Zobrazeno 1 - 10
of 42
pro vyhledávání: '"John G. Pastorino"'
Autor:
Nataly Shulga, John G. Pastorino
Publikováno v:
Biology Open, Vol 5, Iss 7, Pp 1010-1010 (2016)
Externí odkaz:
https://doaj.org/article/a29ba768c2a94e66ad6cab357ded975d
Autor:
Nataly Shulga, John G. Pastorino
Publikováno v:
Journal of Biological Chemistry. 289:26213-26226
Ethanol exposure promotes the development of steatohepatitis, which can progress to end stage liver disease. Kupffer cells have been documented to play a key role in the genesis and progression of alcoholic liver disease with ethanol exposure enhanci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1dc8c67786bb8fa817255afddff4e0
https://doi.org/10.1074/jbc.m114.580175
https://doi.org/10.1074/jbc.m114.580175
Autor:
Catherine Neary, John G. Pastorino
Publikováno v:
Journal of Cellular Physiology. 228:1943-1948
Hexokinase II (HK2), the enzyme that catalyzes the first committed step of glycolysis, is overexpressed in many cancers, as is the central signaling kinase Akt. Akt activity promotes HK2 association with the mitochondria, as well as glucose uptake by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951cbdbf515bdb57a8ffcba7dd8a8523
https://doi.org/10.1002/jcp.24361
https://doi.org/10.1002/jcp.24361
Summary Sirtuin-3 exhibits properties of a tumor suppressor partly emanating from its ability to control the state of mitochondrial metabolism, with depletion of sirt-3 increasing tumor cell survival. In the present study we demonstrate that depletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d028b29fce4e4618a8aaba1994b593
https://europepmc.org/articles/PMC6295652/
https://europepmc.org/articles/PMC6295652/
Autor:
John G. Pastorino, Nataly Shulga
Publikováno v:
Journal of Cell Science. 123:4117-4127
Ethanol increases the vulnerability of mitochondria to induction of the mitochondrial permeability transition (MPT). Cyclophilin-D activity enhances the potential for the permeability transition pore (PTP) to open. In the present study, we demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b61dab42225a938b5521fab1da93c0e
https://doi.org/10.1242/jcs.073502
https://doi.org/10.1242/jcs.073502
Autor:
Catherine Neary, John G. Pastorino
Publikováno v:
Biochemical and Biophysical Research Communications. 394:1075-1081
In yeast, the hexokinase type II enzyme (HXKII) translocates to the nucleus in the presence of excess glucose, and participates in glucose repression. However, no evidence has suggested a nuclear function for HXKII in mammalian cells. Herein, we pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf321320985cb562011b0c6692ae5ecb
https://doi.org/10.1016/j.bbrc.2010.03.129
https://doi.org/10.1016/j.bbrc.2010.03.129
Publikováno v:
Cell Cycle. 8:3355-3364
Cancer cells are frequently glycolytic and over-express hexokinase II (HXK II). In cancer cells, the majority of hexokinase II is localized to the mitochondria through interaction with the voltage dependent anion channel (VDAC). Disruption in the bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240490fb5f7b83683569e6c0cfd2107f
https://doi.org/10.4161/cc.8.20.9853
https://doi.org/10.4161/cc.8.20.9853
Autor:
John G. Pastorino, Jan B. Hoek
Publikováno v:
Journal of Bioenergetics and Biomembranes. 40:171-182
Hexokinase isoforms I and II bind to mitochondrial outer membranes in large part by interacting with the outer membrane voltage-dependent anion channel (VDAC). This interaction results in a shift in the susceptibility of mitochondria to pro-apoptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acc6b18e7f6e319c9f2c3a2610832ab
https://doi.org/10.1007/s10863-008-9148-8
https://doi.org/10.1007/s10863-008-9148-8
Autor:
Martin E. Adelson, Mika K. Kaneko, Kingsley Yin, Evan Nevel, Mahnaz Fatahzadeh, Yongquan Shen, John G. Pastorino, Jhon A. Ochoa-Alvarez, Gary S. Goldberg, Evelyne Kalyoussef, Yukinari Kato, Lasse Jensen, Mary Ann Young, Joseph J. Lee, Edward P. Retzbach, David J. Kephart, Soly Baredes, Lisa Deluca-Rapone, Alan J. Shienbaum, Masaru Honma, Harini Krishnan
Publikováno v:
Oncotarget
Europe PubMed Central
Europe PubMed Central
Podoplanin (PDPN) is a unique transmembrane receptor that promotes tumor cell motility. Indeed, PDPN may serve as a chemotherapeutic target for primary and metastatic cancer cells, particularly oral squamous cell carcinoma (OSCC) cells that cause mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57abf3ea61e278e44ae0083230e95d6e
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120753
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120753
Autor:
John G. Pastorino, Nataly Shulga
Publikováno v:
Journal of Biological Chemistry. 281:30824-30833
Activation of calpain has been shown to occur in some contexts of cell injury and to be essential for loss of cell viability. Part of this may be mediated at the mitochondrial level. It has been demonstrated that calpain activity is necessary for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6111cf32706a82e2af71db8d39a54b
https://doi.org/10.1074/jbc.m602503200
https://doi.org/10.1074/jbc.m602503200