Zobrazeno 1 - 10
of 21
pro vyhledávání: '"John Goldsworthy"'
Autor:
Stephen John Goldsworthy
Describes the activities of stunt men and women, their various stunts in and out of the movies, safety precautions, and famous stunt people.
Publikováno v:
Journal of Neurochemistry. 63:769-772
Metabotropic glutamate receptors (mGluRs) are a heterogeneous family of G protein-coupled glutamate receptors that are linked to multiple second messenger systems in the CNS. In this study the selectivity of mGluR agonists for different mGluR second
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa1212cbbf5ca591231fdd01e88c593
https://doi.org/10.1046/j.1471-4159.1994.63020769.x
https://doi.org/10.1046/j.1471-4159.1994.63020769.x
Autor:
Ivan Collado, B. A. Ballyk, Concepción Pedregal, Jesus Ezquerra, Ken Hoo, David Bleakman, Ana I. Mateo, Carmen Dominguez, John Goldsworthy, Stephen Richard Baker, Ana Maria Escribano, Almudena Rubio, Rajender K. Kamboj
Publikováno v:
Journal of Medicinal Chemistry. 43:1958-1968
Enantiomerically pure (2S,4R)-4-substituted glutamic acids were prepared and tested for homomeric GluR5 and GluR6 kainate subtype receptor affinity. Some of the 4-cinnamyl analogues showed high selectivity and potency (K(i)25 nM) for the GluR5 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e24a09d3841e85a888cb34b4a431c42
https://doi.org/10.1021/jm9911682
https://doi.org/10.1021/jm9911682
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2777-2780
The synthesis of three novel 4-carboxyphenylglycine derivatives is described. 2-Methyl substituents increase the antagonist potency compared to (S)-4CPG at mGluR1 receptors. Resolution of compound 1 showed that the activity resided in the (+)-isomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e671fe2237b6a0ce7e0dcacc654ed62
https://doi.org/10.1016/s0960-894x(97)10071-3
https://doi.org/10.1016/s0960-894x(97)10071-3
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:223-228
3,5-Dihydroxyphenylglycine (3,5-DHPG) was resolved using an aminoacylase enzyme in solution, and the enantiomers characterised for ability to stimulate metabotropic glutamate receptor (mGluR) mediated phosphoinositide hydrolysis in rat hippocampus. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13dc7e5613604476df5fda0347026e32
https://doi.org/10.1016/0960-894x(95)00013-j
https://doi.org/10.1016/0960-894x(95)00013-j
Autor:
John Goldsworthy, S. Richard Baker
Publikováno v:
Synthetic Communications. 24:1947-1957
The synthesis of biphenyl amino acids, designed as potential metabotropic glutamate receptor ligands, is described. Some unexpected tricyclic intermediates were characterised and one such intermediate was further transformed into the related 2,3-dihy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4ed6f109b770e4f1e3874976402f5ea
https://doi.org/10.1080/00397919408010202
https://doi.org/10.1080/00397919408010202
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::781d27f8b2a280d8721209d073e25d38
https://doi.org/10.1002/chin.199527246
https://doi.org/10.1002/chin.199527246
Autor:
Ann E. Kingston, John Goldsworthy, Stephen Richard Baker, Barry Peter Clark, John Richard Harris
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325a787ec9a1a522ac7500f48da8bf1c
https://doi.org/10.1002/chin.199811218
https://doi.org/10.1002/chin.199811218
Autor:
Rebecca A. Wright, Darryle D. Schoepp, John Goldsworthy, S. Richard Baker, Craig R. Salhoff, Bryan G. Johnson
Publikováno v:
Journal of neuroscience methods. 59(1)
G-Protein-coupled or ‘metabotropic’ glutamate receptors (mGluRs) are a novel heterogenous family of excitatory amino acid receptors. Activation of mGluRs in the rat hippocampus by the mGluR-selective agonist 1 S ,3 R -1-aminocyclopentane-1,3-dica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19230a155a316ebadd1686bf5630067f
https://pubmed.ncbi.nlm.nih.gov/7475239
https://pubmed.ncbi.nlm.nih.gov/7475239
Autor:
S. Richard Baker, John Goldsworthy, Will G. Prowse, Stéphane Borrelly, Ann E. Kingston, Darryle D. Schoepp
Publikováno v:
Neuropharmacology. 35:A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6114dc66b72e4fe32ba8e18888e574db
https://doi.org/10.1016/0028-3908(96)84650-8
https://doi.org/10.1016/0028-3908(96)84650-8