Zobrazeno 1 - 10
of 183
pro vyhledávání: '"John H Brumell"'
Autor:
Walter H. A. Kahr, Fred G. Pluthero, Abdul Elkadri, Neil Warner, Marko Drobac, Chang Hua Chen, Richard W. Lo, Ling Li, Ren Li, Qi Li, Cornelia Thoeni, Jie Pan, Gabriella Leung, Irene Lara-Corrales, Ryan Murchie, Ernest Cutz, Ronald M. Laxer, Julia Upton, Chaim M. Roifman, Rae S. M. Yeung, John H Brumell, Aleixo M Muise
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
ARPC1B is a component of the actin-related protein 2/3 complex (Arp2/3), which is required for actin filament branching. Kahret al. show that ARPC1B deficiency in humans is associated with severe multisystem disease that includes platelet abnormaliti
Externí odkaz:
https://doaj.org/article/eed6b90418cc417ea55ca5834ef97650
Autor:
Brandon Sit, Shauna M Crowley, Kirandeep Bhullar, Christine Chieh-Lin Lai, Calvin Tang, Yogesh Hooda, Charles Calmettes, Husain Khambati, Caixia Ma, John H Brumell, Anthony B Schryvers, Bruce A Vallance, Trevor F Moraes
Publikováno v:
PLoS Pathogens, Vol 11, Iss 8, p e1005107 (2015)
Efficient acquisition of extracellular nutrients is essential for bacterial pathogenesis, however the identities and mechanisms for transport of many of these substrates remain unclear. Here, we investigate the predicted iron-binding transporter AfuA
Externí odkaz:
https://doaj.org/article/8a537c844cf04e78a4e9b514d37279a5
Autor:
Hongxian Zhu, Andrew M. Sydor, Kirsten C. Boddy, Etienne Coyaud, Estelle M. N. Laurent, Aaron Au, Joel M. J. Tan, Bing-Ru Yan, Jason Moffat, Aleixo M. Muise, Christopher M. Yip, Sergio Grinstein, Brian Raught, John H. Brumell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection1. The effectors modulate host cell machinery to drive uptake of the bacteria into vacuoles, where they can establish
Externí odkaz:
https://doaj.org/article/cb972bdf39654deca965043e86fecd62
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125856 (2015)
Listeria monocytogenes is an intracellular bacterial pathogen that can replicate in the cytosol of host cells. These bacteria undergo actin-based motility in the cytosol via expression of ActA, which recruits host actin-regulatory proteins to the bac
Externí odkaz:
https://doaj.org/article/35d82c6343b54e818f748308b278980b
Autor:
Bernhard Roppenser, Hyunwoo Kwon, Veronica Canadien, Risheng Xu, Peter N Devreotes, Sergio Grinstein, John H Brumell
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71015 (2013)
SopB is a type 3 secreted effector with phosphatase activity that Salmonella employs to manipulate host cellular processes, allowing the bacteria to establish their intracellular niche. One important function of SopB is activation of the pro-survival
Externí odkaz:
https://doaj.org/article/5ad027cc9e2949bd9e0c705f1e514df3
Autor:
Ramzi Fattouh, Cong-Hui Guo, Grace Y Lam, Melanie G Gareau, Bo-Yee Ngan, Michael Glogauer, Aleixo M Muise, John H Brumell
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61629 (2013)
Recent genetic-based studies have implicated a number of immune-related genes in the pathogenesis of inflammatory bowel disease (IBD). Our recent genetic studies showed that RAC2 is associated with human IBD; however, its role in disease pathogenesis
Externí odkaz:
https://doaj.org/article/257e832d2d974e3eba67135d104855d0
Autor:
Colin A Cooper, Kun Zhang, Sara N Andres, Yuan Fang, Natalia A Kaniuk, Mandy Hannemann, John H Brumell, Leonard J Foster, Murray S Junop, Brian K Coombes
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000751 (2010)
Many Gram-negative bacteria colonize and exploit host niches using a protein apparatus called a type III secretion system (T3SS) that translocates bacterial effector proteins into host cells where their functions are essential for pathogenesis. A sui
Externí odkaz:
https://doaj.org/article/0392b8e9e1cf447893e09da759e1f57a
Autor:
Glenn F. W. Walpole, Jonathan Pacheco, Neha Chauhan, Jonathan Clark, Karen E. Anderson, Yazan M. Abbas, Danielle Brabant-Kirwan, Fernando Montaño-Rendón, Zetao Liu, Hongxian Zhu, John H. Brumell, Alexander Deiters, Len R. Stephens, Phillip T. Hawkins, Gerald R. V. Hammond, Sergio Grinstein, Gregory D. Fairn
Publikováno v:
Nature Cell Biology. 24:708-722
Despite their low abundance, phosphoinositides play a central role in membrane traffic and signalling. PtdIns(3,4,5)P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d77aec7fe2c7ac16d3ceec8f51a2663
https://doi.org/10.1038/s41556-022-00895-y
https://doi.org/10.1038/s41556-022-00895-y
Autor:
Samaneh Yazdani, Philip J. Bilan, Javier R. Jaldin-Fincati, Janice Pang, Felicia Ceban, Ekambir Saran, John H. Brumell, Spencer A. Freeman, Amira Klip
Publikováno v:
Molecular biology of the cell. 33(12)
We followed radioactive and fluorescent glucose derivatives in human microvascular endothelial cells (HAMEC). [3H]-2-DG entered via GLUT1/3 and 20% incorporated into glycogen. Glycogenolysis and 2-DG-6-phosphate provided glucose that exited cells via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9f757a1a7cc13d9123285865683a14
https://pubmed.ncbi.nlm.nih.gov/35921166
https://pubmed.ncbi.nlm.nih.gov/35921166
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-29 (2021)
BMC Biology
BMC Biology
Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment. To avoid lethal consequences, cells are equipped with repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba65c9f25931a2fa8b9e1e88e2491083
https://doaj.org/article/7a5b2f85a4134f3f8a10a03f3c5852a3
https://doaj.org/article/7a5b2f85a4134f3f8a10a03f3c5852a3