Zobrazeno 1 - 10
of 50
pro vyhledávání: '"John G. Lock"'
Autor:
Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters, Tyler Shai-Hee, Riccardo Cazzoli, Merryn Brettle, Iveta Slapetova, Maria Kasherman, Renee Whan, Fernando Souza-Fonseca-Guimaraes, Linda Vahdat, David Ziegler, John G. Lock, Federico M. Giorgi, KumKum Khanna, Orazio Vittorio
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicated in cancer progressi
Externí odkaz:
https://doaj.org/article/b17391f9a29d4891bcdc6914896812f8
Autor:
Tanzila Khan, John G. Lock, Yafeng Ma, David G. Harman, Paul de Souza, Wei Chua, Bavanthi Balakrishnar, Kieran F. Scott, Therese M. Becker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Androgen receptor variant 7 (AR-V7) is an important biomarker to guide treatment options for castration-resistant prostate cancer (CRPC) patients. Its detectability in circulating tumour cells (CTCs) opens non-invasive diagnostic avenues. Wh
Externí odkaz:
https://doaj.org/article/d06bbbb8a6c34c748da9fb0465a71580
Autor:
Alexander Tong, Manik Kuchroo, Shabarni Gupta, Aarthi Venkat, Beatriz P. San Juan, Laura Rangel, Brandon Zhu, John G. Lock, Christine L. Chaffer, Smita Krishnaswamy
While single-cell technologies have allowed scientists to characterize cell states that emerge during cancer progression through temporal sampling, connecting these samples over time and inferring gene-gene relationships that promote cancer plasticit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12522e1f646e70dd5b2cf4082a217d08
https://doi.org/10.1101/2023.03.28.534644
https://doi.org/10.1101/2023.03.28.534644
Autor:
Daniel B. Burkhardt, Beatriz P. San Juan, John G. Lock, Smita Krishnaswamy, Christine L. Chaffer
Publikováno v:
Cancer Discov
Abstract Phenotypic plasticity describes the ability of cancer cells to undergo dynamic, nongenetic cell state changes that amplify cancer heterogeneity to promote metastasis and therapy evasion. Thus, cancer cells occupy a continuous spectrum of phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510d69f8df63abcdc5ba71c819adaaef
https://europepmc.org/articles/PMC9353259/
https://europepmc.org/articles/PMC9353259/
Autor:
Beatriz P San Juan, Soroor Hediyeh-Zadeh, Laura Rangel, Heloisa H Milioli, Vanina Rodriguez, Abigail Bunkum, Felix V Kohane, Carley A Purcell, Dharmesh D Bhuva, Anie Kurumlian, Lesley Castillo, Elgene Lim, Anthony J Gill, Vinod Ganju, Rachel Dear, Sandra O’Toole, A. Cristina Vargas, Theresa E Hickey, Leonard D Goldstein, John G Lock, Melissa J Davis, Christine L Chaffer
Cancer cells invoke phenotypic plasticity programs to drive disease progression and evade chemotherapeutic insults, yet until now there have been no validated clinical therapies targeting this process. Here, we identify a phenotypic plasticity signat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::145b8a5d43554f38060d619bca524413
https://doi.org/10.1101/2022.03.21.22269988
https://doi.org/10.1101/2022.03.21.22269988
Publikováno v:
Current Opinion in Chemical Biology. 51:40-47
The actin cytoskeleton is dysregulated in cancer, yet this critical cellular machinery has not translated as a druggable clinical target due to cardio-toxic side-effects. Many actin regulators are also considered undruggable, being structural protein
Autor:
Beatriz P. San Juan, Soroor Hediyah-Zadeh, Laura Rangel, Vanina Rodriguez, Heloisa H. Milioli, Felix Kohane, Carley A. Purcell, Therese E. Hickey, Leonard D. Goldstein, John G. Lock, Melissa J. Davis, Christine L. Chaffer
Publikováno v:
Cancer Research. 82:1029-1029
Therapeutic strategies that improve survival outcomes for advanced-stage breast cancers have proven a major clinical challenge. Here, we define an androgen receptor (AR) signalling network that governs the maintenance and de novo formation of cancer
Autor:
John G Lock, Mehrdad Jafari Mamaghani, Hamdah Shafqat-Abbasi, Xiaowei Gong, Joanna Tyrcha, Staffan Strömblad
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90593 (2014)
Heterogeneous and dynamic single cell migration behaviours arise from a complex multi-scale signalling network comprising both molecular components and macromolecular modules, among which cell-matrix adhesions and F-actin directly mediate migration.
Externí odkaz:
https://doaj.org/article/8242f4a16cd14b78a414665ea4073b58
Publikováno v:
Machine Learning in Medical Imaging ISBN: 9783030875886
MLMI@MICCAI
MLMI@MICCAI
High-content, microscopic image-based screening data are widely used in cell profiling to characterize cell phenotype diversity and extract explanatory biomarkers differentiating cell phenotypes induced by experimental perturbations or disease states
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfabc2ffddeb854fdd89d5f0e99f480c
https://doi.org/10.1007/978-3-030-87589-3_50
https://doi.org/10.1007/978-3-030-87589-3_50
Autor:
Mohammed Nimir, Paul de Souza, Tanzila Khan, Therese M. Becker, Yafeng Ma, John G. Lock, Kieran F. Scott
Publikováno v:
Prostate Cancer, Vol 2020 (2020)
Prostate Cancer
Prostate Cancer
Prostate cancer (PCa) is initially driven by excessive androgen receptor (AR) signaling with androgen deprivation therapy (ADT) being a major therapeutic approach to its treatment. However, the development of drug resistance is a significant limitati