Zobrazeno 1 - 10
of 83
pro vyhledávání: '"John G. Wise"'
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250371 (2021)
P-glycoprotein (P-gp) is a critical membrane transporter in the blood brain barrier (BBB) and is implicated in Alzheimer's disease (AD). However, previous studies on the ability of P-gp to directly transport the Alzheimer's associated amyloid-β (Aβ
Externí odkaz:
https://doaj.org/article/d65591ac78d74ab7b49b37ad26f7cea9
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217940 (2019)
One common reason for cancer chemotherapy failure is increased drug efflux catalyzed by membrane transporters with broad pump substrate specificities, which leads to resistances to a wide range of chemically unrelated drugs. This multidrug resistance
Externí odkaz:
https://doaj.org/article/85d7256a0d574f3583a1a41897f6c7fd
Publikováno v:
Biochemistry. 60:3098-3113
Antibiotic-resistant gonorrheal infections are an urgent health concern. The MtrCDE system confers multidrug resistance to Neisseria gonorrhoeae, an obligate human pathogen, and the causative agent of the sexually-transmitted infection gonorrhea. The
Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches
Autor:
Maha Aljowni, Pia D. Vogel, Gang Chen, John G. Wise, Amila K. Nanayakkara, Maisa C. Oliveira, Ketetha Olengue, Alexander R. Lippert, Lauren Ammerman
Publikováno v:
J Med Chem
Overexpression of ABC transporters like P-glycoprotein (P-gp) has been correlated with resistances in cancer chemotherapy. Intensive efforts to identify P-gp inhibitors for use in combination therapy have not led to clinically approved inhibitors to
Autor:
Alexander R. Lippert, John G. Wise, Maha Aljowni, Kasi L. Holcomb-Webb, Pia D. Vogel, Amila K. Nanayakkara
Publikováno v:
The FASEB Journal. 33
Autor:
Pia D. Vogel, John G. Wise, Jennifer M. Edgar, Madeline K. Jensen, Maisa C. Olivera, Roxana Farokhnia, Dakota D. D. Okwuone
Publikováno v:
The FASEB Journal. 33
Autor:
John G. Wise, Maisa C. Oliveira, Roxana Farokhnia, Pia D. Vogel, Madeline K. Jensen, Jennifer M. Edgar, Dakota D. D. Okwuone
Publikováno v:
The FASEB Journal. 33
Autor:
Pia D. Vogel, Collette A. Lavigne, Dakota D. D. Okwuone, John G. Wise, Roxana Farokhnia, Jennifer M. Edgar, Maisa C. Oliveira, Madeline K. Jensen
Publikováno v:
The FASEB Journal. 33
Autor:
John G. Wise, Madeline K. Jensen, Maisa C. Oliveira, Dakota D. D. Okwuone, Pia D. Vogel, Roxana Farokhnia, Jennifer M. Edgar
Publikováno v:
The FASEB Journal. 33
P-glycoprotein (P-gp) overexpression is often correlated with multidrug-resistance (MDR) of cancer. To search for P-gp inhibitors as co-therapeutics to combat MDR, we had previously used high-throu...
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250371 (2021)
PLoS ONE
PLoS ONE
P-glycoprotein (P-gp) is a critical membrane transporter in the blood brain barrier (BBB) and is implicated in Alzheimer’s disease (AD). However, previous studies on the ability of P-gp to directly transport the Alzheimer’s associated amyloid-β