Výsledky vyhledávání - "John G. Gerber"

A Randomized, Placebo-Controlled Trial of Abacavir Intensification in HIV-1–Infected Adults With Virologic Suppression on a Protease Inhibitor–Containing Regimen

Autor: Judith S. Currier, Lisa M. Demeter, Roland L. Bassett, William Spreen, Ana Martinez, Gene D. Morse, Kathleen Squires, John W. Mellors, Margaret A. Fischl, Scott M. Hammer, Robert W. Coombs, John G. Gerber, Heather J. Ribaudo

Publikováno v: HIV Clinical Trials. 11:312-324

Background and Objective: Maximizing the durability of viral suppression is a key goal of antiretroviral therapy. The objective of AIDS Clinical Trials Group Study 372A was to determine whether the intensification strategy of adding abacavir to an ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ecdc08f2217d3b2f86668c4062d1f69
https://doi.org/10.1310/hct1105-312

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Hepatotoxicity and Gastrointestinal Intolerance When Healthy Volunteers Taking Rifampin Add Twice-Daily Atazanavir and Ritonavir

Autor: Lara Hosey, Laura Laughlin, Beverly Alston-Smith, Andrew R. Zolopa, David W. Haas, Carol Suckow, Edward P. Acosta, Michael Child, John G. Gerber, Susan L. Koletar, Richard Bertz, Michelle A. Kendall

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 50:290-293

Rifampin is the cornerstone of antituberculosis therapy, but induction of hepatic cytochrome P4503A by rifampin markedly lowers HIV protease inhibitor plasma concentrations.This phase 1, open-label, one-arm study was designed to assess pharmacokineti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7b384c581ddae0573a12e17cfa0336
https://doi.org/10.1097/qai.0b013e318189a7df

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Drug/Drug Interaction Between Lopinavir/Ritonavir and Rosuvastatin in Healthy Volunteers

Autor: Julie A. Predhomme, Dorie W. Hoody, Pamela Wolfe, Devon M Flynn, John G. Gerber, Jennifer J. Kiser

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 47:570-578

OBJECTIVES: This open-label, single-arm, pharmacokinetic (PK) study in HIV-seronegative volunteers evaluated the bioequivalence of rosuvastatin and lopinavir/ritonavir when administered alone and in combination. Tolerability and lipid changes were al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf08b54e736d26523ed5b716f423fc0
https://doi.org/10.1097/qai.0b013e318160a542

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Fish Oil and Fenofibrate for the Treatment of Hypertriglyceridemia in HIV-Infected Subjects on Antiretroviral Therapy

Autor: Douglas Kitch, Stéphannie Charles, Edward P. Acosta, Constance A. Benson, David A. Wohl, Robert Zackin, Evelyn Hogg, Elizabeth Connick, Judith A. Aberg, John G. Gerber, E. Milu Kojic, Carl J. Fichtenbaum

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 47:459-466

Before the introduction of highly active antiretroviral therapy (HAART), HIV-infected persons were noted to have elevated triglyceride (TG) levels with low total cholesterol and low high-density lipoprotein cholesterol (HDL-C), presumably attributabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8794e89689b008ce2722051ec55bafc0
https://doi.org/10.1097/qai.0b013e31815bace2

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Pharmacodynamics of Antiretroviral Agents in HIV-1 Infected Patients: Using Viral Dynamic Models that Incorporate Drug Susceptibility and Adherence

Autor: Hulin Wu, Alan S. Perelson, Joseph J. Eron, Song Yu, John G. Gerber, Yangxin Huang, Daniel R. Kuritzkes, Jeong Gun Park, Susan L. Rosenkranz, Edward P. Acosta

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 33:399-419

We developed a novel HIV-1 dynamic model with consideration of pharmacokinetics, drug adherence and drug susceptibility to link plasma drug concentration to the long-term changes in HIV-1 RNA observation after initiation of therapy. A Bayesian approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88940ebd8427db272a0cf52b3f57d172
https://doi.org/10.1007/s10928-006-9006-4

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Amdoxovir versus Placebo with Enfuvirtide plus Optimized Background Therapy for HIV-1-Infected Subjects Failing Current Therapy (Aactg A5118)

Autor: John G. Gerber, Daniel R. Kuritzkes, Barbara Gripshover, Heather J. Ribaudo, Bernadette Jarocki, Evelyn Hogg, Thomas B. Campbell, Jorge Santana, Scott M. Hammer

Publikováno v: Antiviral Therapy. 11:619-623

Background Amdoxovir (2,6-diaminopurine dioxolane; DAPD) is a nucleoside reverse transcriptase inhibitor (NRTI) of human immunodeficiency virus-1 (HIV-1) with activity against wild-type and NRTI-resistant viruses. Methods ACTG A5118 assessed the anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::283d482b0ef5e33738667a33adab755a
https://doi.org/10.1177/135965350601100504

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Indinavir protein-free concentrations when used in indinavir/ritonavir combination therapy

Autor: Edward P. Acosta, Lane R. Bushman, Jennifer R. King, John G. Gerber, Courtney V. Fletcher

Publikováno v: AIDS. 19:1059-1063

Objective: To describe the in vivo protein-binding characteristics of indinavir (IDV) in the presence of ritonavir (RTV) relative to total IDV plasma concentrations. Design: The ACTG protocol 5055 was a multicenter study comparing the safety and phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf16075101606a335e497ad27206568
https://doi.org/10.1097/01.aids.0000174452.78497.54

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Therapeutic drug monitoring: Pharmacologic considerations for antiretroviral drugs

Autor: Jennifer J. Kiser, John G. Gerber, Peter L. Anderson

Publikováno v: Current HIV/AIDS Reports. 2:61-67

Therapeutic drug monitoring (TDM) is the process by which a patient's dosing regimen is guided by repeated measures of plasma drug concentrations. An enormous challenge with regard to TDM of antiretroviral drugs (ARV) is that the concentration goals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5cd4be9aac30824bf38c18c8ae1d9a
https://doi.org/10.1007/s11904-005-0020-8

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Antiretroviral Drug Pharmacokinetics in Hepatitis with Hepatic Dysfunction

Autor: John G. Gerber, David L. Wyles

Publikováno v: Clinical Infectious Diseases. 40:174-181

Chronic viral hepatitis is common among persons with HIV-1 infection, because of shared modes of transmission, and coinfection results in accelerated liver damage, compared with persons with chronic viral hepatitis alone. The use of highly active ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0ce01776b5e9813350c6584497622f
https://doi.org/10.1086/426021

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Determination of the absolute configuration and solution conformation of the antifungal agents ketoconazole, itraconazole, and miconazole with vibrational circular dichroism

Autor: David Dunmire, Christine Aeschlimann, John G. Gerber, Laurence A. Nafie, Joseph Gal, Teresa B. Freedman

Publikováno v: Chirality. 17:S101-S108

The absolute configuration assignments of three antifungal agents, (+)-(2R,4S)-ketoconazole, (+)-(2R,4S)-itraconazole (with (S)-configuration at the sec-butyl group) and (+)-(S)-miconazole nitrate have been confirmed by using vibrational circular dic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e47a680a01418b8f5ab25bb8a313db
https://doi.org/10.1002/chir.20120

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