Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John G. Mina"'
Publikováno v:
Pathogens, Vol 13, Iss 10, p 879 (2024)
We employed a BONCAT-iTRAQ labelling approach to investigate newly synthesised proteins (NSPs) in Toxoplasma gondii subjected to varying concentrations of the antifolate drug pyrimethamine. Our results reveal that numerous NSPs exhibited altered expr
Externí odkaz:
https://doaj.org/article/4346d727c7a8414b9360d1bf4af025a1
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characteri
Externí odkaz:
https://doaj.org/article/0507709fddc440fea2da4b0dab5db736
Autor:
Zisis Koutsogiannis, John G. Mina, Christin A. Albus, Matthijs A. Kol, Joost C. M. Holthuis, Ehmke Pohl, Paul W. Denny
Toxoplasma gondii is an obligate, intracellular eukaryotic apicomplexan protozoan parasite that can cause foetal damage and abortion in both animals and humans. Sphingolipids have indispensable functions as signaling molecules and are essential and u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a51278a9839979c6b6a90b60cee02301
https://doi.org/10.1101/2022.01.05.475179
https://doi.org/10.1101/2022.01.05.475179
Autor:
John G. Mina, Emily A. Dickie, Edubiel A. Alpizar-Sosa, Paul W. Denny, Chris Brown, Maria Paula Gonçalves Borsodi, Cláudia P. Figueiredo, Wenbin Wei, Robson Coutinho-Silva, Douglas O. Escrivani, Emanuelle V. de Lima, Bartira Rossi-Bergmann, Andy Merritt, Amjed Qays Al-Qaisi, Patrick G. Steel, Michael P. Barrett, Rebecca L Charlton, Terry K. Smith
Publikováno v:
ACS infectious diseases, 2021, Vol.7(1), pp.47-63 [Peer Reviewed Journal]
We thank CNPq (PVE Grant: 400894/2014-9 to B.R.-B. and P.G.S.), The Royal Society (The Royal Society International Collaboration Awards for Research Professors 2016: IC160044 to B.R.-B. and P.G.S.), MRC (iCASE studentship for C.B.; Grant MR/M020118/1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68269bc68eb5c08c88f7c95185bf53a9
https://hdl.handle.net/10023/21321
https://hdl.handle.net/10023/21321
Autor:
Paul W. Denny, Ehmke Pohl, Amjed Qays Al-Qaisi, Morten K. Grøftehauge, Louise E. Bird, Hosam Shams-Eldin, Julie K. Thye, Steven Pratt, Robert H. Dods, Jackie A. Mosely, John G. Mina, Ralph T. Schwarz
Publikováno v:
The Journal of Biological Chemistry
Journal of biological chemistry, 2017, Vol.292(29), pp.12208-12219 [Peer Reviewed Journal]
Journal of biological chemistry, 2017, Vol.292(29), pp.12208-12219 [Peer Reviewed Journal]
Toxoplasma gondii is an obligate, intracellular eukaryotic apicomplexan protozoan parasite that can cause fetal damage and abortion in both animals and humans. Sphingolipids are essential and ubiquitous components of eukaryotic membranes that are bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7d2f9725c0290d3ed912353f3931f1
https://doi.org/10.1074/jbc.m117.792374
https://doi.org/10.1074/jbc.m117.792374
Autor:
Peter Luemmen, Elizabeth C. Pinneh, Marc R. Knight, Michael J. R. Stark, Patrick G. Steel, Paul W. Denny, John G. Mina, Stephen D. Lindell
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific reports, 2019, Vol.9, pp.8083 [Peer Reviewed Journal]
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific reports, 2019, Vol.9, pp.8083 [Peer Reviewed Journal]
Resistance to 157 different herbicides and 88% of known sites of action has been observed, with many weeds resistant to two or more modes. Coupled with tighter environmental regulation, this demonstrates the need to identify new modes of action and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0973fa62804792866da60492c6e05cb7
https://doi.org/10.1038/s41598-019-44544-1
https://doi.org/10.1038/s41598-019-44544-1
Autor:
Dina G Hassan, Dagmar Müller, Patrick Niekamp, Siewert J. Marrink, Shashank Dadsena, Guilherme Razzera, Markus Schneider, Sergei Korneev, Manuel N. Melo, Joost C. M. Holthuis, John G. Mina, Helene Jahn, Svenja Bockelmann, Fikadu G. Tafesse
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, 10(1):1832. Nature Publishing Group
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, 10(1):1832. Nature Publishing Group
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Ceramides draw wide attention as tumor suppressor lipids that act directly on mitochondria to trigger apoptotic cell death. However, molecular details of the underlying mechanism are largely unknown. Using a photoactivatable ceramide probe, we here i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3790622a3c6c1797871e9a1e543de07
https://doi.org/10.1038/s41467-019-09654-4
https://doi.org/10.1038/s41467-019-09654-4
Autor:
John G. Mina, Gonzalo Colmenarejo, Patrick G. Steel, Juan Cantizani, Emilio Alvarez, Jennifer L. Norcliffe, Francisco de Dios-Anton, Paul W. Denny, Maria L. Marco, Silva Gonzalez-Del Valle, Julio Martin, Jose M. Fiandor
Publikováno v:
Scientific reports, 2018, Vol.8, pp.3938 [Peer Reviewed Journal]
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the world’s poorest, however vaccines are absent and drug therapy limited. Recently, public-privat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5540a9d8dbe8f9e9476de1b76014155
http://dro.dur.ac.uk/24221/1/24221.pdf
http://dro.dur.ac.uk/24221/1/24221.pdf
Autor:
Chris Brown, John G. Mina, Ariel Mariano Silber, Norton Heise, Danilo C. Miguel, Paul W. Denny, Silvia R. B. Uliana, Cristiana T. Trinconi
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 475-487 (2018)
International journal for parasitology : drugs and drug resistance, 2018, Vol.8(3), pp.475-487 [Peer Reviewed Journal]
International Journal for Parasitology: Drugs and Drug Resistance
Universidade de São Paulo (USP)
instacron:USP
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 475-487 (2018)
International journal for parasitology : drugs and drug resistance, 2018, Vol.8(3), pp.475-487 [Peer Reviewed Journal]
International Journal for Parasitology: Drugs and Drug Resistance
Previous work from our group showed that tamoxifen, an oral drug that has been in use for the treatment of breast cancer for over 40 years, is active both in vitro and in vivo against several species of Leishmania, the etiological agent of leishmania
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5739fe479d1356764767cba4fc89ffba
Autor:
John G. Mina, Paul W. Denny
Publikováno v:
Parasitology
Parasitology, 2018, Vol.145(2), pp.134-147 [Peer Reviewed Journal]
Parasitology, 2018, Vol.145(2), pp.134-147 [Peer Reviewed Journal]
SUMMARYSphingolipids (SLs) are an integral part of all eukaryotic cellular membranes. In addition, they have indispensable functions as signalling molecules controlling a myriad of cellular events. Disruption of either the de novo synthesis or the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebf07275023d8db25359985ec811fd2
https://pubmed.ncbi.nlm.nih.gov/28637533
https://pubmed.ncbi.nlm.nih.gov/28637533