Zobrazeno 1 - 10
of 269
pro vyhledávání: '"John G, Flanagan"'
Autor:
Shubham Maurya, Maggie Lin, Shruthi Karnam, Tanirika Singh, Matangi Kumar, Emily Ward, Jeremy Sivak, John G. Flanagan, Karsten Gronert
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B4 produced by homeostatic astrocytes directly acts on RGCs to in
Externí odkaz:
https://doaj.org/article/09ac54ea1c9a45978669944bc8a09783
Autor:
Vincent Michael Patella, OD, Nevin W. El-Nimri, OD, PhD, John G. Flanagan, PhD, Mary K. Durbin, PhD, Timothy Bossie, OD, Derek Y. Ho, MD, PhD, Mayra Tafreshi, MBA, Michael A. Chaglasian, OD, David Kasanoff, OD, Satoshi Inoue, MSc, Sasan Moghimi, MD, Takashi Nishida, MD, PhD, Murray Fingeret, OD, Robert N. Weinreb, MD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 6, Pp 100583- (2024)
Purpose: To construct a comprehensive reference database (RDB) for a novel binocular automated perimeter. Design: A four-site prospective randomized clinical trial. Subjects and Controls: Three hundred fifty-six healthy subjects without ocular condit
Externí odkaz:
https://doaj.org/article/6aa0dbecd79e4c4b8d30453fcc0341ec
Autor:
Shruthi Karnam, Shubham Maurya, Elainna Ng, Amodini Choudhary, Arzin Thobani, John G Flanagan, Karsten Gronert
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B4 (LXB4), produced by retinal astrocytes, has direct neuroprotective actions on ret
Externí odkaz:
https://doaj.org/article/2b5f197210214fb0b04eb6ce910ffce2
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Astrocytes are a major category of glial support cell in the central nervous system and play a variety of essential roles in both health and disease. As our understanding of the diverse functions of these cells improves, the extent of hetero
Externí odkaz:
https://doaj.org/article/704abfc556014771b40c731d4b7ce760
Autor:
Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, M. Valeria Canto-Soler, John G. Flanagan, Preeti Subramanian, Sharyn Rossi, Thomas Brunner, Diane E. Bovenkamp, David J. Calkins
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss em
Externí odkaz:
https://doaj.org/article/c304792ddb214075a9d068c15e1e5d12
Autor:
Anders, Heijl, Vincent Michael, Patella, John G., Flanagan, Aiko, Iwase, Christopher K., Leung, Anja, Tuulonen, Gary C., Lee, Thomas, Callan, Boel, Bengtsson
Publikováno v:
In American Journal of Ophthalmology June 2021
Autor:
Max Koppers, Roberta Cagnetta, Toshiaki Shigeoka, Lucia CS Wunderlich, Pedro Vallejo-Ramirez, Julie Qiaojin Lin, Sixian Zhao, Maximilian AH Jakobs, Asha Dwivedy, Michael S Minett, Anaïs Bellon, Clemens F Kaminski, William A Harris, John G Flanagan, Christine E Holt
Publikováno v:
eLife, Vol 8 (2019)
Extrinsic cues trigger the local translation of specific mRNAs in growing axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly t
Externí odkaz:
https://doaj.org/article/9b3b40d5ede643c89c36904b516f8db7
Autor:
Eli M, Miloslavsky, Henrike C, Besche, Stephen B, Calderwood, Bernard S, Chang, Jules L, Dienstag, Randall W, King, Richard N, Mitchell, Richard M, Schwartzstein, Horatio, Thomas, Edward M, Hundert, John G, Flanagan
Publikováno v:
Academic Medicine. 97:1467-1473
Scientific research has been changing medical practice at an increasing pace. To keep up with this change, physicians of the future will need to be lifelong learners with the skills to engage with emerging science and translate it into clinical care.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf7003204db254cd3b4b56e77653b4a
https://doi.org/10.1097/acm.0000000000004612
https://doi.org/10.1097/acm.0000000000004612
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0189094 (2017)
Animal models of ocular hypertension are important tools for glaucoma studies. Both acute transient models and chronic models of ocular hypertension may be useful to investigate specific aspects of neurodegeneration. In this study, we compare the int
Externí odkaz:
https://doaj.org/article/f8830b29befa4146b5d4a38aef4212e0
Publikováno v:
Journal of Cellular Physiology. 237
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb3661fa7fbc80ed28c327c8ed5ce7c
https://doi.org/10.1002/jcp.30884
https://doi.org/10.1002/jcp.30884