Zobrazeno 1 - 4
of 4
pro vyhledávání: '"John Fadul"'
Autor:
John Fadul, Teresa Zulueta-Coarasa, Gloria M. Slattum, Nadja M. Redd, Mauricio Franco Jin, Michael J. Redd, Stephan Daetwyler, Danielle Hedeen, Jan Huisken, Jody Rosenblatt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The ability to visualise stochastic invasion events is limited in murine models of metastatic cancers. Here the authors use a transparent zebrafish epidermis model to follow the invasion events of K-Ras transformed epithelial cells and show that thes
Externí odkaz:
https://doaj.org/article/61d4a58f438f4d42b3f1128793ae1242
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105330- (2022)
Summary: Metastasis is tightly linked with poor cancer prognosis, yet it is not clear how transformed cells become invasive carcinomas. We previously discovered that single KRasV12-transformed cells can invade directly from the epithelium by basal ce
Externí odkaz:
https://doaj.org/article/f7547226e5044eef84e5060ef88bcd7d
Autor:
Teresa Zulueta-Coarasa, Danielle Hedeen, Jan Huisken, Stephan Daetwyler, Jody Rosenblatt, John Fadul, Michael J. Redd, Nadja M Redd, Gloria Slattum
Metastasis is the predominant reason that patients succumb to cancer, yet the mechanisms that drive initial tumor cell invasion are poorly understood. We previously discovered that crowding-induced apical extrusion drives most epithelial cell death,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d38753ef6862012785229ff9623d3f
Autor:
Russell Bell, Laura M. Hoffman, Mary C. Beckerle, Stephen L. Lessnick, Michael E. Engel, John Fadul
Publikováno v:
Genes & Cancer
In Ewing sarcoma, NKX2-2 is a critical activated target of the oncogenic transcription factor EWS/FLI that is required for transformation. However, its biological function in this malignancy is unknown. Here we provide evidence that NKX2-2 mediates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5ab5471c89d2e6a1694c9f91cfe531
https://doi.org/10.18632/genesandcancer.57
https://doi.org/10.18632/genesandcancer.57