Zobrazeno 1 - 10
of 26
pro vyhledávání: '"John G. Julias"'
Autor:
Stephen H. Hughes, Victor E. Marquez, Maqbool A. Siddiqui, John G. Julias, Zandrea Ambrose, Paul L. Boyer
Publikováno v:
Journal of Molecular Biology. 371:873-882
HIV-1 can become resistant to nucleoside analogs by developing an enhanced ability to excise the analogs after they have been incorporated. Excision requires that the analog be located at the 3′ terminus of the primer. We have describe nucleoside a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f28eb9eaefff2fb0e5c07226320eb0
https://doi.org/10.1016/j.jmb.2007.05.043
https://doi.org/10.1016/j.jmb.2007.05.043
Autor:
Mohammed M. Hossain, Karsten Krogh-Jespersen, Patrick K. Clark, Sanjeewa Dharmasena, Ronald M. Levy, Michael A. Parniak, Daniel M. Himmel, John G. Julias, Kessler McCoy-Simandle, Stephen H. Hughes, Tatiana V Ilina, Arthur D. Clark, Jennifer L. Knight, Eddy Arnold, Stefan G. Sarafianos
Publikováno v:
ACS Chemical Biology. 1:702-712
The rapid emergence of drug-resistant variants of human immunodeficiency virus, type 1 (HIV-1), has limited the efficacy of anti-acquired immune deficiency syndrome (AIDS) treatments, and new lead compounds that target novel binding sites are needed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0954aaf9258be68dbaba7436420c0e34
https://doi.org/10.1021/cb600303y
https://doi.org/10.1021/cb600303y
Publikováno v:
Virology. 317(1):136-145
The human T cell leukemia virus type 1 (HTLV-1) genome contains a cluster of at least five open reading frames (ORFs) near the 3′ terminus within the pX region. The pX ORFs are encoded by mono- or bicistronic mRNAs that are generated by alternative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc76c9afd7b2eec7e5ebe9194ae3e305
Autor:
Stefan G. Sarafianos, John G. Julias, Stephen H. Hughes, Mary Jane McWilliams, Edward Arnold, W. Gregory Alvord
Publikováno v:
Journal of Virology. 77:11150-11157
The RNase H activity of retroviral reverse transcriptases (RTs) degrades viral genomic RNA after it has been copied into DNA, removes the tRNA used to initiate negative-strand DNA synthesis, and generates and removes the polypurine tract (PPT) primer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ef3519a1c105aeedbbf78edbf66b9e
https://doi.org/10.1128/jvi.77.20.11150-11157.2003
https://doi.org/10.1128/jvi.77.20.11150-11157.2003
Publikováno v:
Journal of Virology. 76:1762-1768
We constructed two versions of an RCASBP-based retroviral shuttle vector, RSVP (RCASBP shuttle vector plasmid), containing either the zeocin or blasticidin resistance gene. In this vector, the drug resistance gene is expressed in avian cells from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18b54c2f4a89bfa94ccac1a7c165446
https://doi.org/10.1128/jvi.76.4.1762-1768.2002
https://doi.org/10.1128/jvi.76.4.1762-1768.2002
Publikováno v:
Journal of Virology. 75:6537-6546
The amount of excess polymerase and RNase H activity in human immunodeficiency virus type 1 virions was measured by using vectors that undergo a single round of replication. Vectors containing wild-type reverse transcriptase (RT), vectors encoding th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562006de167f2f38bf0b5be5b87f6266
https://doi.org/10.1128/jvi.75.14.6537-6546.2001
https://doi.org/10.1128/jvi.75.14.6537-6546.2001
Autor:
Vinay K. Pathak, John G. Julias
Publikováno v:
Journal of Virology. 72:7941-7949
Deoxyribonucleoside triphosphate (dNTP) pool imbalances are associated with an increase in the rate of misincorporation and hypermutation during in vitro reverse transcription reactions. However, the effects of in vivo dNTP pool imbalances on the acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afced40baaf2e07dc218dee882bbda6
https://doi.org/10.1128/jvi.72.10.7941-7949.1998
https://doi.org/10.1128/jvi.72.10.7941-7949.1998
Publikováno v:
Journal of Virology. 71:4254-4263
It was previously observed that the nucleoside analog 5-azacytidine increased the spleen necrosis virus (SNV) mutation rate 13-fold in one cycle of retrovirus replication (V. K. Pathak and H. M. Temin, J. Virol. 66:3093-3100, 1992). Based on this obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d443f242142f4024877ac12c08c8d98d
https://doi.org/10.1128/jvi.71.6.4254-4263.1997
https://doi.org/10.1128/jvi.71.6.4254-4263.1997
Publikováno v:
Journal of Virology. 69:6839-6846
We have developed novel self-inactivating and self-activating retroviral vectors based on the previously observed high-frequency deletion of direct repeats. We constructed spleen necrosis virus (SNV)-based viral vectors that contained large direct re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7564c75408f606b35044f8d8babc6f76
https://doi.org/10.1128/jvi.69.11.6839-6846.1995
https://doi.org/10.1128/jvi.69.11.6839-6846.1995
Autor:
Vineet N. KewalRamani, Ilker Oztop, Ichiro Taniuchi, Yuan Li, Derya Unutmaz, Zandrea Ambrose, Joseph Sodroski, Taichiro Takemura, Thomas D. Martin, John M. Coffin, John G. Julias, Nick Vandegraaff, Dan R. Littman, Alan Engelman, Wendy Yuen, Stephen H. Hughes, KyeongEun Lee, Kenneth Shelton, Rui Wang, Joerg G. Baumann, Alok Mulky
SummaryHIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the retroviral preintegration complex (PIC), into the nucleus. Too large for passive diffusion through nuclear pore complexes (NPCs), PICs use cellular n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421278c0327eedfbe194bad5ece905de
https://europepmc.org/articles/PMC2841689/
https://europepmc.org/articles/PMC2841689/
