Zobrazeno 1 - 10
of 554
pro vyhledávání: '"John H, Griffin"'
Autor:
Shivani Bansal, Yaoxiang Li, Sunil Bansal, William Klotzbier, Baldev Singh, Meth Jayatilake, Vijayalakshmi Sridharan, José A. Fernández, John H. Griffin, Hartmut Weiler, Marjan Boerma, Amrita K. Cheema
Publikováno v:
Metabolites, Vol 14, Iss 5, p 245 (2024)
Exposure to ionizing radiation, accidental or intentional, may lead to delayed effects of acute radiation exposure (DEARE) that manifest as injury to organ systems, including the kidney, heart, and brain. This study examines the role of activated pro
Externí odkaz:
https://doaj.org/article/42a2683e6be948beab598818f29e7231
Autor:
Moh’d Mohanad Al-Dabet, Khurrum Shahzad, Ahmed Elwakiel, Alba Sulaj, Stefan Kopf, Fabian Bock, Ihsan Gadi, Silke Zimmermann, Rajiv Rana, Shruthi Krishnan, Dheerendra Gupta, Jayakumar Manoharan, Sameen Fatima, Sumra Nazir, Constantin Schwab, Ronny Baber, Markus Scholz, Robert Geffers, Peter Rene Mertens, Peter P. Nawroth, John H. Griffin, Maria Keller, Chris Dockendorff, Shrey Kohli, Berend Isermann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyp
Externí odkaz:
https://doaj.org/article/e0c24968fbe44886ac4eb5d91d955ed8
Autor:
Charles P. Hinzman, Meth Jayatilake, Sunil Bansal, Brian L. Fish, Yaoxiang Li, Yubo Zhang, Shivani Bansal, Michael Girgis, Anton Iliuk, Xiao Xu, Jose A. Fernandez, John H. Griffin, Elizabeth A. Ballew, Keith Unger, Marjan Boerma, Meetha Medhora, Amrita K. Cheema
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Urinary extracellular vesicles (EVs) are a source of biomarkers with broad potential applications across clinical research, including monitoring radiation exposure. A key limitation to their implementation is minimal standardizati
Externí odkaz:
https://doaj.org/article/c5426affb3a14b0b9aa3b0ca913f86c2
Autor:
Magdalena L. Bochenek, Rajinikanth Gogiraju, Stefanie Großmann, Janina Krug, Jennifer Orth, Sabine Reyda, George S. Georgiadis, Henri M. Spronk, Stavros Konstantinides, Thomas Münzel, John H. Griffin, Philipp Wild, Christine Espinola-Klein, Wolfram Ruf, Katrin Schäfer
Publikováno v:
JCI Insight, Vol 7, Iss 14 (2022)
Blood clot formation initiates ischemic events, but coagulation roles during postischemic tissue repair are poorly understood. The endothelial protein C receptor (EPCR) regulates coagulation, as well as immune and vascular signaling, by protease acti
Externí odkaz:
https://doaj.org/article/0909dcd5f8c44e619cf8af8d0733a288
Autor:
Yaoxiang Li, Shivani Bansal, Vijayalakshmi Sridharan, Sunil Bansal, Meth M. Jayatilake, Jose A. Fernández, John H. Griffin, Marjan Boerma, Amrita K. Cheema
Publikováno v:
Metabolites, Vol 13, Iss 4, p 525 (2023)
Survivors of acute radiation exposure are likely to experience delayed effects that manifest as injury in late-responding organs such as the heart. Non-invasive indicators of radiation-induced cardiac dysfunction are important in the prediction and d
Externí odkaz:
https://doaj.org/article/7a8a37e081d041f4a59e039b659f40d1
COVID‐19 hypothesis: Activated protein C for therapy of virus‐induced pathologic thromboinflammation
Autor:
John H. Griffin, Patrick Lyden
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 4, Pp 506-509 (2020)
Abstract Seriously ill patients with coronavirus disease 2019 (COVID‐19) at risk for death exhibit elevated cytokine and chemokine levels and D‐dimer, and they often have comorbidities related to vascular dysfunctions. In preclinical studies, act
Externí odkaz:
https://doaj.org/article/68fd5eb7ec7b4089a4f0d4972d8d0195
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 2, Pp 217-223 (2020)
Abstract Background Serum amyloid A4 (SAA4) is an apolipoprotein that is in the SAA family and it is constitutively translated. Previously, acute‐phase SAA1 and SAA2 levels were associated with venous thromboembolism (VTE). Objective We investigate
Externí odkaz:
https://doaj.org/article/d7ed9394b3824e97868e63e756812a35
Autor:
Yaoming Wang, Kassandra Kisler, Angeliki Maria Nikolakopoulou, Jose A. Fernandez, John H. Griffin, Berislav V. Zlokovic
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Pericytes, mural cells of brain capillaries, maintain the blood-brain barrier (BBB), regulate cerebral blood flow (CBF), and protect neurons against ischemic damage. To further investigate the role of pericytes in ischemia, we induced stroke by 45-mi
Externí odkaz:
https://doaj.org/article/fee37c5c24b34d5b86b090f53605b805
Autor:
Patrick D. Lyden, Kent E. Pryor, Jennifer Minigh, Thomas P. Davis, John H. Griffin, Howard Levy, Berislav V. Zlokovic
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Ischemic stroke is the most widespread cause of disability and a leading cause of death in developed countries. To date, the most potent approved treatment for acute stroke is recanalization therapy with thrombolytic drugs such as tissue plasminogen
Externí odkaz:
https://doaj.org/article/9a1715fe40b4444697df6d9a142ca50f
Autor:
Vijayalakshmi Sridharan, Kristin A Johnson, Reid D Landes, Maohua Cao, Preeti Singh, Gail Wagoner, Abdallah Hayar, Emily D Sprick, Kayla A Eveld, Anusha Bhattacharyya, Kimberly J Krager, Nukhet Aykin-Burns, Hartmut Weiler, Jose A Fernández, John H Griffin, Marjan Boerma
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0252142 (2021)
Accidental exposure to ionizing radiation may lead to delayed effects of acute radiation exposure (DEARE) in many organ systems. Activated protein C (APC) is a known mitigator of the acute radiation syndrome. To examine the role of APC in DEARE, we u
Externí odkaz:
https://doaj.org/article/50e75a3eea9247aa991916479ae21a30