Výsledky vyhledávání - "John G. Collard"

Tumor Type-Dependent Function of the Par3 Polarity Protein in Skin Tumorigenesis

Autor: Wilhelmina E. van Riel, Tomonori Hirose, Sandra Iden, Ronny Schäfer, Shigeo Ohno, Ji-Ying Song, John G. Collard

Publikováno v: Cancer Cell. 22(3):389-403

SummaryCell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes. In mouse skin tumorigenesis, Par3 deficiency results in reduced papilloma formation and g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54734ad46344bfc8f393dd925906b51

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The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network

Autor: Sandra Iden, John G. Collard, Saskia I.J. Ellenbroek

Publikováno v: Small GTPases
Small GTPases; Vol 3

Polarized cell migration is a crucial process in the development and repair of tissues, as well as in pathological conditions, including cancer. Recent studies have elucidated important roles for Rho GTPases in the establishment and maintenance of po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dcb7b7bfdf5b36863a38a2bfdf0676
http://europepmc.org/articles/PMC3398916

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Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling

Autor: Rob A. van der Kammen, Amra Hajdo-Milasinovic, John G. Collard, Zvezdana Moneva

Publikováno v: Journal of Cell Science. 122:2127-2136

Rac1 and Rac3 are highly homologous regulatory proteins that belong to the small GTPases of the Rho family. Previously, we showed that Rac3 induces cell rounding and prevents neuronal differentiation, in contrast to its close relative Rac1, which sti

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https://doi.org/10.1242/jcs.039958

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Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice

Autor: Tomasz P. Rygiel, John G. Collard, M. A. Van Der Valk, Kristin Strumane

Publikováno v: Journal of Cancer Research and Clinical Oncology. 135:69-80

Rho-like small GTPases, including RhoA, Rac1 and Cdc42, are crucial for the regulation of a large variety of biological processes such as the cytoskeletal organization and gene transcription. The activities of Rho GTPases are predominantly controlled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0f4b1a51f60cae6582590971d5aa0c
https://doi.org/10.1007/s00432-008-0437-8

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Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency

Autor: Kristin Strumane, Inge Baas, John G. Collard, Ji-Ying Song

Publikováno v: Leukemia Research. 32:113-120

Mutation of the tumor suppressor PTEN results in loss of its PI3-kinase counteracting function. PI3-kinase stimulates tumor formation by PKB/Akt-mediated cell proliferation and prevention of apoptosis. PI3-kinase may also activate Rho-GTPases and the

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https://doi.org/10.1016/j.leukres.2007.03.034

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Prognostic relevance of Tiam1 protein expression in prostate carcinomas

Autor: John G. Collard, Rainer Engers, Reinhart Willers, Helmut E. Gabbert, A Walter, Mirko Mueller

Publikováno v: British Journal of Cancer

The Rac-specific guanine nucleotide exchange factor, Tiam1, plays a major role in oncogenicity, tumour invasion and metastasis but its usefulness as a prognostic marker in human cancer has not been tested yet. In the present study, Tiam1 expression w

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https://doi.org/10.1038/sj.bjc.6603385

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Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization

Autor: Peter L. Hordijk, Laura M. Machesky, Jean Paul ten Klooster, John G. Collard, Lennert Janssen, Eva E. Evers, Frits Michiels

Publikováno v: Biochemical Journal, 397(1), 39-45. Portland Press Ltd.
Biochemical journal, 397(1), 39-45. Portland Press Ltd.
Ten Klooster, J P, Evers, E E, Janssen, L, Machesky, L M, Michiels, F, Hordijk, P & Collard, J G 2006, ' Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization ', Biochemical Journal, vol. 397, no. 1, pp. 39-45 . https://doi.org/10.1042/BJ20051957

The Rac-specific GEF (guanine-nucleotide exchange factor) Tiam1 (T-lymphoma invasion and metastasis 1) regulates migration, cell–matrix and cell–cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Using yeast two-hybrid s

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http://www.scopus.com/inward/record.url?scp=33745550075&partnerID=8YFLogxK

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Tiam1 takes PARt in cell polarity

Autor: Alexander E.E. Mertens, John G. Collard, D. Michiel Pegtel

Publikováno v: Mertens, A E E, Pegtel, D M & Collard, J G 2006, ' Tiam1 takes PARt in cell polarity ', Trends in Cell Biology, vol. 16, no. 6, pp. 308-316 . https://doi.org/10.1016/j.tcb.2006.04.001

Cell polarity is an essential requirement for the proper tissue development of complex organisms. This is underscored by in vivo studies showing that loss of cell polarity contributes to the formation and progression of tumours. Evolutionary conserve

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https://doi.org/10.1016/j.tcb.2006.04.001

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