Zobrazeno 1 - 10
of 37
pro vyhledávání: '"John G. Shelton"'
Autor:
Ferdinando Nicoletti, James A. McCubrey, John G. Shelton, Jörg Bäsecke, Alberto M. Martelli, Stephen L. Abrams, Linda S. Steelman, William H. Chappell, Massimo Libra, Ellis W.T. Wong, Marco Donia, Franca Stivala
Publikováno v:
Cell Cycle. 9:1781-1791
The effects of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways on proliferation, drug resistance, prevention of apoptosis and sensitivity to signal transduction inhibitors were examined in FL/DeltaAkt-1:ER*(Myr(+)) + DeltaRaf-1:AR cells whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94e1ec5539a00bfc80588ec68fc6cf6
https://doi.org/10.4161/cc.9.9.11483
https://doi.org/10.4161/cc.9.9.11483
Autor:
Linda S. Steelman, Fred E. Bertrand, Edmond R. White, Dale L. Ludwig, William H. Chappell, John G. Shelton, Steve L. Abrams, James A. McCubrey
Publikováno v:
Leukemia. 20:1254-1260
The Insulin-like growth factor-1 receptor (IGF-1R) is overexpressed in a variety of tumors including breast, prostate and myeloma. Thus, IGF-1R and its downstream signaling effectors are good candidates for molecular-based targeted antitumor therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658b4d7e6f2d49bb46ee7e11dea1431f
https://doi.org/10.1038/sj.leu.2404217
https://doi.org/10.1038/sj.leu.2404217
Autor:
Richard A. Franklin, Shaw M. Akula, John G. Shelton, Linda S. Steelman, Fred E. Bertrand, Martin McMahon, James A. McCubrey, Steven L. Abrams, Edmund R. White
Publikováno v:
Cell Cycle. 4:822-830
v-ErbB is an oncogene related to the Epidermal Growth Factor Receptor (EGFR). EGFR overexpression has been observed in many pathological situations. There is a truncated form of EGFR, referred to as EGFvIII, which resembles v-ErbB in biological prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dce6f1ecefc3dbfe502e91888899870
https://doi.org/10.4161/cc.4.6.1724
https://doi.org/10.4161/cc.4.6.1724
Autor:
Richard A. Franklin, John G. Shelton, James A. McCubrey, Linda S. Steelman, Edmund R. White, Fred E. Bertrand, Shaw M. Akula, Steven L. Abrams
Publikováno v:
Cell Cycle. 4:818-821
Epidermal growth factor (EGF) is commonly thought to affect the proliferation of many cells, especially epithelial cells. Aberrant expression of the receptor for EGF, (EGFR) or members of the EGFR family is often implicated in the etiology of many ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fb507f45887aae44526b6e4677252a
https://doi.org/10.4161/cc.4.6.1723
https://doi.org/10.4161/cc.4.6.1723
Publikováno v:
Infection and Immunity. 73:878-882
Pseudomonas aeruginosa is a gram-negative bacterium that causes serious infections in immunocompromised individuals and cystic fibrosis patients. This opportunistic pathogen controls many of its virulence factors and cellular functions through the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3ec7f5104ff3e6688488930758d0b4
https://doi.org/10.1128/iai.73.2.878-882.2005
https://doi.org/10.1128/iai.73.2.878-882.2005
Publikováno v:
Leukemia. 19:98-102
Bone marrow stromal cells are essential for the differentiation, survival and proliferation of normal and leukemic human B-lineage cells. Leukemic cells require stromal cell support for optimal proliferation and apoptotic resistance. Stromal cell con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c32c4721169c7985dc861e8932c23c
https://doi.org/10.1038/sj.leu.2403560
https://doi.org/10.1038/sj.leu.2403560
Autor:
James A. McCubrey, Linda S. Steelman, Martin McMahon, Thazepadath Sreevalsan, John G. Shelton, Richard A. Franklin
Publikováno v:
Oncogene. 23:7810-7820
Epidermal growth factor (EGF) and its cognate receptor (EGF-R) are often dysregulated in human neoplasia. Moreover, EGF-R-transformed cell lines have constitutive EGF-R activity, which makes elucidation of its effects difficult to determine. In the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5dbcc7b3acc90741074721fa14d1d4
https://doi.org/10.1038/sj.onc.1208055
https://doi.org/10.1038/sj.onc.1208055
Publikováno v:
Cell Cycle. 3:370-377
The insulin like growth factor-1 (IGF-1) receptor (R) induced PI3K/Akt signal transduction cascade has critical roles in prevention of apoptosis and regulation of cell cycle progression. Here, we discuss the effects of IGF-1R-mediated signal transduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b63e78d7e7382ae546235acd9c461c0
https://doi.org/10.4161/cc.3.3.747
https://doi.org/10.4161/cc.3.3.747
Autor:
John T. Lee, Fumin Chang, James A. McCubrey, Richard A. Franklin, Linda S. Steelman, John G. Shelton
Publikováno v:
Cell Cycle. 3:184-191
FDC-P1 hematopoietic cells were conditionally transformed to grow in response to ΔB-Raf:ER, ΔRaf-1:ER or ΔA-Raf:ER in which the hormone binding domain of the estrogen receptor (ER) was linked to the N-terminal truncated (Δ) Raf genes. When these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3b2ac942a8a7e4554161a8b468b781a
https://doi.org/10.4161/cc.3.2.624
https://doi.org/10.4161/cc.3.2.624
Autor:
John G. Shelton, Richard A. Franklin, James A. McCubrey, Steven C. Pohnert, Linda S. Steelman, Fred E. Bertrand
Publikováno v:
Leukemia. 18:189-218
The roles of the JAK/STAT, Raf/MEK/ERK and PI3K/Akt signal transduction pathways and the BCR-ABL oncoprotein in leukemogenesis and their importance in the regulation of cell cycle progression and apoptosis are discussed in this review. These pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156ca32617a0052b8745002d65cf1502
https://doi.org/10.1038/sj.leu.2403241
https://doi.org/10.1038/sj.leu.2403241