Zobrazeno 1 - 10
of 101
pro vyhledávání: '"John G Frelinger"'
Publikováno v:
BioTechniques, Vol 74, Iss 5, Pp 237-241 (2023)
Here, the authors report a simple method to perform antigen retrieval using a commonly available commercial Instant Pot® for immunohistochemistry. It provides a validated alternative to previous antigen retrieval methods that employ water baths, mic
Externí odkaz:
https://doaj.org/article/2ee884521237436085dc1c515739322d
Publikováno v:
J Interferon Cytokine Res
Cytokines are powerful mediators of immune responses and some, such as interleukin-2 (IL-2), have achieved dramatic responses as cancer immunotherapies. Unfortunately, systemic administration often results in deleterious side effects, prompting explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac633e3b06b48aa47f9775e257d51e0
https://doi.org/10.1089/jir.2022.0043
https://doi.org/10.1089/jir.2022.0043
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Educating the next generation of physicians is a key means of communicating and disseminating impactful immunologic scientific knowledge, and its practical application to human disease. We present our perspective, using as our model a first-year medi
Externí odkaz:
https://doaj.org/article/71a2cde401134267a66292d776600807
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
This Research Topic addresses issues relevant to teaching of modern immunology, a field that has exploded in recent years and is constantly evolving. These articles encompass curricular innovation, new pedagogical strategies, and teaching tools for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c419f45a3aefc65e6691ccca013b7b8d
https://www.frontiersin.org/articles/10.3389/fimmu.2021.744090/full
https://www.frontiersin.org/articles/10.3389/fimmu.2021.744090/full
Interleukin-12 (IL-12) is a pleiotropic cytokine that has profound effects on many aspects of cell-mediated responses and can enhance antitumor responses in experimental models. IL-12 has been tested clinically, however, side-effects have limited its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4497029d4401b6803175b6c3dd6e18
https://europepmc.org/articles/PMC6479256/
https://europepmc.org/articles/PMC6479256/
Publikováno v:
The Journal of Immunology. 204:246.9-246.9
Cytokines are potent immune mediators and play a crucial role in the differentiation and activation of effector CD8 T cells which are critical in anti-tumor responses. Here we tested the ability of IL-2, IL-12, and IL-18 to drive expression of gamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9137b3cfbfc03b664fc6666c7eb4c1f9
https://doi.org/10.4049/jimmunol.204.supp.246.9
https://doi.org/10.4049/jimmunol.204.supp.246.9
Publikováno v:
Journal of Interferon & Cytokine Research. 35:690-697
Interleukin-12 (IL-12), a potent inducer of interferon gamma (IFNγ), is a heterodimeric protein consisting of p40 and p35 subunits whose expression is regulated independently. IL-12 is part of a cytokine family (currently consisting of IL-12, IL-23,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d12ecadebc190e9ab050530c6e944c4
https://doi.org/10.1089/jir.2014.0176
https://doi.org/10.1089/jir.2014.0176
Autor:
Denise Skrombolas, John G. Frelinger
Publikováno v:
Expert Review of Clinical Immunology. 10:207-217
Interleukin-2 (IL-2) is a cytokine with pleiotropic effects on the immune system. Systemic IL-2 treatment has produced durable responses in melanoma and renal cancer patients, but unfortunately this is effective only in a fraction of patients. Moreov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a678d7f1b34ddc3cb7cdbf8ee82d4354
https://doi.org/10.1586/1744666x.2014.875856
https://doi.org/10.1586/1744666x.2014.875856
Autor:
Abigail Sedlacek, Denise Skrombolas, Joanne Y.H. Lim, John G. Frelinger, Scott A. Gerber, Elizabeth W. Sorensen, Edith M. Lord
Publikováno v:
Immunology
The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0985fed5dce449e5bf3e2c3973e33600
Autor:
Sharon S. Evans, Joseph J. Skitzki, Andrew D. Luster, Maryann Mikucki, Thomas F. Gajewski, Kunle Odunsi, John G. Frelinger
Publikováno v:
Oncoimmunology
Promising cancer immunotherapeutics depend on mobilization of cytotoxic T cells across tumor vascular barriers through mechanisms that are poorly understood. Recently, we discovered that the CXCR3 chemokine receptor uniquely functions as the master-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9597fe54382b996210dffc85b98bff8b
http://europepmc.org/articles/PMC4910745
http://europepmc.org/articles/PMC4910745