Zobrazeno 1 - 6
of 6
pro vyhledávání: '"John G. Darker"'
Autor:
Melanie J. Robbins, Robert P. Davis, Guillaume Hervieu, Paul R. Murdock, Nicole C. Herrity, Catherine E. Ellis, Kim Winborn, Graham J. Riley, Jane E. Bolaky, Carol A. Jennings, Andrew D. Medhurst, John G. Darker, Kenneth W. M. Lawrie
Publikováno v:
Journal of Neurochemistry. 84:1162-1172
Apelin peptides have recently been identified to be the endogenous ligands for the G protein-coupled receptor APJ. However, little is known about the physiological roles of this ligand-receptor pairing. In the present study we investigated the pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36392cdd24cc186ec32c3f7da331b83
https://doi.org/10.1046/j.1471-4159.2003.01587.x
https://doi.org/10.1046/j.1471-4159.2003.01587.x
Publikováno v:
Journal of Peptide Science. 7:598-605
Analogues of the nonselective bombesin receptor synthetic agonist H-D-Phe-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH2 were prepared and their biological activity assessed at the NMB-preferring/bombesin receptor (NMB-R; BB1), the GRP-preferring/bombesin rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3b72ef91eb9d4443c540ac964a8e05
https://doi.org/10.1002/psc.359
https://doi.org/10.1002/psc.359
Autor:
A. Jacqueline Hunter, Declan N.C. Jones, Drake S. Eggleston, S J Bolton, John G. Darker, Frank S. Walsh
Publikováno v:
European Journal of Neuroscience. 12:2847-2855
Investigation of normal and pathological diseases of the central nervous system (CNS) has been hampered by the inability to effectively manipulate protein function in vivo. In order to address this important topic, we have evaluated the ability of pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b5366d0a1e82112aa49c0151409a1e1
https://doi.org/10.1046/j.1460-9568.2000.00171.x
https://doi.org/10.1046/j.1460-9568.2000.00171.x
Autor:
Richard L.M. Faull, Henry M. Sarau, Usman Shabon, Susan E. Middleton, Larissa Chamberlain, David C. Harrison, David Michalovich, Derk J. Bergsma, John G. Darker, Jon K. Chambers, Paul R. Murdock, Nabil Elshourbagy, Klaudia Steplewski, Darren J. Moore, Alison I. Muir, Piers C. Emson, Jane E. Miller, Christopher Larminie, Philip G. Szekeres, Shelagh Wilson, Karen L. Philpott, Amy Calamari
Publikováno v:
The Journal of biological chemistry. 276(31)
A novel human G protein-coupled receptor named AXOR12, exhibiting 81% homology to the rat orphan receptor GPR54, was cloned from a human brain cDNA library. Heterologous expression of AXOR12 in mammalian cells permitted the identification of three su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06f08a1737af88b48e97c20f1b98ce7
https://pubmed.ncbi.nlm.nih.gov/11387329
https://pubmed.ncbi.nlm.nih.gov/11387329
Autor:
Jeffrey C. Jerman, Darren Smart, Roderick A. Porter, John G. Darker, Cibele Sabido-David, Drake S. Eggleston, Stephen J. Brough
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(5)
Truncated peptide analogues of orexin-A were prepared and their biological activity assesed at the orexin-1 receptor. Progressive N-terminal deletions identified the minimum C-terminal sequence required for maintaining a significant agonist effect, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4a764db6bc0d948791ff9f2d624c70
https://pubmed.ncbi.nlm.nih.gov/11266181
https://pubmed.ncbi.nlm.nih.gov/11266181
Autor:
Julia A. Hubbard, Lesley K. Maclachlan, Eugene Meenan, Colin J. Salter, David G. Reid, Philippe Lahouratate, John Humphries, Nichola Stevens, David Bell, William A. Neville, Kenneth J. Murray, John G. Darker
Publikováno v:
Molecular membrane biology. 11(4)
Nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy have been used to characterize the conformation of the putative cytoplasmic domain of phospholamban (PLB), an oligomeric membrane-bound protein which regulates the activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0123395d2295ad5282241b691cd971c7
https://pubmed.ncbi.nlm.nih.gov/7711836
https://pubmed.ncbi.nlm.nih.gov/7711836