 808-820 (2015)
The MLL gene is a common target of chromosomal translocations found in human leukemia. MLL-fusion leukemia has a consistently poor outcome. One of the most common translocation partners is AF9 (MLLT3). MLL-AF9 recruits DOT1L, a histone 3 lysine 79 me
Externí odkaz:
https://doaj.org/article/47fe450047cb4afaa5f2ce1383e60300
Autor:
Molly A. Hughes, Katie R. Margulieux, Benjamin K. Liebov, Venkata S. K. K. S. Tirumala, Arpita Singh, John H. Bushweller, Robert K. Nakamoto
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
The antimicrobial activity of the chemokine CXCL10 against vegetative cells of Bacillus anthracis occurs via both bacterial FtsE/X-dependent and-independent pathways. Previous studies established that the FtsE/X-dependent pathway was mediated through
Externí odkaz:
https://doaj.org/article/dd01cd9dc7364f80a3a73dab6e05f097
Autor:
John H. Bushweller
Publikováno v:
J Mol Biol
The formation of disulfide bonds in proteins is an essential process in both prokaryotes and eukaryotes. In gram-negative bacteria including Escherichia coli, the proteins DsbA and DsbB mediate the formation of disulfide bonds in the periplasm. DsbA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4144252117d01c0d86e2e6eb25d1bb9
https://doi.org/10.1016/j.jmb.2020.04.008
https://doi.org/10.1016/j.jmb.2020.04.008
Autor:
Jane B. Lian, Jonathan A. R. Gordon, Nicole A. Bouffard, John H. Bushweller, Andrew J. Fritz, Joseph R. Boyd, Sayyed K. Zaidi, Gary S. Stein, Janet L. Stein, Anuradha Illendula, Joshua T. Rose, Eliana Moskovitz
Publikováno v:
Oncotarget
RUNX1 has recently been shown to play an important role in determination of mammary epithelial cell identity. However, mechanisms by which loss of the RUNX1 transcription factor in mammary epithelial cells leads to epithelial-to-mesenchymal transitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c22be5f0cadf1a1bce7aec2bfdde17
http://europepmc.org/articles/PMC7335667
http://europepmc.org/articles/PMC7335667
Autor:
Jane B. Lian, Jason Kost, Joseph R. Boyd, Mark Fitzgerald, Seth Frietze, Deli Hong, Alqassem Abuarqoub, Prachi N. Ghule, Miles Malik, Janet L. Stein, John H. Bushweller, Sayyed K. Zaidi, Andrew J. Fritz, Jonathan A. R. Gordon, Sebastian Hanna, Kristiaan H. Finstaad, Gary S. Stein, Coralee E. Tye
Publikováno v:
J Cell Physiol
Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and refractory to conventional therapies. Consequently BCSCs are implicated in tumor recurrence. Many signaling cascades associated with BCSCs are critical for epit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbfc0eb858b5dd7fd13c4948b57f8b9
https://doi.org/10.1002/jcp.29625
https://doi.org/10.1002/jcp.29625
Autor:
John H. Bushweller
Publikováno v:
Nat Rev Cancer
Mutated or dysregulated transcription factors represent a unique class of drug targets that mediate aberrant gene expression, including blockade of differentiation and cell death gene expression programmes, hallmark properties of cancers. Transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c48a25836432f4f4748861de6435a72
https://doi.org/10.1038/s41568-019-0196-7
https://doi.org/10.1038/s41568-019-0196-7