Reserve stem cell population in intestinal crypts found to be consistently small by analysis of in vivo clonogenic assays with a biomathematical dynamic model

Autor: Emanuel Bahn, W. Shaw, Jacobus P. Slabbert, John Gueulette, Jürgen Debus, Michelle van Heerden, Markus Alber

Publikováno v: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 129(3)

Background and purpose The high plasticity of the intestinal epithelium is maintained by a resilient reserve stem cell population, whose extent and biology are a matter of ongoing debate. The in vivo clonogenic assay (IVCA), presents a well establish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfdf4167cee7918193c1dd19f89d841
https://pubmed.ncbi.nlm.nih.gov/30100258

Combination of the mTOR inhibitor RAD001 with temozolomide and radiation effectively inhibits the growth of glioblastoma cells in culture

Autor: Pierre Bischoff, Hélène Burckel, Georges Noël, Jean-Marc Denis, John Gueulette, Jakobus Slabbert, Elodie Josset

Publikováno v: Oncology Reports. 33:471-477

The present in vitro study aimed to assess the effects of combining the mTOR inhibitor RAD001 and temozolomide (TMZ) together with irradiation by either low-linear energy transfer (LET) radiation (γ-rays) or high-LET radiation (fast neutrons) on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fa64f6da7e87196c2378e805fb454a
https://doi.org/10.3892/or.2014.3590

Different dose rate-dependent responses of human melanoma cells and fibroblasts to low dose fast neutrons

Autor: Emmanuel Chautard, Claude Dionet, Pierre Verrelle, Dietrich Averbeck, Bruno Pereira, Geoffroy Marceau, Mélanie Müller-Barthélémy, Andrei Tchirkov, John Gueulette, Jean-Marc Denis, Vincent Sapin

Publikováno v: International Journal of Radiation Biology
International Journal of Radiation Biology, 2016, 92 (9), pp.527-35. ⟨10.1080/09553002.2016.1186300⟩
International Journal of Radiation Biology, Informa Healthcare, 2016, 92 (9), pp.527-35. ⟨10.1080/09553002.2016.1186300⟩

International audience; Purpose: To analyze the dose rate influence in hyper-radiosensitivity (HRS) of human melanoma cells to very low doses of fast neutrons and to compare to the behaviour of normal human skin fibroblasts.Materials and methods: We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7988be5778fc23d30aa894df5c007c73
https://pubmed.ncbi.nlm.nih.gov/27258624

What can we learn from the neutron clinical experience for improving ion-beam techniques and high-LET patient selection?

Autor: R. Gahbauer, D. T. L. Jones, John Gueulette, André Wambersie, Paul M. DeLuca

Publikováno v: Radiation Measurements. 45:1374-1380

Historically, improvements in radiotherapy have been mainly due to improvements in physical selectivity: beam penetration, collimation, dosimetry, treatment planning; and advances in imaging. Neutrons were the first high-LET (linear energy transfer)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a873d66fa96dc68262f4caf9118d45d2
https://doi.org/10.1016/j.radmeas.2010.04.013

Cell death induced in a human glioblastoma cell line by p(65)+Be neutrons combined with cisplatin

Autor: Patrick Dufour, John Gueulette, Anne Miternique-Grosse, Jean-Marc Denis, Sami Benzina, Pierre Bischoff, Barbara Fischer, Jean-Pierre Bergerat

Publikováno v: Life Sciences. 79:513-518

High linear energy transfer (LET) radiation have the ability to kill cancer cells resistant to conventional radiotherapy. On the other hand, protocols combining radiotherapy and chemotherapy are effective in eradicating certain inoperable cancers. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf1023837df4acc5410ae4182d53ccd
https://doi.org/10.1016/j.lfs.2006.01.037