Zobrazeno 1 - 10
of 169
pro vyhledávání: '"John G. Forte"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 3, Pp 213-222 (2013)
The proposed mechanism for proton pump inhibitors (PPIs) is that PPIs are activated at low pH to the sulfenamide form, which reacts with the sulfhydryl group of cysteine(s) at the active site of the proton pump, to produce reducible disulfide-bonded
Externí odkaz:
https://doaj.org/article/1d17016dada344deb21b295ea64c7f8b
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 310:G671-G681
A computer model, constructed for evaluation of integrated functioning of cellular components involved in acid secretion by the gastric parietal cell, has provided new interpretations of older experimental evidence, showing the functional significanc
Autor:
Jonathan C. Trinidad, Susan S. Baker, Alma L. Burlingame, John G. Forte, Lauren P. Virtuoso, Lixin Zhu, Wensheng Liu, Nejat K. Egilmez, Robert D. Baker
Publikováno v:
Journal of Gastroenterology. 48:1343-1352
Proton pump inhibitors (PPIs) are pro-drugs requiring an acidic pH for activation. The specificity of PPI toward the proton pump is mainly due to the extremely low pH at the parietal cell canalicular membrane where the pump is located. Reactivity of
Autor:
Wensheng Liu, Robert D. Baker, Susan S. Baker, Lixin Zhu, Catherine S. Chew, John G. Forte, Wenjun He
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 301:G591-G600
Potassium ions are required for gastric acid secretion. Several potassium channels have been implicated in providing K+at the apical membrane of parietal cells. In examining the mRNA expression levels between gastric mucosa and liver tissue, KCNJ15 s
Autor:
Brigitte Riederer, Marian L. Miller, Penghong Song, Zhaohui Wang, Seth L. Alper, Gary E. Shull, Jie Xu, Manoocher Soleimani, John G. Forte, Ursula Seidler, Frank Borgese, Jordi Ehrenfeld, Sharon Barone
Publikováno v:
Proceedings of the National Academy of Sciences. 105:17955-17960
Slc26a9 is a recently identified anion transporter that is abundantly expressed in gastric epithelial cells. To study its role in stomach physiology, gene targeting was used to prepare mice lacking Slc26a9. Homozygous mutant (Slc26a9 −/− ) mice a
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 293:G532-G543
The gastric parietal cell is responsible for the secretion of HCl into the lumen of the stomach mainly due to stimulation by histamine via the cAMP pathway. However, the participation of several other receptors and pathways have been discovered to in
Publikováno v:
Biochemistry. 46:10145-10152
The gastric H,K-ATPase is related to other cation transport ATPases, for example, Na,K-ATPase and Ca-ATPase, which are called E1-E2 ATPases in recognition of conformational transitions during their respective transport and catalytic cycles. Generally
Autor:
Kai Jiang, Ya Liu, Mingye Feng, Xia Ding, Xue Yu, Dongmei Wang, Zhen Guo, Xuebiao Yao, Felix O. Aikhionbare, John G. Forte, Hui Deng, Min Wang, Tarsha Ward
Publikováno v:
FEBS Letters. 581:4318-4324
Syntaxin and Munc18 are essential for regulated exocytosis in all eukaryotes. It was shown that Munc18 inhibition of neuronal syntaxin 1 can be overcome by CDK5 phosphorylation, indicating that structural change disrupts the syntaxin–Munc18 interac
Autor:
Hui Deng, James W. Lillard, Xia Ding, Yong Miao, Siqi Liu, Yong Chen, Fengsong Wang, John G. Forte, Chuanhai Fu, Xuebiao Yao, Rihong Zhou, Michael D. Powell, Zhiyou Fang, Qicong Hu, Charles Watson
Publikováno v:
Molecular & Cellular Proteomics. 5:1437-1449
ARF6 GTPase is a conserved regulator of membrane trafficking and actin-based cytoskeleton dynamics at the leading edge of migrating cells. A key determinant of ARF6 function is the lifetime of the GTP-bound active state, which is orchestrated by GTPa
Publikováno v:
Journal of Cell Science. 118:4381-4391
Phosphorylation of the membrane-cytoskeleton linker protein ezrin has been functionally linked to acid secretion and vesicle recruitment to the apical secretory membrane in gastric parietal cells. Phosphorylation of the conserved T567 residue of ezri