Zobrazeno 1 - 10
of 149
pro vyhledávání: '"John G, Flannery"'
Autor:
Emilia A. Zin, Daisy Han, Jennifer Tran, Nikolas Morisson-Welch, Meike Visel, Mervi Kuronen, John G. Flannery
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 40-51 (2021)
Neuronal ceroid lipofuscinosis (NCL) is a family of neurodegenerative diseases caused by mutations to genes related to lysosomal function. One variant, CNL11, is caused by mutations to the gene encoding the protein progranulin, which regulates neuron
Externí odkaz:
https://doaj.org/article/43403be1bfe3497d97bc309d150929ca
Autor:
Bilge E Öztürk, Molly E Johnson, Michael Kleyman, Serhan Turunç, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valérie L Dufour, Simone Iwabe, Luis Felipe L Pompeo Marinho, Gustavo D Aguirre, José-Alain Sahel, David V Schaffer, Andreas R Pfenning, John G Flannery, William A Beltran, William R Stauffer, Leah C Byrne
Publikováno v:
eLife, Vol 10 (2021)
Background: Adeno-associated virus (AAV)-mediated gene therapies are rapidly advancing to the clinic, and AAV engineering has resulted in vectors with increased ability to deliver therapeutic genes. Although the choice of vector is critical, quantita
Externí odkaz:
https://doaj.org/article/2f839da7c7b643a2acc12975971ae2e2
Autor:
Michael H. Berry, Amy Holt, Autoosa Salari, Julia Veit, Meike Visel, Joshua Levitz, Krisha Aghi, Benjamin M. Gaub, Benjamin Sivyer, John G. Flannery, Ehud Y. Isacoff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Activating the spared neurons downstream of rods and cones is a potential therapeutic approach for retinal degeneration, but has been limited by the characteristics of the opsins available. Here, the authors use medium wavelength cone opsin which has
Externí odkaz:
https://doaj.org/article/73e80c971db748c985115ccc7728f498
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 165-178 (2016)
In cold-blooded vertebrates such as zebrafish, Müller glial cells (MGs) readily proliferate to replenish lost retinal neurons. In mammals, however, MGs lack regenerative capability as they do not spontaneously re-enter the cell cycle unless the reti
Externí odkaz:
https://doaj.org/article/72342b69bcca4ff58c60a6b55d45b519
Autor:
Cameron K. Baker, John G. Flannery
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The advent of optogenetics has ushered in a new era in neuroscience where spatiotemporal control of neurons is possible through light application. These tools used to study neural circuits can also be used therapeutically to restore vision. In order
Externí odkaz:
https://doaj.org/article/3a936e5c6f6245f6a84cffca6016828a
Autor:
Jennifer L. A. Tran, Nikolas Morisson-Welch, John G. Flannery, Daisy Han, Mervi Kuronen, Emilia A. Zin, Meike Visel
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss, Pp 40-51 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss, Pp 40-51 (2021)
Neuronal ceroid lipofuscinosis (NCL) is a family of neurodegenerative diseases caused by mutations to genes related to lysosomal function. One variant, CNL11, is caused by mutations to the gene encoding the protein progranulin, which regulates neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96880d0eb918ed75960fab3cd75def74
https://doi.org/10.1016/j.omtm.2021.05.009
https://doi.org/10.1016/j.omtm.2021.05.009
Autor:
Michael H. Berry, Amy Holt, Johannes Broichhagen, Prashant Donthamsetti, John G. Flannery, Ehud Y. Isacoff
Publikováno v:
Current opinion in pharmacology. 65
Blinding diseases that are caused by degeneration of rod and cone photoreceptor cells often spare the rest of the retinal circuit, from bipolar cells, which are directly innervated by photoreceptor cells, to the output ganglion cells that project axo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42b07702f0a176892f5ea43ef535507
https://pubmed.ncbi.nlm.nih.gov/35749908
https://pubmed.ncbi.nlm.nih.gov/35749908
Autor:
Amy Holt, Michael H. Berry, Jamie Lo, Prashant Donthamsetti, Meike Visel, Johannes Broichhagen, John G. Flannery, Ehud Y. Isacoff
Inherited retinal degenerations (IRDs) result in blindness due to apoptotic cell death of rods and cones, but spare other retinal neurons, providing a potential that delivery of a light-activated signaling protein to surviving neurons may restore vis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67e00bdebbc32691605daae8c58e0e8d
https://doi.org/10.1101/2022.04.07.487476
https://doi.org/10.1101/2022.04.07.487476
Autor:
Keiko, Miyadera, Evelyn, Santana, Karolina, Roszak, Sommer, Iffrig, Meike, Visel, Simone, Iwabe, Ryan F, Boyd, Joshua T, Bartoe, Yu, Sato, Alexa, Gray, Ana, Ripolles-Garcia, Valérie L, Dufour, Leah C, Byrne, John G, Flannery, William A, Beltran, Gustavo D, Aguirre
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(13)
SignificanceCanine models of inherited retinal diseases have helped advance adeno-associated virus (AAV)-based gene therapies targeting specific cells in the outer retina for treating blinding diseases in patients. However, therapeutic targeting of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70329a0b17a28c1ed0f9989922fd2e49
https://pubmed.ncbi.nlm.nih.gov/35316139
https://pubmed.ncbi.nlm.nih.gov/35316139
Autor:
Vincent Pernet, Sandrine Joly, Deniz Dalkara, Noémie Jordi, Olivia Schwarz, Franziska Christ, David V. Schaffer, John G. Flannery, Martin E. Schwab
Publikováno v:
Neurobiology of Disease, Vol 51, Iss , Pp 202-213 (2013)
The optic nerve crush injury is a well-accepted model to study the mechanisms of axonal regeneration after trauma in the CNS. The infection of retinal ganglion cells (RGCs) with an adeno-associated virus serotype 2 — ciliary neurotrophic factor (AA
Externí odkaz:
https://doaj.org/article/df4742b36aa04dd192a473fa3b283581