Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease

Autor: Robin Verhaar, Benjamin Drukarch, John G.J.M. Bol, Cornelis A.M. Jongenelen, René J.P. Musters, Micha M.M. Wilhelmus

Publikováno v: Neurobiology of Disease, Vol 45, Iss 3, Pp 839-850 (2012)

Parkinson's disease (PD) is characterized by accumulation of α-synuclein aggregates and degeneration of melanized, catecholaminergic neurons. The tissue transglutaminase (tTG) enzyme catalyzes molecular protein cross-linking. In PD, tTG levels are i

Externí odkaz: https://doaj.org/article/0cd4b15073ca419cbb57cf9a598aba4d

Myelin quantification in white matter pathology of progressive multiple sclerosis post-mortem brain samples:A new approach for quantifying remyelination

Autor: John G.J.M. Bol, Jeroen J. G. Geurts, Marije J. D. Huitema, Eva M.M. Strijbis, Geert J. Schenk, Antonio Luchicchi, Jason R. Plemel

Publikováno v: Huitema, M J D, Strijbis, E M M, Luchicchi, A, Bol, J G J M, Plemel, J R, Geurts, J J G & Schenk, G J 2021, ' Myelin quantification in white matter pathology of progressive multiple sclerosis post-mortem brain samples : A new approach for quantifying remyelination ', International Journal of Molecular Sciences, vol. 22, no. 23, 12634 . https://doi.org/10.3390/ijms222312634
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12634
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 22(23):12634. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 22, Iss 12634, p 12634 (2021)

Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS). Repair through remyelination can be extensive, but quantification of remyelination remains challenging. To date, no method for standardized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f5ea43c64e10a8f620cdca55906269
https://research.vumc.nl/en/publications/5e6c4225-98c0-4cd4-819d-0d952ce08b5d

Amyloid-β, p-tau and reactive microglia are pathological correlates of MRI cortical atrophy in Alzheimer's disease

Autor: Frederik Barkhof, Jeroen J. M. Hoozemans, Laura E. Jonkman, Annemieke J.M. Rozemuller, John G.J.M. Bol, Baayla D.C. Boon, Chen-Pei Lin, Irene Frigerio, Jos W. R. Twisk, Yvon Galis-de Graaf, Femke H. Bouwman, Paolo Preziosa, Wilma D.J. van de Berg

Publikováno v: Brain Communications, 3(4):fcab281. Oxford University Press
Frigerio, I, Boon, B D C, Lin, C-P, Graaf, Y G-D, Bol, J, Preziosa, P, Twisk, J, Barkhof, F, Hoozemans, J J M, Bouwman, F H, Rozemuller, A J M, van de Berg, W D J & Jonkman, L E 2021, ' Amyloid-β, p-tau and reactive microglia are pathological correlates of MRI cortical atrophy in Alzheimer's disease ', Brain Communications, vol. 3, no. 4, fcab281 . https://doi.org/10.1093/braincomms/fcab281
Brain Communications

Alzheimer’s disease is characterized by cortical atrophy on MRI and abnormal depositions of amyloid-beta, phosphorylated-tau and inflammation pathologically. However, the relative contribution of these pathological hallmarks to cortical atrophy, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa96e9e7f3dae45998d684c3acfb2ca
https://research.vumc.nl/en/publications/0cbd5f74-aa28-4f4b-ba66-24b2726ce4c0

Monocyte behaviour and tissue transglutaminase expression during experimental autoimmune encephalomyelitis in transgenic CX3CR1gfp/gfp mice

Autor: Benjamin Drukarch, Alexandre Jaouen, Franck Debarbieux, Micha M.M. Wilhelmus, Keith K. Fenrich, John G.J.M. Bol, Navina L. Chrobok, Anne Marie Van Dam

Publikováno v: Amino Acids
Chrobok, N L, Jaouen, A, Fenrich, K K, Bol, J G J M, Wilhelmus, M M M, Drukarch, B, Debarbieux, F & van Dam, A M 2017, ' Monocyte behaviour and tissue transglutaminase expression during experimental autoimmune encephalomyelitis in transgenic CX3CR1 gfp/gfp mice ', Amino Acids, vol. 49, no. 3, pp. 643-658 . https://doi.org/10.1007/s00726-016-2359-0
Amino Acids, 49(3), 643-658. Springer Wien

Leukocyte infiltration into the central nervous system (CNS) is a key pathological feature in multiple sclerosis (MS) and the MS animal model experimental autoimmune encephalomyelitis (EAE). Recently, preventing leukocyte influx into the CNS of MS pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a985f733eb79c18fd501061de7b948c3
http://www.scopus.com/inward/record.url?scp=84994468999&partnerID=8YFLogxK

Enhanced GABAergic Immunoreactivity in Hippocampal Neurons and Astroglia of Multiple Sclerosis Patients

Autor: M. Prins, Geert J. Schenk, Anne Marie van Dam, John G.J.M. Bol, Bart M. L. Baselmans, Svenja Kiljan

Publikováno v: Journal of Neuropathology and Experimental Neurology
Kiljan, S, Prins, M, Baselmans, B M, Bol, J G J M, Schenk, G J & van Dam, A M 2019, ' Enhanced GABAergic Immunoreactivity in Hippocampal Neurons and Astroglia of Multiple Sclerosis Patients ', Journal of neuropathology and experimental neurology, vol. 78, no. 6, pp. 480-491 . https://doi.org/10.1093/jnen/nlz028
Kiljan, S, Prins, M, Baselmans, B M, Bol, J G J M, Schenk, G J & van Dam, A-M 2019, ' Enhanced GABAergic immunoreactivity in hippocampal neurons and astroglia of multiple sclerosis patients ', Journal of Neuropathology and Experimental Neurology, vol. 78, no. 6, pp. 480-491 . https://doi.org/10.1093/jnen/nlz028
Journal of Neuropathology and Experimental Neurology, 78(6), 480-491. Lippincott Williams and Wilkins
Journal of neuropathology and experimental neurology, 78(6), 480-491. OUP

Cognitive dysfunction occurs frequently in multiple sclerosis (MS). Research suggests that hippocampal lesions and GABAergic neurotransmitter changes contribute to cognitive dysfunction. In the present study, we aim to determine the cellular changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821a9639384c1883c51461a6d3ce7557
https://pubmed.ncbi.nlm.nih.gov/31100147