Zobrazeno 1 - 10
of 18
pro vyhledávání: '"John G Emery"'
Autor:
Jong W Yu, Sandy Hoffman, Allison M Beal, Angela Dykon, Michael A Ringenberg, Anna C Hughes, Lauren Dare, Amber D Anderson, Joshua Finger, Viera Kasparcova, David Rickard, Scott B Berger, Joshi Ramanjulu, John G Emery, Peter J Gough, John Bertin, Kevin P Foley
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127083 (2015)
CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and other pathways. Previous studies have suggested that as part of this complex, MALT1 functions as both a scaffolding protein to activate NF-κB through recruitment o
Externí odkaz:
https://doaj.org/article/327f71770e43439cbfdc0ac0b47f3d3d
Autor:
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Pamela A Haile, Xin Zeng, Monica N Montoute, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, John G Emery, Robert W Marquis, Peter J Gough, John Bertin
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96737 (2014)
NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a
Externí odkaz:
https://doaj.org/article/d8966b29a270430a972aa590bfa33f4f
Autor:
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Xin Zeng, Monica N Montoute, Tushar Chordia, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, Pamela A Haile, Jong Yu, John G Emery, Robert W Marquis, Peter J Gough, John Bertin
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69619 (2013)
NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the
Externí odkaz:
https://doaj.org/article/5e593a2a329d48da9774642aa0357266
Autor:
Nicholas J. Laping, Michael P. DeMartino, Joshua E. Cottom, Jeffrey M. Axten, John G. Emery, Jeffrey H. Guss, Miriam Burman, James J. Foley, Mui Cheung, Allen Oliff, Sanjay Kumar
Publikováno v:
Blood Advances, Vol 1, Iss 26, Pp 2553-2562 (2017)
Abstract: Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to potentially life-threatening infections. Granulocyte colony-stimulating factor (G-CS
Externí odkaz:
https://doaj.org/article/5aed50dd620f475cb8acf6d594f8a349
Autor:
Zhi Liu, Dai-Shi Su, Sanjay Kumar, Kimberly Roland, Lin Xiaojuan, Rick Keenan, Qin Donghui, Jeff Fergusson, Linlin Liu, John G. Emery, Sylvie Laquerre, Mui Cheung, Allen Oliff, Chengde Wu, Yan Pan, Zhiliu Zhang, Yan Chen
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report herein the discovery of quinazolindiones as potent and selective tankyrase inhibitors. Elucidation of the structure–activity relationship of the lead compound 1g led to truncated analogues that have good potency in cells
Autor:
Carsten Hopf, Anne J. Wagner, Daniel Poeckel, Christina Rau, Ray Edward Benson, Jana Krause, Gerard Drewes, John T. Moore, Elsa Salzer, John G. Emery, Douglas W. Thomson, Marcel Muelbaier, Lars Dittus, Katrin M. Mueller, Marcus Bantscheff, Birgit Duempelfeld, Lisa M. Shewchuk
Publikováno v:
Journal of Medicinal Chemistry. 60:5455-5471
The availability of high quality probes for specific protein targets is fundamental to the investigation of their function and their validation as therapeutic targets. We report the utilization of a dedicated chemoproteomic assay platform combining a
Autor:
Girieshanie Kiritharan, Megane Touzet, Eidam Hilary Schenck, John D. Harling, João Osvaldo Rodrigues Nunes, Xiao Qing Lewell, John G. Emery, Anderson Niall Andrew, Jessica Eden, Grant A. McGonagle
Publikováno v:
ACS Med Chem Lett
[Image: see text] Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) is a key mediator of innate immunity. IRAK4 overactivation is linked with several autoimmune diseases. To date, many IRAK4 inhibitors have been developed to block the protein’s ki
Autor:
James J. Foley, John G. Emery, Nicholas J. Laping, Jeffrey M. Axten, Miriam Burman, Jeffrey Guss, Demartino Michael P, Joshua E. Cottom, Sanjay Kumar, Allen Oliff, Mui Cheung
Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to potentially life-threatening infections. Granulocyte colony-stimulating factor (G-CSF) is know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9418230308829ed6c3c1b3795a98ece6
https://europepmc.org/articles/PMC5728636/
https://europepmc.org/articles/PMC5728636/
Autor:
A.J Patton, K.B. Tan, Mark E. Nuttall, John G. Emery, David J. Rieman, Jeffrey L. Mooney, Larry J. Suva, Kimberly A. Brun, Maxine Gowen, Daniel P. Nadeau, John A. Field, William P. Prichett, Heather A. McClung
Publikováno v:
Journal of Cellular Biochemistry. 76:639-650
Bipotential cells in human trabecular bone explant cultures that express osteoblast characteristics are able to undergo adipogenesis in the presence of 3-isobutyl-1-methylxanthine plus dexamethasone (Nuttall et al. [1998] J Bone Miner Res 13:371-382)
Publikováno v:
Emerging Drugs. 5:1-43
Osteoporosis is a condition which affects approximately one in four postmenopausal women and one in ten elderly men. Fractures resulting from the decrease in bone mass which characterises this dise...