Výsledky vyhledávání - "John G R, Jefferys"

Akademický článek

Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity

Autor: Alexandru Cǎlin, Mihai Stancu, Ana-Maria Zagrean, John G. R. Jefferys, Andrei S. Ilie, Colin J. Akerman

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Current anti-epileptic medications that boost synaptic inhibition are effective in reducing several types of epileptic seizure activity. Nevertheless, these drugs can generate significant side-effects and even paradoxical responses due to the broad n

Externí odkaz: https://doaj.org/article/4b36f912b4424017bad971bdbff653c4

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Ictal activation of oxygen‐conserving reflexes as a mechanism for sudden death in epilepsy

Autor: Pedro P. Irazoqui, John G. R. Jefferys, Ethan N. Biggs, Ryan B. Budde

Publikováno v: Epilepsia

Objective To test the hypothesis that death with physiological parallels to human cases of sudden unexpected death in epilepsy (SUDEP) can be induced in seizing rats by ictal activation of oxygen-conserving reflexes (OCRs). Methods Urethane-anestheti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9e11f04e1790d80b99f544c2b249f4
https://doi.org/10.1111/epi.16831

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Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference

Autor: Christian Meisel, Viktor K. Jirsa, Klaus Lehnertz, Andreas Schulze-Bonhage, Gregory A. Worrell, John G. R. Jefferys, Mark Goodfellow, Premysl Jiruska, Bjoern Schelter, Catherine A. Schevon, Rasesh B. Joshi, Hitten P. Zaveri

Publikováno v: Seizure
Seizure-European Journal of Epilepsy
Seizure-European Journal of Epilepsy, 2020, 78, pp.78-85. ⟨10.1016/j.seizure.2020.03.010⟩

Debates on six controversial topics on the network theory of epilepsy were held during two debate sessions, as part of the International Conference for Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the University of Exeter, UK,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4250a04a258e3b73c5b1e89013b01646
https://doi.org/10.1016/j.seizure.2020.03.010

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Cardiac effects of repeated focal seizures in rats induced by intrahippocampal tetanus toxin: Bradyarrhythmias, tachycardias, and prolonged interictal QT interval

Autor: Thelma A. Lovick, Alexander Ashby‐Lumsden, John G. R. Jefferys

Publikováno v: Jefferys, J G R, Ashby-Lumsden, A & Lovick, T A 2020, ' Cardiac effects of repeated focal seizures in rats induced by intrahippocampal tetanus toxin : bradyarrhythmias, tachycardias and prolonged interictal QT interval ', Epilepsia . https://doi.org/10.1111/epi.16479

Objective To determine electrical changes in the heart in a chronic, nonstatus model of epilepsy. Methods Electrocorticography (ECoG) and electrocardiography (ECG) of nine animals (five made epileptic by intrahippocampal injection of tetanus neurotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0923f5ede2bf935cd1069a007f5c2b2
https://doi.org/10.1111/epi.16479

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The transition to status epilepticus: how the brain meets the demands of perpetual seizure activity

Autor: Richard J Burman, Arjune Sen, John G. R. Jefferys, Joseph V Raimondo, Colin J. Akerman

Publikováno v: Seizure. 75:137-144

The pathophysiology leading to the development of status epilepticus (SE) remains a topic of significant scientific interest and clinical relevance. The use of multiple experimental and computational models has shown that SE relies on a complex inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e187de85baa3ce57d4d1f0b26b9ccbb2
https://doi.org/10.1016/j.seizure.2019.09.012

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Elektronická kniha

Fast Oscillations in Cortical Circuits

Autor: Roger D. Traub, Miles A. Whittington, John G. R. Jefferys

The study of cortical oscillations is of great interest to those working in many areas of neuroscience. A fast coherent EEG rhythm called gamma or'40 Hz'has been implicated in cognition, as it may play a role in binding together features of objects.

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Carotid body stimulation as a potential intervention in sudden death in epilepsy

Autor: Ethan N, Biggs, Ryan B, Budde, John G R, Jefferys, Pedro P, Irazoqui

Publikováno v: Epilepsy Behav

OBJECTIVE: To investigate carotid body (CB) mechanisms related to sudden death during seizure. Ictal activation of oxygen-conserving reflexes (OCRs) can trigger fatal cardiorespiratory collapse in seizing rats, which presents like human sudden unexpe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77faab364cb33d55c2aaafccd680cea8
https://doi.org/10.1016/j.yebeh.2022.108918

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