Zobrazeno 1 - 10
of 18
pro vyhledávání: '"John G. Noel"'
Autor:
Yasuaki Uehara, Yusuke Tanaka, Shuyang Zhao, Nikolaos M. Nikolaidis, Lori B. Pitstick, Huixing Wu, Jane J. Yu, Erik Zhang, Yoshihiro Hasegawa, John G. Noel, Jason C. Gardner, Elizabeth J. Kopras, Wendy D. Haffey, Kenneth D. Greis, Jinbang Guo, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Jennifer E. Kyle, Charles Ansong, Steven L. Teitelbaum, Yoshikazu Inoue, Göksel Altinişik, Yan Xu, Francis X. McCormack
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Osteoclasts are derived from circulating myeloid cells to mediate bone repair, maintenance and remodeling. Here, the authors show that the lung also recruits and reprograms monocytes and alveolar macrophages into osteoclast-like cells to clear pathog
Externí odkaz:
https://doaj.org/article/31bc357b81304579bc6ef7c4759424c7
Autor:
John G. Noel, Seth W. Ramser, Lori Pitstick, John P. Bonamer, Bryan Mackenzie, Katie G. Seu, Theodosia A. Kalfa, Jose A. Cancelas, Jason C. Gardner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract M-CSF receptor signaling supports the development and survival of mononuclear phagocytes and is thought to play a role in post burn anemia by promoting myeloid lineage bias. We found M-CSF secretion was increased in burn patients and a murin
Externí odkaz:
https://doaj.org/article/574ad174994b4b668e96e765e451a0b2
Autor:
John G. Noel, Seth W. Ramser, Lori Pitstick, Holly S. Goetzman, Elizabeth L. Dale, Andrew Potter, Mike Adam, S. Steven Potter, Jason C. Gardner
Publikováno v:
The Journal of Immunology. 210:972-980
The anemia of critical illness (ACI) is a nearly universal pathophysiological consequence of burn injury and a primary reason burn patients require massive quantities of transfused blood. Inflammatory processes are expected to drive postburn ACI and
Autor:
Yoshihiro Hasegawa, Jennifer E. Kyle, Steven L. Teitelbaum, Huixing Wu, Nikolaos M. Nikolaidis, Kathryn A. Wikenheiser-Brokamp, Jane J. Yu, Kenneth D. Greis, John G. Noel, Yoshikazu Inoue, Erik Zhang, Jinbang Guo, Goksel Altinisik, Charles Ansong, Yasuaki Uehara, Elizabeth J. Kopras, Yan Xu, Jason C. Woods, Wendy D. Haffey, Yusuke Tanaka, Shuyang Zhao, Francis X. McCormack, Lori B. Pitstick, Jason D. Gardner
Pulmonary alveolar microlithiasis (PAM) is an autosomal recessive lung disease caused by a deficiency in the pulmonary epithelial Npt2b sodium-phosphate co-transporter that results in accumulation of phosphate and formation of hydroxyapatite microlit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9809f7e27ace417554f5eca29a4b1b0
https://doi.org/10.1101/2021.07.11.451970
https://doi.org/10.1101/2021.07.11.451970
Autor:
Jason D. Gardner, Atsushi Saito, Kara E Lewnard, Yasuaki Uehara, Lori B. Pitstick, Francis X. McCormack, Huixing Wu, Mitchell R. White, Kevan L. Hartshorn, Huan Liu, John G. Noel, Nikolaos M. Nikolaidis
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Development of pneumonia is the most lethal consequence of influenza, increasing mortality more than 50-fold compared with uncomplicated infection. The spread of viral infection from conducting airways to the alveolar epithelium is therefore a pivota
Publikováno v:
Experimental hematology. 56
Inflammation-mediated impairment of erythropoiesis plays a central role in the development of the anemia of critical illness (ACI). ACI develops despite elevation of endogenous erythropoietin (EPO), does not respond to exogenous erythropoietin (EPO)
Autor:
Francis X. McCormack, Cora K. Ogle, Bruce J. Aronow, Nikolaos M. Nikolaidis, Jason D. Gardner, Rebekah Karns, John G. Noel
Publikováno v:
The Journal of Immunology. 192:2405-2417
Traumatic injury is generally considered to have a suppressive effect on the immune system, resulting in increased susceptibility to infection. Paradoxically, we found that thermal injury to the skin induced a robust time-dependent protection of mice
Autor:
Huixing Wu, Francis X. McCormack, John G. Noel, Nikolaos M. Nikolaidis, Benjamin J. Ramser, Atsushi Saito, Jason D. Gardner, Lori B. Pitstick
Keratinocyte growth factor (KGF) is an epithelial mitogen that has been reported to protect the lungs from a variety of toxic and infectious insults. In prior studies we found that recombinant human KGF accelerates clearance of bacteria from the muri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405e1e952a78989c0c195d590fccda10
https://europepmc.org/articles/PMC4867350/
https://europepmc.org/articles/PMC4867350/
Autor:
John G. Noel, André Martignoni, Johannes Tschöp, Charles C. Caldwell, Cora K. Ogle, Timothy A. Pritts, Holly S. Goetzman, Alex B. Lentsch, Lisa G. Choi, Quan Wang, Jay A. Johannigman
Publikováno v:
Journal of Leukocyte Biology. 83:581-588
Sepsis is a difficult condition to treat and is associated with a high mortality rate. Sepsis is known to cause a marked depletion of lymphocytes, although the function of different lymphocyte subsets in the response to sepsis is unclear. gammadelta
Autor:
Sandy Schwemberger, Cora K. Ogle, Quan Wang, John G. Noel, Denise Byrum, Holly S. Goetzman, Andrew R. Osterburg, Xialing Guo, Charles C. Caldwell
Publikováno v:
Shock. 28:684-693
Recent publications have demonstrated that human resident and inflammatory monocyte (IM) subpopulations have equivalents in rodents. The effect of thermal injury upon these subpopulations has not been studied. Mice were given a scald burn and killed