Zobrazeno 1 - 10
of 45
pro vyhledávání: '"John G, Quinn"'
Autor:
Kerry R. Buchholz, Mike Reichelt, Matthew C. Johnson, Sarah J. Robinson, Peter A. Smith, Steven T. Rutherford, John G. Quinn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Polymyxins are gram-negative antibiotics that target lipid A, the conserved membrane anchor of lipopolysaccharide in the outer membrane. Despite their clinical importance, the molecular mechanisms underpinning polymyxin activity remain unres
Externí odkaz:
https://doaj.org/article/d2780dcaa447459d8b792c67f7a80bcd
Autor:
Bruno Alicke, Eugene Varfolomeev, Shi Hui Kaylee Lee, Alexandra Frommlet, Savita Ubhayakar, John G. Quinn, Wayne J. Fairbrother, Robert Jones, Stephen E. Gould, Domagoj Vucic
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/3db51e3eb06e462e8120746067b1af78
Autor:
John G. Quinn
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract In vitro kinetic measurements allow mechanistic characterization of binding interactions and are particularly valuable throughout drug discovery, from confirmation of on-target binding in early discovery to fine-tuning of drug-binding proper
Externí odkaz:
https://doaj.org/article/ecb365e6b26849afba262a4b5282f867
Autor:
Ke Sherry Li, John G. Quinn, Matthew J. Saabye, Jesus F. Salcido Guerrero, Jim Nonomiya, Qihui Lian, Wilson Phung, Yevgeniy Izrayelit, Benjamin T. Walters, Amy Gustafson, Nicholas F. Endres, Maureen H. Beresini, Melinda M. Mulvihill
Publikováno v:
Analytical Chemistry. 94:1230-1239
Autor:
Christopher W. Davies, Angela J. Oh, Rana Mroue, Micah Steffek, John M. Bruning, Yang Xiao, Siyu Feng, Sangeeta Jayakar, Emily Chan, Vidhyalakshmi Arumugam, Sean Carlo Uribe, Jake Drummond, Alexandra Frommlet, Cheng Lu, Yvonne Franke, Mark Merchant, Hartmut Koeppen, John G. Quinn, Sushant Malhotra, Steve Do, Lewis Gazzard, Hans E. Purkey, Joachim Rudolph, Melinda M. Mulvihill, James T. Koerber, Weiru Wang, Marie Evangelista
Publikováno v:
Nature Biotechnology. 40:769-778
Small molecules that stabilize inactive protein conformations are an underutilized strategy for drugging dynamic or otherwise intractable proteins. To facilitate the discovery and characterization of such inhibitors, we created a screening platform t
Autor:
Barry Connolly, John G. Quinn
Publikováno v:
Law, Innovation and Technology. 13:377-397
There are two primary purposes of property registers. First, they make public the proprietary interests that exist in a piece of property (disclosure). Second, they provide confidence to the holder...
Autor:
Scott C. Rosenberg, Frances Shanahan, Sayumi Yamazoe, Marc Kschonsak, Yi J. Zeng, James Lee, Emile Plise, Ivana Yen, Christopher M. Rose, John G. Quinn, Lewis J. Gazzard, Benjamin T. Walters, Donald S. Kirkpatrick, Steven T. Staben, Scott A. Foster, Shiva Malek
Publikováno v:
Cell Chemical Biology. 30:175-187.e15
Autor:
Sarah G. Hymowitz, Jawahar Sudhamsu, John G. Quinn, Wilson Phung, Shiva Malek, Nicholas P. D. Liau, Avinashnarayan Venkatanarayan
Publikováno v:
Biochemistry. 59:3982-3992
The Ras-RAF-MEK-ERK signaling axis, commonly mutated in human cancers, is highly regulated to prevent aberrant signaling in healthy cells. One of the pathway modulators, 14-3-3, a constitutive dimer, induces RAF dimerization and activation by binding
Autor:
Marie Evangelista, Siyu Feng, Yang Xiao, James T. Koerber, Sushant Malhotra, Mark Merchant, Vidhyalakshmi Arumugam, Yvonne Franke, Cheng Lu, Joachim Rudolph, Christopher W. Davies, Rana Mroue, Angela Oh, Emily Chan, Sangeeta Jayakar, Melinda Mulvihil, Hans E. Purkey, John G. Quinn, Weiru Wang, Hartmut Koeppen
The discovery of covalent inhibitors binding the switch II (SWII) pocket has enabled therapeutic intervention in KRASG12C driven tumors and represents a milestone in targeting KRAS-driven cancers. However, the transient nature and high energetic barr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d446bf3d3aed775f1d51e08933a1dc
https://doi.org/10.21203/rs.3.rs-133893/v1
https://doi.org/10.21203/rs.3.rs-133893/v1
Autor:
John G. Quinn
Publikováno v:
Journal of Corporate Law Studies. 20:179-198
Crystallisation is the name given to the conversion of a floating charge into a fixed charge. While much has been written on how charges are classified as fixed or floating and on the theor...