Zobrazeno 1 - 10
of 300
pro vyhledávání: '"John H Brumell"'
Autor:
Hongxian Zhu, Andrew M. Sydor, Kirsten C. Boddy, Etienne Coyaud, Estelle M. N. Laurent, Aaron Au, Joel M. J. Tan, Bing-Ru Yan, Jason Moffat, Aleixo M. Muise, Christopher M. Yip, Sergio Grinstein, Brian Raught, John H. Brumell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection1. The effectors modulate host cell machinery to drive uptake of the bacteria into vacuoles, where they can establish
Externí odkaz:
https://doaj.org/article/cb972bdf39654deca965043e86fecd62
Autor:
Angela Zou, Kerry Nadeau, Xuejian Xiong, Pauline W. Wang, Julia K. Copeland, Jee Yeon Lee, James St. Pierre, Maxine Ty, Billy Taj, John H. Brumell, David S. Guttman, Shayan Sharif, Doug Korver, John Parkinson
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-29 (2022)
Abstract Background The emergence of antimicrobial resistance is a major threat to global health and has placed pressure on the livestock industry to eliminate the use of antibiotic growth promotants (AGPs) as feed additives. To mitigate their remova
Externí odkaz:
https://doaj.org/article/6d4b495e9d134fd48213f78c981485ef
Autor:
Joel M. J. Tan, Monica E. Garner, James M. Regeimbal, Catherine J. Greene, Jorge D. Rojas Márquez, Dustin A. Ammendolia, Adam R. R. McCluggage, Taoyingnan Li, Katherine J. Wu, Marija Cemma, Philip P. Ostrowski, Brian Raught, Michael S. Diamond, Sergio Grinstein, Robin M. Yates, Darren E. Higgins, John H. Brumell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Interferon (IFN) is an important component of antiviral immunity, but can also be exploited by bacteria for immune evasion. Here the authors show that Listeria monocytogenes (Lm) induces type I IFN to suppress the degradation of Lm virulence proteins
Externí odkaz:
https://doaj.org/article/ec11a9708c984975be93768c9db2c7f1
Autor:
Kirsten C. Boddy, Hongxian Zhu, Vanessa M. D’Costa, Caishuang Xu, Ksenia Beyrakhova, Miroslaw Cygler, Sergio Grinstein, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Brian Raught, John H. Brumell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al. show that SopD binds to and inhibits the small GTPase Rab10, thus promoting removal
Externí odkaz:
https://doaj.org/article/c637d11be435406898ecf3fc34ead099
Autor:
Scott Frendo-Cumbo, Taoyingnan Li, Dustin A. Ammendolia, Etienne Coyaud, Estelle M.N. Laurent, Yuan Liu, Philip J. Bilan, Gordon Polevoy, Brian Raught, Julie A. Brill, Amira Klip, John H. Brumell
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105188- (2022)
Summary: Cell proliferation is dependent on growth factors insulin and IGF1. We sought to identify interactors of IRS1, the most proximal mediator of insulin/IGF1 signaling, that regulate cell proliferation. Using proximity-dependent biotin identific
Externí odkaz:
https://doaj.org/article/ac64290d00ae465c951ce30b06a4ac90
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-29 (2021)
Abstract Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment. To avoid lethal consequences, cells are equipped wi
Externí odkaz:
https://doaj.org/article/7a5b2f85a4134f3f8a10a03f3c5852a3
Autor:
Evan Amalfitano, Margot Karlikow, Masoud Norouzi, Katariina Jaenes, Seray Cicek, Fahim Masum, Peivand Sadat Mousavi, Yuxiu Guo, Laura Tang, Andrew Sydor, Duo Ma, Joel D. Pearson, Daniel Trcka, Mathieu Pinette, Aruna Ambagala, Shawn Babiuk, Bradley Pickering, Jeff Wrana, Rod Bremner, Tony Mazzulli, David Sinton, John H. Brumell, Alexander A. Green, Keith Pardee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Getting synthetic biology circuit-based sensors into field applications is still a challenge. Here the authors combine a circuit sensor with a glucose meter for small analyte and nucleic acid detection.
Externí odkaz:
https://doaj.org/article/3cb9f77bab4e4f33b765a22e58579292
Autor:
Angela Zou, Kerry Nadeau, Pauline W. Wang, Jee Yeon Lee, David S. Guttman, Shayan Sharif, Doug R. Korver, John H. Brumell, John Parkinson
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background To satisfy an increasing demand for dietary protein, the poultry industry has employed genetic selection to increase the growth rate of broilers by over 400% in the past 50 years. Although modern broilers reach a marketable weight
Externí odkaz:
https://doaj.org/article/2bd5eb8f1a5d49b0926c9ec7036b3306
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Insulin is a paramount anabolic hormone that promotes energy-storage in adipose tissue, skeletal muscle and liver, and these responses are significantly attenuated in insulin resistance leading to type 2 diabetes. Contrasting with insulin’s functio
Externí odkaz:
https://doaj.org/article/110d5782767f4a928f4e6bd60dd32296
Autor:
Andrew Wang, Luciene R. Carraro-Lacroix, Celeste Owen, Bowen Gao, Paul N. Corey, Pascal Tyrrell, John H. Brumell, Irina Voronov
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Mammalian target of rapamycin (mTOR) is activated by numerous stimuli, including amino acids and growth factors. This kinase is part of the mTOR complex 1 (mTORC1) which regulates cell proliferation, differentiation, and autophagy. Active mT
Externí odkaz:
https://doaj.org/article/48c316c68a3b41edb20300c3142b91c4