Zobrazeno 1 - 10
of 29
pro vyhledávání: '"John Greally"'
Autor:
Kristen M. Wigby, Deanna Brockman, Gregory Costain, Caitlin Hale, Stacie L. Taylor, John Belmont, David Bick, David Dimmock, Susan Fernbach, John Greally, Vaidehi Jobanputra, Shashikant Kulkarni, Elizabeth Spiteri, Ryan J. Taft
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Early use of genome sequencing (GS) in the diagnostic odyssey can reduce suffering and improve care, but questions remain about which patient populations are most amenable to GS as a first-line diagnostic test. To address this, the Medical G
Externí odkaz:
https://doaj.org/article/27365d57311546bc828aa98a13d450ea
Autor:
Elina Jerschow, MD, MSc, Robert Dubin, PhD, Chien-Chang Chen, PhD, Alex iAkushev, MSc, Esha Sehanobish, PhD, Mohammad Asad, PhD, Sergio E. Chiarella, MD, Steven A. Porcelli, MD, John Greally, DMed, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 2, Pp 100205- (2024)
Background: Previous studies have determined that up to 6% of patients with aspirin-exacerbated respiratory disease (AERD) have family history of AERD, indicating a possible link with genetic polymorphisms. However, whole exome sequencing (WES) studi
Externí odkaz:
https://doaj.org/article/58777f142b2e4073be348c78a925fd85
Autor:
Priya Marathe, Sabrina Suckiel, Jacqueline Odgis, Katie Gallagher, Monisha Sebastin, Katherine Bonini, Kaitlyn Brown, Miranda Di Biase, Nicole Kelly, Michelle Ramos, Jessica Rodriguez, Laura Scarimbolo, Beverly Insel, Randi Zinberg, George Diaz, John Greally, Noura Abul-Husn, Laurie Bauman, Carol Horowitz, Bruce Gelb, Melissa Wasserstein, Eimear Kenny
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100273- (2023)
Externí odkaz:
https://doaj.org/article/e6a6c63c6bd449fe845803a2919a4d12
Autor:
Sabrina Suckiel, Nicole Kelly, Jacqueline Odgis, Katie Gallagher, Monisha Sebastin, Katherine Bonini, Priya Marathe, Kaitlyn Brown, Miranda Di Biase, Michelle Ramos, Jessica Rodriguez, Laura Scarimbolo, Beverly Insel, Randi Zinberg, George Diaz, John Greally, Noura Abul-Husn, Laurie Bauman, Carol Horowitz, Bruce Gelb, Melissa Wasserstein, Eimear Kenny
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100346- (2023)
Externí odkaz:
https://doaj.org/article/46cc9a0b6de5432f8488a2548e68a0b2
Autor:
Yu Kong, Christopher M. Rose, Ashley A. Cass, Alexander G. Williams, Martine Darwish, Steve Lianoglou, Peter M. Haverty, Ann-Jay Tong, Craig Blanchette, Matthew L. Albert, Ira Mellman, Richard Bourgon, John Greally, Suchit Jhunjhunwala, Haiyin Chen-Harris
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.
Externí odkaz:
https://doaj.org/article/4f372d927b9744d19d8bbddc89834da4
Autor:
Alexandre Pelletier, Arnaud Carrier, Yongmei Zhao, Mickaël Canouil, Mehdi Derhourhi, Emmanuelle Durand, Lionel Berberian-Ferrato, John Greally, Francine Hughes, Philippe Froguel, Amélie Bonnefond, Fabien Delahaye
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7323 (2022)
Excessive fetal growth is associated with DNA methylation alterations in human hematopoietic stem and progenitor cells (HSPC), but their functional impact remains elusive. We implemented an integrative analysis combining single-cell epigenomics, sing
Externí odkaz:
https://doaj.org/article/a2b06bb457d84a89a152df63f1a64cf1
Publikováno v:
Bio-Protocol, Vol 10, Iss 17 (2020)
Dynamic histone changes occur as a central part of chromatin regulation. Deposition of histone variants and post-translational modifications of histones are strongly associated with properties of chromatin status. Characterizing the kinetics of histo
Externí odkaz:
https://doaj.org/article/be763e2a47e24d2abeeb25952dda8fb7
Autor:
Tushar D Bhagat, Dagny Von Ahrens, Meelad Dawlaty, Yiyu Zou, Joelle Baddour, Abhinav Achreja, Hongyun Zhao, Lifeng Yang, Brijesh Patel, Changsoo Kwak, Gaurav S Choudhary, Shanisha Gordon-Mitchell, Srinivas Aluri, Sanchari Bhattacharyya, Srabani Sahu, Prafulla Bhagat, Yiting Yu, Matthias Bartenstein, Orsi Giricz, Masako Suzuki, Davendra Sohal, Sonal Gupta, Paola A Guerrero, Surinder Batra, Michael Goggins, Ulrich Steidl, John Greally, Beamon Agarwal, Kith Pradhan, Debabrata Banerjee, Deepak Nagrath, Anirban Maitra, Amit Verma
Publikováno v:
eLife, Vol 8 (2019)
Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are not well elucidated. An epigenomic analysis of patient-derived and de-
Externí odkaz:
https://doaj.org/article/de3a332d705e4701ab12d60c3c437380
Autor:
Davendra Sohal, Andrew Yeatts, Kenny Ye, Andrea Pellagatti, Li Zhou, Perry Pahanish, Yongkai Mo, Tushar Bhagat, John Mariadason, Jacqueline Boultwood, Ari Melnick, John Greally, Amit Verma
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2965 (2008)
Microarray-based studies of global gene expression (GE) have resulted in a large amount of data that can be mined for further insights into disease and physiology. Meta-analysis of these data is hampered by technical limitations due to many different
Externí odkaz:
https://doaj.org/article/c5be5fcfd2fa4a61954a741ff8fc649c
Autor:
John Greally, Taylor Thompson
Environmental obesogens are being studied for their potential role in the increasing prevalence of obesity globally. A major focus in this field of research has been on the mechanism by which these agents act. In this study we focused on the obesogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::340f2e6805c85487dc7762f9c82c99b9
https://doi.org/10.1101/2022.06.28.497908
https://doi.org/10.1101/2022.06.28.497908