Zobrazeno 1 - 10
of 32
pro vyhledávání: '"John G, Page"'
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 106:511-522
4-[3-(2-Nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a 2-nitroimidazole-based hypoxia-selective cytotoxin has been shown to target hypoxic regions of solid tumours. The present study is one of several pre-clinical toxico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87c3d8365a8000cdcf88027295d4fa15
https://doi.org/10.1111/j.1742-7843.2009.00532.x
https://doi.org/10.1111/j.1742-7843.2009.00532.x
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 106:497-504
In pre-clinical studies, 4-[3-(2-nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1, NSC 709257) is a weak DNA-intercalating, hypoxia-selective cytotoxin with a promising profile as an adjuvant to radio/chemotherapy and it is ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f873205e3dfa3d439f7c04645c4a5bf6
https://doi.org/10.1111/j.1742-7843.2009.00530.x
https://doi.org/10.1111/j.1742-7843.2009.00530.x
Autor:
Karen Schweikart, John G. Page, Patricia E. Noker, David H. Munn, Joel M. Reid, Sarah A. Buhrow, Joseph E. Tomaszewski, Lee Jia, Matthew M. Ames
Publikováno v:
Food and Chemical Toxicology. 46:203-211
1-methyl-d-tryptophan (D-1MT) reverses the immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO), and it is currently being developed both as a vaccine adjuvant and as an immunotherapeutic agent for combination with chemotherapy. The present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d429dda04e69dcb4b9ccc4a2adf20c
https://doi.org/10.1016/j.fct.2007.07.017
https://doi.org/10.1016/j.fct.2007.07.017
Publikováno v:
Toxicology and Applied Pharmacology. 211:115-123
Indole-3-carbinol (I-3-C) and 3,3'-diindolylmethane (DIM) have been shown to reduce the incidence and multiplicity of cancers in laboratory animal models. Based on the observation that I-3-C induced hepatocyte hypertrophy when administered orally for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54f99911ee999c91a6148513cdacbee
https://doi.org/10.1016/j.taap.2005.06.011
https://doi.org/10.1016/j.taap.2005.06.011
Autor:
Katsumi Kurokawa, Shin J. Oh, Charles D. Hébert, Yun Zhang, Karen Schweikart, John G. Page, Diogo Fraxino de Almeida
Publikováno v:
Clinical Neurophysiology. 115:1677-1682
Objective In rats the available techniques for evaluation of sensory nerve conduction are limited. We report a new method of sensory nerve conduction of the plantar nerve using needle electrodes as the recording electrodes behind the medial malleolus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee94cf41d95c9990edb71c40a99e3a7
https://doi.org/10.1016/j.clinph.2004.02.007
https://doi.org/10.1016/j.clinph.2004.02.007
Publikováno v:
The Journal of Clinical Pharmacology. 38:166-171
A 56-day pharmacokinetic study of zonisamide was conducted in 24 healthy volunteers. Steady state was achieved in 29 days including two dose escalations, and in an average of 15 days from the last dose adjustment. Twice-daily administration of 200 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd051b143649771bf1b091f17abd2c11
https://doi.org/10.1002/j.1552-4604.1998.tb04406.x
https://doi.org/10.1002/j.1552-4604.1998.tb04406.x
Autor:
Joseph E. Tomaszewski, Martin J. Murphy, Richard D. May, Blaire Osborn, Connie L. Erickson-Miller, Ralph E. Parchment, John G. Page
Publikováno v:
Cancer Chemotherapy and Pharmacology. 39:467-472
Purpose: 20(S)-Camptothecin (CAM), topotecan (TPT, active ingredient in Hycamtin) and 9-amino-20(S)-camptothecin (9AC) are topoisomerase I inhibitors that cause similar dose-limiting toxicities to rapidly renewing tissues, such as hematopoietic tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ec02d98c30efda4e8450f548ee38f9
https://doi.org/10.1007/s002800050600
https://doi.org/10.1007/s002800050600
Autor:
JAMES A. CROWELL, JOHN G. PAGE, LARRY E. RODMAN, JAMES E. HEATH, EDWIN I. GOLDENTHAL, LEROY B. HALL, GARY J. KELLOFF
Publikováno v:
Toxicological Sciences. 35:9-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22e0bc5c41046b5fae0875758d6a3aa
https://doi.org/10.1093/toxsci/35.1.9
https://doi.org/10.1093/toxsci/35.1.9
Publikováno v:
Annals of the New York Academy of Sciences. 801:205-216
Acute administration of high doses of ibogaine (IBG) to the male rat results in degeneration of Purkinje cells and reactive gliosis in the cerebellar vermis. We examined whether acute and chronic administration of IBG to male and female rats results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4cf8193df4dcfc08eb752ad359cc3e
https://doi.org/10.1111/j.1749-6632.1996.tb17443.x
https://doi.org/10.1111/j.1749-6632.1996.tb17443.x
Publikováno v:
Basicclinical pharmacologytoxicology. 106(6)
4-[3-(2-Nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a 2-nitroimidazole-based hypoxia-selective cytotoxin has been shown to target hypoxic regions of solid tumours. The present study is one of several pre-clinical toxico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::847287b06252484907a311ac78a02bef
https://pubmed.ncbi.nlm.nih.gov/20074266
https://pubmed.ncbi.nlm.nih.gov/20074266