Zobrazeno 1 - 10
of 177
pro vyhledávání: '"John G R, Jefferys"'
Autor:
Alexandru Cǎlin, Mihai Stancu, Ana-Maria Zagrean, John G. R. Jefferys, Andrei S. Ilie, Colin J. Akerman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Current anti-epileptic medications that boost synaptic inhibition are effective in reducing several types of epileptic seizure activity. Nevertheless, these drugs can generate significant side-effects and even paradoxical responses due to the broad n
Externí odkaz:
https://doaj.org/article/4b36f912b4424017bad971bdbff653c4
Publikováno v:
Epilepsia
Objective To test the hypothesis that death with physiological parallels to human cases of sudden unexpected death in epilepsy (SUDEP) can be induced in seizing rats by ictal activation of oxygen-conserving reflexes (OCRs). Methods Urethane-anestheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9e11f04e1790d80b99f544c2b249f4
https://doi.org/10.1111/epi.16831
https://doi.org/10.1111/epi.16831
Autor:
Christian Meisel, Viktor K. Jirsa, Klaus Lehnertz, Andreas Schulze-Bonhage, Gregory A. Worrell, John G. R. Jefferys, Mark Goodfellow, Premysl Jiruska, Bjoern Schelter, Catherine A. Schevon, Rasesh B. Joshi, Hitten P. Zaveri
Publikováno v:
Seizure
Seizure-European Journal of Epilepsy
Seizure-European Journal of Epilepsy, 2020, 78, pp.78-85. ⟨10.1016/j.seizure.2020.03.010⟩
Seizure-European Journal of Epilepsy
Seizure-European Journal of Epilepsy, 2020, 78, pp.78-85. ⟨10.1016/j.seizure.2020.03.010⟩
Debates on six controversial topics on the network theory of epilepsy were held during two debate sessions, as part of the International Conference for Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the University of Exeter, UK,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4250a04a258e3b73c5b1e89013b01646
https://doi.org/10.1016/j.seizure.2020.03.010
https://doi.org/10.1016/j.seizure.2020.03.010
Publikováno v:
Jefferys, J G R, Ashby-Lumsden, A & Lovick, T A 2020, ' Cardiac effects of repeated focal seizures in rats induced by intrahippocampal tetanus toxin : bradyarrhythmias, tachycardias and prolonged interictal QT interval ', Epilepsia . https://doi.org/10.1111/epi.16479
Objective To determine electrical changes in the heart in a chronic, nonstatus model of epilepsy. Methods Electrocorticography (ECoG) and electrocardiography (ECG) of nine animals (five made epileptic by intrahippocampal injection of tetanus neurotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0923f5ede2bf935cd1069a007f5c2b2
https://doi.org/10.1111/epi.16479
https://doi.org/10.1111/epi.16479
Publikováno v:
Seizure. 75:137-144
The pathophysiology leading to the development of status epilepticus (SE) remains a topic of significant scientific interest and clinical relevance. The use of multiple experimental and computational models has shown that SE relies on a complex inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e187de85baa3ce57d4d1f0b26b9ccbb2
https://doi.org/10.1016/j.seizure.2019.09.012
https://doi.org/10.1016/j.seizure.2019.09.012
The study of cortical oscillations is of great interest to those working in many areas of neuroscience. A fast coherent EEG rhythm called gamma or'40 Hz'has been implicated in cognition, as it may play a role in binding together features of objects.
Publikováno v:
Epilepsy Behav
OBJECTIVE: To investigate carotid body (CB) mechanisms related to sudden death during seizure. Ictal activation of oxygen-conserving reflexes (OCRs) can trigger fatal cardiorespiratory collapse in seizing rats, which presents like human sudden unexpe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77faab364cb33d55c2aaafccd680cea8
https://doi.org/10.1016/j.yebeh.2022.108918
https://doi.org/10.1016/j.yebeh.2022.108918
Autor:
Gabriel O. Albors, John G. R. Jefferys, Pedro P. Irazoqui, Daniel J. Pederson, Jesse P. Somann, Christopher J. Quinkert, Zhi Wang, Muhammad Abdullah Arafat, Rebecca A. Bercich, Jack Williams
Publikováno v:
ACM Transactions on Embedded Computing Systems. 18:1-20
Implantable closed-loop neuromodulation devices for use in long-term chronic studies in a lab or clinical trial are expensive to acquire and difficult to modify for specific use cases. This article documents the design and fabrication of a wireless i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea6c22cd3be0fcdeaa5dcad3e89e02df
https://doi.org/10.1145/3301310
https://doi.org/10.1145/3301310
Autor:
Andrew D Powell, Pierre-Philippe Saintot, Kalbinder K Gill, Ashtami Bharathan, S Caroline Buck, Gareth Morris, Premysl Jiruska, John G R Jefferys
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95871 (2014)
Intellectual disability affects 2-3% of the population; mutations of the X-chromosome are a major cause of moderate to severe cases. The link between the molecular consequences of the mutation and impaired cognitive function remains unclear. Loss of
Externí odkaz:
https://doaj.org/article/fabc3018c0c546918c6f45aef1968598
Autor:
John G. R. Jefferys, Thelma A. Lovick
Publikováno v:
Autonomic neuroscience : basicclinical. 235
The risk factors for SUDEP are undoubtedly heterogenous but the main factor is the frequency of generalized tonic-clonic seizures with apnoea and/or cardiac abnormalities likely precipitating the lethal event. By its very nature modelling SUDEP exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1a36097e44945911fa03f314cbfffc
https://pubmed.ncbi.nlm.nih.gov/34428716
https://pubmed.ncbi.nlm.nih.gov/34428716