Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John G, Woodland"'
Autor:
Gemma Turon, Jason Hlozek, John G. Woodland, Ankur Kumar, Kelly Chibale, Miquel Duran-Frigola
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Streamlined data-driven drug discovery remains challenging, especially in resource-limited settings. We present ZairaChem, an artificial intelligence (AI)- and machine learning (ML)-based tool for quantitative structure-activity/property rel
Externí odkaz:
https://doaj.org/article/7ee043082abc4fd8929b5a9904db622a
Publikováno v:
ACS Infectious Diseases. 9:389-393
Publikováno v:
Trends in Parasitology. 38:719-721
Inhibiting translation presents a tantalizing strategy to tackle the most virulent human malaria parasite. Xie et al. disclose a compound that binds selectively to Plasmodium falciparum tyrosine aminoacyl-tRNA synthetase, preventing the incorporation
We present ZairaChem, an artificial intelligence (AI)- and machine learning (ML)-based tool to train small-molecule activity prediction models. ZairaChem is fully automated, requires low computational resources and works across a broad spectrum of da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bf38a95b094e8bf1c809cfa0abe5eea
https://doi.org/10.1101/2022.12.13.520154
https://doi.org/10.1101/2022.12.13.520154
Autor:
Michelle F Maritz, Roslyn M Ray, Alexis J Bick, Michele Tomasicchio, John G Woodland, Yashini Govender, Chanel Avenant, Janet P Hapgood
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196043 (2018)
High usage of progestin-only injectable contraceptives, which include the intramuscular injectables depo-medroxyprogesterone acetate (DMPA-IM, Depo-Provera) and norethisterone (NET) enanthate (NET-EN or Nur-Isterate), correlates worldwide with areas
Externí odkaz:
https://doaj.org/article/f5cb8f5ff8854bd79102b1c02696166f
Publikováno v:
Nature medicine. 28(8)
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Publikováno v:
Journal of medicinal chemistry. 64(15)
Autor:
Claire, Le Manach, Jean, Dam, John G, Woodland, Gurminder, Kaur, Lutete P, Khonde, Christel, Brunschwig, Mathew, Njoroge, Kathryn J, Wicht, André, Horatscheck, Tanya, Paquet, Grant A, Boyle, Liezl, Gibhard, Dale, Taylor, Nina, Lawrence, Tomas, Yeo, Sachel, Mok, Richard T, Eastman, Dorjbal, Dorjsuren, Daniel C, Talley, Hui, Guo, Anton, Simeonov, Janette, Reader, Mariëtte, van der Watt, Erica, Erlank, Nelius, Venter, Jacek W, Zawada, Ayesha, Aswat, Luisa, Nardini, Theresa L, Coetzer, Sonja B, Lauterbach, Belinda C, Bezuidenhout, Anjo, Theron, Dalu, Mancama, Lizette L, Koekemoer, Lyn-Marie, Birkholtz, Sergio, Wittlin, Michael, Delves, Sabine, Ottilie, Elizabeth A, Winzeler, Thomas W, von Geldern, Dennis, Smith, David A, Fidock, Leslie J, Street, Gregory S, Basarab, James, Duffy, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(4)
A novel diazaspiro[3.4]octane series was identified from a