Zobrazeno 1 - 10
of 71
pro vyhledávání: '"John Frazer"'
Autor:
Thomas O, Schrader, Xiuwen, Zhu, Michelle, Kasem, Albert, Ren, Chunyan, Liu, Chunrui, Wu, Huong, Dang, Minh, Le, Joel, Gatlin, Kelli, Chase, John, Frazer, Kevin T, Whelan, Andrew J, Grottick, Clayton, Hutton, Jeremy, Barden, Chuan, Chen, Alvaro, Ortiz, Konrad, Feichtinger, Graeme, Semple
Publikováno v:
Bioorganicmedicinal chemistry letters. 38
A series of novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines were identified as potent and selective agonists of the 5-HT
Autor:
Lemus Asprilla, John Frazer
El tomate es uno de los ingredientes más demandados por los consumidores colombianos, este es usado en los hogares directamente en sopas, ensaladas y como condimento, pero también es materia prima para diversos procesos agroindustriales que se llev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3896::847d43743bf81b33a3ae508ab13aa5e5
https://hdl.handle.net/11634/27677
https://hdl.handle.net/11634/27677
Autor:
Xiaohua Chen, Ibragim Gaidarov, John W. Adams, John Frazer, Graeme Semple, Todd Anthony, Joel Gatlin, David J. Unett
Publikováno v:
Cellular Signalling. 50:9-24
Angiotensin (1-7) has been reported to be a ligand for the GPCR MAS1. Small molecule MAS1 modulators have also been recently characterized. Aside from convincing evidence for MAS1 activation of Gq signaling, little is known about MAS1 mediated signal
Autor:
Albert, Ren, Xiuwen, Zhu, Konrad, Feichtinger, Juerg, Lehman, Michelle, Kasem, Thomas O, Schrader, Amy, Wong, Huong, Dang, Minh, Le, John, Frazer, David J, Unett, Andrew J, Grottick, Kevin T, Whelan, Michael E, Morgan, Carleton R, Sage, Graeme, Semple
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(5)
A series of potential new 5-HT
Autor:
Clayton Hutton, Andrew J. Grottick, Graeme Semple, Konrad Feichtinger, Thomas O. Schrader, Jeremy Barden, Chunyan Liu, Kevin Whelan, Xiuwen Zhu, Chuan Chen, Chunrui Wu, John Frazer, Huong T. Dang, Joel Gatlin, Alvaro Ortiz, Minh Le, Albert S. Ren, Michelle Kasem, Kelli Chase
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 38:127872
A series of novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines were identified as potent and selective agonists of the 5-HT2C receptor. Optimizations performed on a previously reported series of racemic tetrahydroquinoline-based
Publikováno v:
Blood. 136:10-10
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer; B-lineage ALL (B-ALL) represents ~85% of cases. Transgenic humanMYC(hMYC), an oncogenic transcription factor in many blood cancers, is known to induce T-ALL in zebrafish. Until r
Autor:
Albert S. Ren, Kevin Whelan, Konrad Feichtinger, Xiuwen Zhu, Michael Morgan, David J. Unett, Graeme Semple, Andrew J. Grottick, Amy Siu-Ting Wong, Michelle Kasem, Huong T. Dang, Juerg Lehman, Minh Le, Thomas O. Schrader, John Frazer, Carleton R. Sage
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126929
A series of potential new 5-HT2 receptor scaffolds based on a simplification of the clinically studied, 5-HT2CR agonist vabicaserin, were designed. An in vivo feeding assay early in our screening process played an instrumental part in the lead identi
Publikováno v:
Palestine Exploration Quarterly. 146:254-257
Autor:
Marc Decaire, Graeme Semple, Yifeng Xiong, Andrew J. Grottick, Woo H. Yoon, Kevin Whelan, Sonja Strah-Pleynet, Martin C. Cherrier, Brett Ullman, John Frazer, Hussien A. Al-Shamma, Jin-Sun Karoline Choi, Konrad Feichtinger, Erin K. Sanabria
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1870-1873
A series of fused bicyclic heterocycles was identified as potent and selective 5-HT 2A receptor antagonists. Optimization of the series resulted in compounds that had improved PK properties, favorable CNS partitioning, good pharmacokinetic properties
Autor:
Brian M. Smith, Marissa Suarez, Douglas M. Park, Graeme Semple, Rena Hayashi, Jonathan A. Covel, Andrew J. Grottick, Jeffrey A. Schultz, Erin K. Hauser, Brian J. Hofilena, John Frazer, Vincent J. Santora, Jeff Edwards, Jason B. Ibarra, Jodie Lorea, Albert S. Ren, Scott A. Estrada, Ryan M. Hart, Jeffrey Smith, Charlemagne S. Gallardo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:71-75
The design of a new clinical candidate histamine-H(3) receptor antagonist for the potential treatment of excessive daytime sleepiness (EDS) is described. Phenethyl-R-2-methylpyrrolidine containing biphenylsulfonamide compounds were modified by replac