Zobrazeno 1 - 10
of 327
pro vyhledávání: '"John Freedman"'
Autor:
June Li, Danielle Karakas, Feng Xue, Yingyu Chen, Guangheng Zhu, Yeni H. Yucel, Sonya A. MacParland, Haibo Zhang, John W. Semple, John Freedman, Qizhen Shi, Heyu Ni
Publikováno v:
Research, Vol 6 (2023)
Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of pla
Externí odkaz:
https://doaj.org/article/d855d9b595ef481e9037018204a124a5
Autor:
Xiaohong Ruby Xu, Yiming Wang, Reheman Adili, Lining Ju, Christopher M. Spring, Joseph Wuxun Jin, Hong Yang, Miguel A. D. Neves, Pingguo Chen, Yan Yang, Xi Lei, Yunfeng Chen, Reid C. Gallant, Miao Xu, Hailong Zhang, Jina Song, Peifeng Ke, Dan Zhang, Naadiya Carrim, Si-Yang Yu, Guangheng Zhu, Yi-Min She, Terry Cyr, Wenbin Fu, Guoqing Liu, Philip W. Connelly, Margaret L. Rand, Khosrow Adeli, John Freedman, Jeffrey E. Lee, Patrick Tso, Patrizia Marchese, W. Sean Davidson, Shaun P. Jackson, Cheng Zhu, Zaverio M. Ruggeri, Heyu Ni
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggr
Externí odkaz:
https://doaj.org/article/0ce3127e01234b83a479b73aff61e66c
Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
Autor:
Issaka Yougbaré, Wei-She Tai, Darko Zdravic, Brigitta Elaine Oswald, Sean Lang, Guangheng Zhu, Howard Leong-Poi, Dawei Qu, Lisa Yu, Caroline Dunk, Jianhong Zhang, John G. Sled, Stephen J. Lye, Jelena Brkić, Chun Peng, Petter Höglund, B. Anne Croy, S. Lee Adamson, Xiao-Yan Wen, Duncan J. Stewart, John Freedman, Heyu Ni
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a gestational disease caused by maternal immune responses against fetal platelets. Using a FNAIT mouse model and human trophoblast cell lines, here the authors show that uterine natural killer cel
Externí odkaz:
https://doaj.org/article/7510b05885154c00ab69cd14d56278e4
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis, Vol 25 (2019)
In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane. In this review, we pr
Externí odkaz:
https://doaj.org/article/e34d439cad974b56842b0d14368f04f4
Autor:
Andrew L. Miner, Kenneth E. Sands, Deborah S. Yokoe, John Freedman, Kristin Thompson, James M. Livingston, Richard Platt
Publikováno v:
Emerging Infectious Diseases, Vol 10, Iss 11, Pp 1931-1937 (2004)
We investigated using administrative claims data to identify surgical site infections (SSI) after breast surgery and cesarean section. Postoperative diagnosis codes, procedure codes, and pharmacy information were automatically scanned and used to ide
Externí odkaz:
https://doaj.org/article/e2e615c133d84d7982450180dcb8d264
Autor:
Valery Leytin, Asuman Mutlu, Sergiy Mykhaylov, David J. Allen, Armen V. Gyulkhandanyan, John Freedman
Publikováno v:
Haematologica, Vol 94, Iss 12 (2009)
Externí odkaz:
https://doaj.org/article/e9d5f5848f88457c905c917949c09ab9
Autor:
Jens Kjeldsen-Kragh, Michael Kim, Mette Kjær Killie, Anne Husebekk, John Freedman, John W. Semple
Publikováno v:
Haematologica, Vol 94, Iss 3 (2009)
Externí odkaz:
https://doaj.org/article/66b1bf8feeb4437b8ce9cc6ad0157656
Autor:
Hagamenon R. da Silva, Yara Aragão Costa, Luiz Carlos S. Santos, Everaldo Costa, John Freedman, Stephen Hoffman, Michael Scheld, Merle Sand, Heonir Rocha
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 79, Iss 1, Pp 29-35 (1984)
Foi avaliada a eficácia do moxalactam no tratamento de meningites em crianças, causadas por H. influenzae (27 casos) e N.meningitidis (6 casos). Dos 33 doentes tratados na dose de 100mg/Kg de peso (dose de ataque) e 50mg de 12/12 horas por via veno
Externí odkaz:
https://doaj.org/article/4b6cef5bf55c44fd9f255c490727510d
Publikováno v:
Anesthesia and analgesia. 135(3)
Our understanding of the risks associated with perioperative anemia and transfusion, in terms of increased morbidity and mortality, has evolved over the past 2 decades. By contrast, our understanding of the potential mechanisms of injury and optimal
Autor:
Aryeh, Shander, Jean-Francois, Hardy, Sherri, Ozawa, Shannon L, Farmer, Axel, Hofmann, Steven M, Frank, Daryl J, Kor, David, Faraoni, John, Freedman
Publikováno v:
Anesthesia and analgesia. 135(3)
While patient blood management (PBM) initiatives are increasingly adopted across the globe as part of standard of care, there is need for a clear and widely accepted definition of PBM. To address this, an expert group representing PBM organizations f